Plasma trace element (Se, Zn, Cu) concentrations in maternal and umbilical cord blood in Poland

Wąsowicz, Wojciech; Wołkanin, P; Bednarski, Marek; Gromadzińska, Jolanta; Skłodowska, Maria; Grzybowska, Krystyna

doi:10.1007/bf02784053

Cited by 69 publications

(32 citation statements)

References 33 publications

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“…Wasasowicz et al (1993) found no signi®cant relationship between blood zinc concentration and the number of children previously borne by a group of English mothers. However, the present study shows subjects with previous pregnancies to have serum zinc levels signi®cantly lower than those in their ®rst pregnancy (12.0 AE 1.8 mmolaL compared to 13.2 AE 2.5 mmolaL) (r 7 0.3326 between serum zinc levels and number of previous pregnancies).…”

Section: Discussionmentioning

confidence: 65%

Zinc levels in maternal milk: the influence of nutritional status with respect to zinc during the third trimester of pregnancy

et al. 1997

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Objective: To study the relationship between nutritional status with respect to zinc during the third trimester of pregnancy and levels of the same mineral in transition milk (days 13 and 14 of lactation) and mature milk (day 40 of lactation). Design: Longitudinal study. Subjects: A group of 57 healthy, lactating mothers aged between 18 and 35 y (27 AE 3.7) whose pregnancy and labour were attended by the Department of Obstetrics and Gynaecology of Cuenca INSALUD Hospital, Spain. Interventions: Zinc intake during the third trimester was determined by recording the consumption of foods over a ®ve day period and by registering zinc provided by dietary supplements. Zinc levels in maternal serum during this stage of pregnancy, and in transition and mature milk, were determined by atomic absorption spectroscopy. Results: During pregnancy all subjects showed zinc intakes lower than those recommended. Only one pregnant subject took a supplement that provided extra zinc (1 mgad). Subjects with an intake of lower than 50% of that recommended (L) (43.9%) showed signi®cantly lower serum and mature milk zinc levels than did those with higher intakes (H) (56.1%) [12.0 AE 1.5 mmolaL and 28.7 AE 6.2 mmolaL compared to 13.3 AE 2.6 mmolaL and 33.1 AE 8.0 mmolaL respectively]. 56% of L subjects and 28.6% of H subjects showed serum zinc levels of less than 12.2 mmolaL. 8% of L subjects and no H subjects showed less than 11.5 mmolaL of zinc in maternal milk. Conclusions: The diet conditions maternal serum zinc levels during pregnancy and those of milk during lactation. Though all subjects showed intakes clearly below those recommended, low levels in serum or milk were much rarer. These results support the idea that there is a need to reset the limits of normality for serum and milk zinc levels. Further work in this area may con®rm that the present recommended intakes of zinc be modi®ed. Sponsporship: This work was supported by the Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss).

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Section: Discussionmentioning

confidence: 65%

Zinc levels in maternal milk: the influence of nutritional status with respect to zinc during the third trimester of pregnancy

et al. 1997

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“…(Cousins and Hempe, 1990). Stimulus such as stress and hormones such as glucocorticoids, catecholamin, glucagon, progesterone, etc, which stimulate hepatic metallothionein synthesis (Golden, 1989;Cousins and Hempe, 1990) (Thauvin et al, 1992;Arnaud et al, 1993;Hollan and Johansen, 1993;Wasowicz et al, 1993 (Malhotra et al, 1990 (Scholl et al, 1992), Zn (Gibson, 1994) and Cu (Hall and Howell, 1969;Keen et al, 1982 (Vaquero and Navarro, 1991) and the extra Zn supply from maternal muscle catabolism due to underfeeding (Masters et al, 1986), in addition to the amounts removed from liver, bone or other organs.…”

mentioning

confidence: 99%

Relationship between moderate food restriction during pregnancy and Fe, Zn and Cu contents in maternal tissues and foetuses

Vaquero¹,

Navarro²

1996

Reprod. Nutr. Dev.

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“…Moreover, hypocupremia may result from increased transfer of Cu from mother to fetus required for the fetal development 4 . However, some investigators suggested that, low maternal plasma copper concentration is closely associated with premature rupture of membrane [19][20][21] . Again, it has been observed that incidence of preterm delivery is fewer in women, receiving micronutrient supplementation during pregnancy 13 .…”

Section: Resultsmentioning

confidence: 99%

Serum Copper and Plasma Protein Status in Preterm Delivery

Sultana

Jahan²,

Sultana³

et al. 2012

J Bangladesh Soc Physiol

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Background: Preterm delivery is a major obstetric related problem in Bangladesh. Micronutrient deficiency especially deficiency of copper may affect pregnancy, delivery and outcome of pregnancy. Reduced serum copper concentration of the pregnant mother may have some role in resulting preterm delivery. Objectives: To observe serum Cu and protein status in preterm mother and their neonates. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, between January and December 2009. A total number of 136 subjects were included in this study, and were divided into control (n=82) and study (n=54) groups. Of the control group, 28 were non pregnant women age ranged between 20-30 years, taken for reference value and another 54 were full term group, also treated as control, were sub-divided into normal full term mother (n=27) and their respective neonates ( n=27). Another 54 were preterm group, considered as study group, were sub-divided into preterm mothers (n=27) and their respective neonates (n=27). Age of preterm and full term mothers were between 20-40 years. All the subjects belonged to lower socioeconomic status. The pregnant women were selected from the labor ward of Sir Salimullah Medical College and Mitford Hospital and non pregnant women were from personal contact. Serum copper level was estimated by spectrophotometric method, to observe its level in these groups of study subjects. Serum total protein, albumin and globulin levels were estimated by usual laboratory technique in order to observe the availability of binding proteins as well as their nutritional status. Again, anthropometric data and blood hemoglobin level of the preterm and full term mother and birth weight of their respective neonates were measured to observe their nutritional status. Correlation of maternal serum copper concentration with that of neonatal blood and also with birth weight of the neonates were done to observe their relationship. Statistical analysis was done by Independent-Samples 't" test and Peaeson's correlation coefficient tests as applicable. Results: Mean serum Cu, total protein and albumin levels were significantly (p<0.001) lower in preterm mother and their neonates in comparison to those of full term mother and their neonates respectively. Whereas, mean serum globulin level showed no statistically significant difference among the groups. Mean birth weight of preterm neonates was significantly lower in comparison to that of full term neonates. Again, maternal serum copper level showed negative correlation with that of neonatal blood but positive correlation with birth weight of their neonates in both full term and preterm mother, though these relationships were not statistically significant. Conclusions: The present study revealed hypocupremia and hypoproteinemia in pre-term delivery mother and their neonates. This hypocupremia may be due to poor maternal protein status.

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Plasma trace element (Se, Zn, Cu) concentrations in maternal and umbilical cord blood in Poland

Cited by 69 publications

References 33 publications

Zinc levels in maternal milk: the influence of nutritional status with respect to zinc during the third trimester of pregnancy

Zinc levels in maternal milk: the influence of nutritional status with respect to zinc during the third trimester of pregnancy

Relationship between moderate food restriction during pregnancy and Fe, Zn and Cu contents in maternal tissues and foetuses

Serum Copper and Plasma Protein Status in Preterm Delivery

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