Plasma triglyceride-rich lipoprotein remnants as a risk factor of ‘Pokkuri disease’

Remnant Lipoproteins are a Stronger Risk Factor for Cardiovascular Events than LDL-C - From the Studies of Autopsies in Sudden Cardiac Death Cases

“…Based on our autopsy studies, more than two thirds of SCD cases were found to be associated with postprandial remnant hyperlipoproteinemia [11][12][13][14][15]. If severe spasm of the coronary artery is to be a crucial event prior to cardiac death in PDS, we may say that the vasospasm is not very likely to occur in coronary arteries with severe coronary artery atherosclerotic lesions due to reduced elasticity and increased stiffness or hardness of the vascular wall.…”

“…Further, Takeichi et al (11)(12)(13) suggested RLP as one of the major risk factors in SCD and PDS. Although LDL-C levels were also elevated in parallel with the majority of SCD cases who have severe coronary atherosclerosis, the role of LDL-C in fatal clinical events was not fully understood in these cases.…”

“…major risk of sudden cardiac death (10). Likewise, we previously reported a significant association between sudden cardiac death and plasma levels of RLP-C and RLP-triglyceride (RLP-TG), especially in cases of Pokkuri death (11). Pokkuri death in Japanese refers the cases who "die suddenly and unexpectedly", and had not taken any medications prior to death.…”

“…Table 1. Demography data of sudden cardiac death and control death cases with and without coronary artery atherosclerosis Both SCD with coronary atherosclerosis and PDS without coronary atherosclerosis showed abnormally high plasma RLP-C and RLP-TG level, namely postprandial remnant hyperlipoproteinemia in postmortem plasma (11)(12)(13)(14) (Table 2). RLP isolated from postmortem plasma by an immunoaffinity gel separation method (15) showed atherogenic and inflammatory effects (16,17) similar to the RLP isolated from plasma of living subjects (6).…”

Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

“…Nakajima and colleagues have reported that the majority of sudden cardiac deaths in a Japanese cohort of patients were associated with postprandial hyperlipidemia [16] and that plasma remnant lipoprotein levels were the major pathological factor involved [17]. Postprandial hyperlipidemia or raised plasma remnant lipoprotein levels have also been linked with increased carotid artery intima thickness in humans [18,19] and in a rabbit model of hereditary postprandial hypertriglyceridemia [20].…”