Plasma uric acid levels in ethanol-fed turkey poults treated with allopurinol

Czarnecki, Caroline M.; Olivero, Dennis K.; McVey, Alistair S.

doi:10.1016/0742-8413(87)90145-9

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Warmed fluids are administered orally, intravenously or intraosseously; 50-100 ml/kg is administered twice daily to diurese the patient (Echols, 2006). Allopurinol may be used to reduce uric acid production, but renal toxicity has been reported in at least one species (Czarnecki et al, 1987;Lee and Fisher, 1972). Allopurinol may be used to reduce uric acid production, but renal toxicity has been reported in at least one species (Czarnecki et al, 1987;Lee and Fisher, 1972).…”

Section: Fluid Therapymentioning

confidence: 99%

Avian anaesthesia

Longley

2008

Anaesthesia of Exotic Pets

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Section: Fluid Therapymentioning

confidence: 99%

Avian anaesthesia

Longley

2008

Anaesthesia of Exotic Pets

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“…Allopurinol is metabolised to oxypurinol by xanthine oxidase, and acts as a competitive antagonist of the enzyme that catalyses the conversion of hypoxanthine and xanthine to uric acid. It has been shown to be effective for decreasing blood uric acid levels in human beings, chimpanzees, chickens, turkeys and dogs (Weir and Fisher 1970, Czarnecki and others 1987, Smith and Wright 1987, Komoriya and others 1993, Bartges and others 1995, 1997b,) and has also been recommended for the treatment of ischaemia and leishmaniosis in dogs (Puig and others 1989, Emerit and Fabiani 1990, Liste and Gascon 1995, Kamau and others 2000, Colakoglu and others 2006, Pacher and others 2006).…”

mentioning

confidence: 99%

Effects of allopurinol on plasma uric acid levels in normouricaemic and hyperuricaemic green iguanas (Iguana iguana)

et al. 2008

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A two-phase cross-over therapeutic study was performed with 19 green iguanas (Iguana iguana) maintained within a preferred optimum temperature range of 26 to 37°C. During phase 1, they were fed a normal vegetarian diet and medicated orally with either allopurinol or a placebo control once a day for seven days. Uric acid concentrations, total protein, packed-cell volumes (PCV) and bodyweights were recorded from each lizard before and after treatment to determine the effects of allopurinol. In phase 2, after a 10-day washout period, the iguanas were fed a high protein diet to induce hyperuricaemia. Normoand hyperuricaemic iguanas that received 24·2 (3·2) mg/kg allopurinol had significantly lower mean (sd) uric acid concentrations (100·3 [53·1] µmol/l) than the controls (159·3 [100·3] µmol/l). There were no detectable interactions between the doses of allopurinol or placebo, and the iguanas' diet, weight, PCV or total protein. The allopurinol was well tolerated, and there was no significant clinical, gross or histological evidence of hepatic or renal toxicity in the iguanas that received the drug. However, in the kidneys of the hyperuricaemic iguanas that did not receive allopurinol there were proliferative changes in the glomeruli and degeneration of tubular epithelia. Allopurinol given orally at 25 mg/kg daily is able to reduce plasma uric acid levels by 41 to 45 per cent, and is therefore recommended for the treatment of hyperuricaemia in the green iguana.Veterinary Record (2008) 162, 112-115

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