Plasma trehalase activity in diabetes mellitus

Eze, L. C.; Evans, David A.

doi:10.1016/0009-8981(70)90174-9

Cited by 9 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the changes mimic those of glucose, with a transient peak at 30 min and a decline at 90 min in healthy, and a steady increase over time in prediabetic and diabetic individuals, it cannot be confirmed that these changes are similarly affected by insulin and IR as known for glucose. To our knowledge, such effects on plasma trehalose have not been reported before, but an increased activity of plasma trehalase was described in diabetic states [ 53,54 ] and single nucleotide polymorphisms in the trehalase gene were recently found to be associated with type 2 diabetes. [ 55 ] Additionally, in a study on diabetic retinopathy, trehalose was detectable in most diabetic, but not in non‐diabetic participants.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Diversity of Sugar Compounds in Healthy, Prediabetic, and Diabetic Volunteers

Mack

Ferrario

Weinert

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Diabetes is thought to primarily represent a disturbance of carbohydrate metabolism; however, population studies employing metabolomics have mainly identified plasma amino acids and lipids, or their products, as biomarkers. In this pilot study, the aim is to analyze a wide spectrum of sugar compounds in the fasting state and during an oral glucose tolerance test (OGTT) in healthy, prediabetic, and type 2 diabetic volunteers. Methods and results: The three volunteer groups underwent a standard OGTT. Plasma samples obtained in the fasting state, 30 and 90 min after the OGTT, are subjected to a semitargeted GC-MS (gas chromatography-mass spectrometry) sugar profiling. Overall, 40 sugars are detected in plasma, of which some are yet unknown to change during an OGTT. Several sugars (e.g., trehalose) reveal significant differences between the volunteer groups both in fasting plasma and in distinct time courses after the OGTT. This suggests an endogenous production from orally absorbed glucose and/or an insulin-dependent production/removal from plasma. Conclusion: It is demonstrated that more sugars than expected can be found in human plasma. Since some of these show characteristic differences depending on health status, it may be worthwhile to assess their usability as biomarkers for diagnosing early-stage insulin resistance and type 2 diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the Diversity of Sugar Compounds in Healthy, Prediabetic, and Diabetic Volunteers

Mack

Ferrario

Weinert

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Other factors, however, besides duodenal trehalase activity and food trehalose content also determine the activity of plasma trehalase. Plasma trehalase activity is associated with glucose metabolism in that people with high trehalase activity are more prone to develop diabetes mellitus than people with low enzyme activity (14). In addition, especially diabetics with glycosuria have high plasma trehalase activities (15), a finding that has been interpreted as showing that trehalase has a role in renal reabsorption of glucose.…”

Section: Discussionmentioning

confidence: 99%

“…No data about the correlation between duodenal and serum trehalase are available. Serum trehalase activity is higher in diabetic than normal subjects (5).…”

mentioning

confidence: 94%

Low Trehalase Activity Is Associated with Abdominal Symptoms Caused by Edible Mushrooms

Arola

Koivula²,

Karvonen³

et al. 1999

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

It is obvious that trehalose maldigestion can cause symptoms similar to those of lactose maldigestion and intolerance. Three factors control the genesis of symptoms: 1) the activity of small-bowel trehalase: if it is low, trehalose is maldigested and more trehalose is passed into the colon; 2) the maldigested trehalose, which causes osmotic water flow into the colon, resulting in loose stools and diarrhea; and 3) most importantly, the microflora of the colon, from which symptoms will arise if there are bacteria capable of producing gases from maldigested trehalose. If colonic bacteria cannot produce gases, then distention of the abdomen and intestinal gas expulsion as eructations and flatus will not occur.

show abstract

“…In addition, the presence of trehalase in urine was recently demonstrated to be a specific index of renal tubular deficiency [33]. Furthermore, the activity of trehalase was elevated in patients with diabetes mellitus and rheumatoid arthritis [34], [35], [36], [37] and [41], [42], [43].…”

Section: Introductionmentioning

confidence: 99%

Trehalase localization in the cerebral cortex, hippocampus and cerebellum of mouse brains

Halbe

Rami

2019

Journal of Advanced Research

View full text Add to dashboard Cite

show abstract

Plasma trehalase activity in diabetes mellitus

Cited by 9 publications

References 11 publications

Exploring the Diversity of Sugar Compounds in Healthy, Prediabetic, and Diabetic Volunteers

Exploring the Diversity of Sugar Compounds in Healthy, Prediabetic, and Diabetic Volunteers

Low Trehalase Activity Is Associated with Abdominal Symptoms Caused by Edible Mushrooms

Trehalase localization in the cerebral cortex, hippocampus and cerebellum of mouse brains

Contact Info

Product

Resources

About