Evaluation of allopurinol as a cardioprotectant in ethanol-fed turkey poults

Czarnecki, Caroline M.; McVey, Alistair S.; Olivero, Dennis K.

doi:10.1016/0742-8413(87)90146-0

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“…The present study deals with the effects of uric acid manipulation on oxidative stress, glycoxidation product, skin pentosidine (Ps) and shear value in broiler chickens. In previous studies dose rates of allopurinol from 2-50 mg/kg have been used in laboratory rats (Klein et al, 1975), 6.5 mg/kg in dogs, and varying dose rates, from 30 to 50 mg/kg, in ethanol fed turkey pullets (Czarnecki et al, 1987). In the present study the administration of allopurinol to broiler chickens was shown to decrease plasma uric acid concentrations.…”

Section: Discussionsupporting

confidence: 47%

Effect of allopurinol and hemin on some biological markers of aging in broiler chickens

Rathore¹

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Uric acid has been hypothesized as one of the most important antioxidants in limiting the accumulation of advanced glycolated endproducts in broiler breeder hens. This study was designed to quantitatively manipulate the plasma uric acid concentrations using hemin and allopurinol and determine its effect on skin pentosidine, shear force value of Pectoralis major muscle, plasma glucose, body and breast weight, and chemiluminescence induced oxidative stress in broiler chickens. Allopurinol decreased plasma uric acid, ranging from 26% to 74%, with the most pronounced effect at wk 22. Hemin increased plasma uric acid concentrations between 11 and 14%. Skin pentosidine levels increased (P<0.05) in the allopurinol fed birds, in both ad libitum and diet restricted, at 22 wk of age and in hemin fed birds at wk 22. The reduction in uric acid concentration was associated with an increase in the level of oxidative stress, which can be linked to the increase in tissue skin pentosidine, thus advancing the decline in meat tenderness.

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Section: Discussionsupporting

confidence: 47%

Effect of allopurinol and hemin on some biological markers of aging in broiler chickens

Rathore¹

View full text Add to dashboard Cite

show abstract

Evaluation of allopurinol as a cardioprotectant in ethanol-fed turkey poults

Cited by 1 publication

References 14 publications

Effect of allopurinol and hemin on some biological markers of aging in broiler chickens

Effect of allopurinol and hemin on some biological markers of aging in broiler chickens

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