Plasma transfusion to prevent intraventricular haemorrhage in very preterm infants

Neary, Elaine; Áinle, Fionnuala Ní; El‐Khuffash, Afif; Cotter, Maura B.; Kirkham, Colin; McCallion, Naomi

doi:10.1002/14651858.cd012341

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…In many instances, FFP might be administered just to correct "prolonged" values in coagulation tests that might actually be developmentally appropriate. A large proportion of FFP transfusions in these infants cannot be easily justified based on risk or prior confirmed hemorrhage 5,6 To optimize FFP transfusions in neonates, we need better understanding of the developmental changes in various physiological markers of hemostasis and the interpretation of coagulation tests to detect coagulopathy. The levels of most coagulation proteins in premature infants change with gestational development , resulting in wide ranges of standard coagulation screening tests such as the prothrombin time (PT) and activated plasma thromboplastin time (APTT, Fig.…”

Section: Introductionmentioning

confidence: 99%

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Use of Fresh-frozen Plasma in Newborn Infants

Maheshwari¹,

Tyagi²,

Guaragni³

et al. 2022

Newborn

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Nearly 10% of premature and critically ill infants receive fresh-frozen plasma (FFP) transfusions to reduce their high risk of bleeding. The authors have only limited data to identify relevant clinical predictors of bleeding and to evaluate the efficacy of FFP administration. There is still no consensus on the optimal use of FFP in infants who have abnormal coagulation parameters but are not having active bleeding. The aims of this review are to present current evidence derived from clinical studies focused on the use of FFP in neonatology and then use these data to propose best practice recommendations for the safety of neonates receiving FFP.

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Section: Introductionmentioning

confidence: 99%

“…In many instances, FFP might be administered just to correct “prolonged” values in coagulation tests that might actually be developmentally appropriate. A large proportion of FFP transfusions in these infants cannot be easily justified based on risk or prior confirmed hemorrhage 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Use of Fresh-frozen Plasma in Newborn Infants

Maheshwari¹,

Tyagi²,

Guaragni³

et al. 2022

Newborn

View full text Add to dashboard Cite

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Plasma transfusion to prevent intraventricular haemorrhage in very preterm infants

Neary

Murphy

Áinle

et al. 2023

Cochrane Database of Systematic Reviews

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The impact of red blood cell transfusion in preterm neonates on germinal matrix hemorrhage: incidence and grade with correlation to outcome

Ahmed,

Saied,

Megahed

et al. 2023

Egypt Pediatric Association Gaz

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Background Germinal matrix hemorrhage affects 20 to 25% of infants with a low birth weight (less than 1500 g). About one-tenth of them progress to intra-parenchymal hemorrhage, usually during the first days after birth. Several studies have found a correlation between packed RBC transfusions and a higher frequency of severe germinal matrix hemorrhage in neonatal intensive care units. Transcranial ultrasound is a safe, noninvasive modality that can be used repeatedly in the neonates with ability to detect different grades of germinal matrix hemorrhage. Objective Was to evaluate the impact of packed RBC transfusion on the incidence and grade of germinal matrix hemorrhage, as evaluated by transcranial Doppler, and correlation to outcome. Methods This prospective observational study included one hundred preterm infants admitted to NICU, suffering from GM hemorrhage throughout 9 months duration. Bedside transcranial ultrasound was done for all the patients with a correlation of the grade of hemorrhage to the onset of blood transfusion, different clinical parameters, and the outcome. Results Statistical analysis showed a significant relation between the age of the first PRBC transfusion and GM hemorrhage grade. A positive relation was found between total amounts of PRBC transfusion and increasing grade of GM hemorrhage. A negative relation was found between GM hge grades and Apgar scores. GM hge patients who received PRBC transfusion had lower mean birth weight, lower gestational age, and longer duration of hospital stay than those who have not received PRBC transfusion. Conclusion Close monitoring of preterm neonates receiving packed RBCs, by transcranial ultrasound, as early as possible, is mandatory to early detect GM hge and limit subsequent morbidities.

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Plasma transfusion to prevent intraventricular haemorrhage in very preterm infants

Cited by 3 publications

References 35 publications

Use of Fresh-frozen Plasma in Newborn Infants

Use of Fresh-frozen Plasma in Newborn Infants

Plasma transfusion to prevent intraventricular haemorrhage in very preterm infants

The impact of red blood cell transfusion in preterm neonates on germinal matrix hemorrhage: incidence and grade with correlation to outcome

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