Plasma triiodothyronine, thyroxine and thyrotrophin levels in germfree rats

Ukai, Mitsuo; Mitsuma, Terunori

doi:10.1007/bf01915370

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Plasma tetraiodothyronine (T4) and triiodothyronine (T3) concentrations were determined in duplicate using an ELISA method (Immunodiagnostics Enzymun Tests T4 and T3; Boehringer Mannheim, Meylan, France). These Enzymun kits, originally designed for use with human plasma, have been used previously (Nugon-Baudon et al 1990a, b); data obtained for rats using these kits are consistent with those reported by other authors using different methods (Ukai & Mitsuma, 1977;Jordan et al 1980;Vermorel et al 1986Vermorel et al , 1988.…”

Section: Hormone Assayssupporting

confidence: 78%

Rape-seed meal toxicity in gnotobiotic rats: influence of a whole human faecal flora or single human strains ofEscherichia coliandBacteroides vulgatus

Rabot¹,

Nugon-Baudon²,

Raibaud³

et al. 1993

Br J Nutr

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Gnotohiotic growing rats harbouring either a whole human faecal flora or single human strains of Escherichia coli (EMO) or Bactevoides vulgatus (BVSHl) were fed for 7 weeks on semi-synthetic diets in which the protein source was either soya-bean meal (SM) or rape-seed meal (RM). For each bacterial status the RM-diet group was compared with the control group fed on the S M diet. The association of human faecal flora with the R M diet was responsible for reduced feed intake and reduced weight gain, an enlargement of the liver and thyroid and a decrease in both thyroxine and triiodothyronine plasma levels. The association of the B. vufgatus BVIHl strain with the R M diet reproduced all these effects, except that triiodothyronine plasma levels were not significantly modified. Rats inoculated with the E. coli EM0 strain and fed on the R M diet exhibited a goitre and lowered thyroxine and triiodothyronine plasma levels. These results show that the human intestinal microflora may he involved in glucosinolate metabolism when cruciferous Vegetables are consumed by man. The specificity of the symptoms observed according to the rat bacterial status supports the hypothesis that bacteria yield specific toxic glucosinolate derivatives according to their enzymic potential.

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Section: Hormone Assayssupporting

confidence: 78%

Rape-seed meal toxicity in gnotobiotic rats: influence of a whole human faecal flora or single human strains ofEscherichia coliandBacteroides vulgatus

Rabot¹,

Nugon-Baudon²,

Raibaud³

et al. 1993

Br J Nutr

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“…This is the first report to study the effect of probiotics on the rate of thyroid hormones in Holstein's calves. The same results have been recorded in the blood plasma in developing germ-free rats when compared to conventional rats [10]. Raise in the rate of hepatic conversion of thyroxin into Triiodothyronine in the liver of the conventional rats and decreased from the bile salts [11].…”

Section: Resultssupporting

confidence: 55%

Effectiveness of Dietary Pediococcus on Growth and Some Vital Biochemical Parameters in Calves

El-Diasty

Zayed

Ouda

et al. 2021

Zagazig Veterinary Journal

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The oral use of Pediococcus (23×10 6 CFU/calf/day) in drinking milk once a day for one month from January till February 2020 in Holstein's calves, induced a highly significant effect on metabolic hormones, protein electrophoresis and bodyweight. Moreover, it improved the future reproductive performance of the female calves. Albumin and Gamma globulin percentages showed a significant increase in Pediococcus treated group compared to the control one. Also, there was a significant increment in insemination body weight and milk production in the treated female group compared to the control groups. On the other hand, there was a significant decrease in levels of triiodothyronine (T3) and thyroxin (T4), and alpha globulin % in groups treated by Pediococcus. Besides, there was a significant decrease in insemination age and service conception in the treated female group compared to the control female groups. Moreover, there were non-significant changes in beta globulin % in the same groups compared to the control groups. Our results concluded that the use of Pediococcus (23×10 6 CFU/calf/day) orally in drinking milk once daily for one month has highly significant effects on metabolic hormones, protein electrophoresis, body weight gain in calves; moreover, it improves the future productive and reproductive performance of the female calves.

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“…Recently, the alteration of the hormonal state of the host by intestinal microflora has been recognized (14,21,22). High endocrine response in formula-fed infants has also been reported by Lucas et al (15).…”

Section: Resultsmentioning

confidence: 90%

Relationship between the Metabolic Regulaton of Intestinal Microflora by Feeding Bifidobacterium and Host Hepatic Function

Tohyama

Tanaka

Kobayashi

et al. 1982

Bifidobacteria Microflora

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We studied the effect of feeding Bifidobacterium breve 4006 on abnormal metabolic activities in intestinal microflora and the alteration of hepatic drug-metabolizing enzyme activity in animals. Abnormal metabolic activities in intestinal microflora were induced by feeding a diet supplemented with 3% L-lysine-1% -L-tryptophan (lys-try diet) or 40% egg white protein in human flora (HF) or conventional (Cv) rats, respectively. Feeding of B. breve 4006 and transgalactosylated oligosaccharide (TOS), a growth factor of B. breve 4006, caused a significant reduction of a number of microbial enzyme activities and metabolites in the urine and the intestinal contents of HF and CV rats. Moreover , feeding of B. breve 4006 to neonate rats showed a significant decrease in the population levels of Enterobacteriaceae and Bacteroidaceae in the gut. Hepatic aniline hydroxylase (AH) and aminopyrine -N-demethylase (AMD) activities decreased significantly below normal values in HF rats fed on a lys-trp diet. In contrast, normal levels of AH and AMD activities were maintained in HF rats fed B. breve 4006 and/or TOS . The same situation was also found in overall hepatic function. The development of AH and AMD activities in neonate rats was significantly enhanced by the feeding of B . breve 4006. This enhancement seems to be due to a potent decrease of Gram-negative bacteria in the gut . In agreement with this, AH and AMD activities in gnotobiotic mice associated with Klebsiella pneumoniae and B. breve 4006 were restored to the germ-free level , whereas in mice monoassociated with K. pneumoniae, the activities significantly decreased .

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Plasma triiodothyronine, thyroxine and thyrotrophin levels in germfree rats

Abstract: Plasma T3, T4 and TSH levels in developing germfree rats were high, low and normal as compared with those in conventional counterparts. The high T3/T4 ratio in germfree rat plasma was lowered by cholestyramine feeding.

Cited by 7 publications

References 11 publications

Rape-seed meal toxicity in gnotobiotic rats: influence of a whole human faecal flora or single human strains ofEscherichia coliandBacteroides vulgatus

Rape-seed meal toxicity in gnotobiotic rats: influence of a whole human faecal flora or single human strains ofEscherichia coliandBacteroides vulgatus

Effectiveness of Dietary Pediococcus on Growth and Some Vital Biochemical Parameters in Calves

Relationship between the Metabolic Regulaton of Intestinal Microflora by Feeding Bifidobacterium and Host Hepatic Function

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