Plasma uric acid levels in children.

Reduced Free-Radical-Trapping Capacity and Altered Plasma Antioxidant Status in Cystict Fibrosis

“…Plasma uric acid concentrations of 59 to 1494 pmol/L were observed; these were significantly higher than urate concentrations in controls. Normal plasma urate levels in children have previously been reported to be in the range of 60 to 440 pmol/L (36), and a similar range is reported for adults (35). The median plasma urate value for CF patients (330.8 pmol/L) was slightly above the mean value (270 pmol/L) previously observed in CF patients (37).…”

“…In the current study, all the CF patients were receiving supplements of the pancreatic enzyme preparation Creon (Reid-Rowell, Marietta, GA). Increased plasma urate levels have also been indicated in children who are below normal height and weight for their age and who suffer repeated infections (36), as is the case with CF children.…”

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

“…There are no reference ranges of values for plasma UA in children and adolescents based on large population studies. Earlier studies reported a mean of 3.6 mg/dl (range 2.0-6.7) in 204 children aged 0-13 y hospitalized for a variety of illnesses (18). In a more recent single-center study using a different assay, UA levels were found to vary with age and sex, the ranges being 2.3-6.0 mg/dl and 3.5-8.0 mg/dl for ≥13-y-old female and male participants, respectively (19).…”

“…Despite multiple investigations into the relationship between UA and HTN in children, little is known about the normal range of serum UA levels in children and adolescents. Previous studies on UA levels in children were either based on small sample size or presented only mean UA values (15)(16)(17)(18). Further, given that previous studies were not representative of the US population, it is possible that they do not broadly represent recent trends and changes in diet and demographics.…”

Inherited Deficiency of Hypoxanthine-Guanine Phosphoribosyltransferase in X-Linked Uric Aciduria (the Lesch-Nyhan Syndrome and Its Variants)

“…136 An occasional patient may have normal serum urate concentration at times. Therefore, a serum urate in the normal range does not completely rule out the Lesch-Nyhan syndrome.…”