Plasma TGF-β<sub>1</sub>, TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity

Flisiak, Iwona; Zaniewski, Przemysław; Chodynicka, B

doi:10.1080/13547500802033300

Cited by 52 publications

(58 citation statements)

References 27 publications

(39 reference statements)

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“…Increased plasma and serum levels of IL-18 were revealed in patients with psoriasis compared to a control group [170][171][172]. An association between concentration of IL-18 and PASI index has also been reported [171,173].…”

Section: Interleukin-18 (Il-18)mentioning

confidence: 99%

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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Section: Interleukin-18 (Il-18)mentioning

confidence: 99%

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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“…Interleukin-2, Interleukin-6, Interleukin-8 and tumor necrosis factor-a (TNF-a) are the hallmark cytokines in the psoriatic cytokine network [7]. IL-1b, IL-4, IL-10, IL-17 and IL-18 too have been found to play a key role in the pathogenesis of the disease [8,9].…”

Section: Introductionmentioning

confidence: 99%

Serum Cytokine Profile in Psoriasis-A Case–Control Study in a Tertiary Care Hospital from Northern India

et al. 2011

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Psoriasis is chronic autoimmune hyperproliferative skin disease with a population prevalence of 1.5-3%. The cause of psoriasis is still not fully understood. It has been hypothesized to be an immune-mediated disorder in which the excessive reproduction of keratinocytes is due to cytokines such as interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha, secreted by infiltrating CD4(+) and CD8(+) T cells and natural killer cells. The aim of our study was to determine the serum levels of TNF-α, IL-4, IL-6 & IL-10 in psoriasis patients and compare it with healthy controls. 30 clinically diagnosed psoriasis patients and 30 age and sex matched healthy controls were included in the study. The serum cytokine levels were measured by solid phase sandwich ELISA (DIACLONE Research, France). TNF-α and IL-6 levels were significantly raised in patients and the results were statistically significant (P < 0.001). IL-4 levels were higher in patients than in controls (1.91 ± 4.7 pg/ml in cases & 0.9 ± 0.3 pg/ml in controls) but were not statistically significant. Interestingly, IL-10 levels were found to be higher in controls than in patients but again, it was not statistically significant. Pro-inflammatory cytokines play a pivotal role in the pathogenesis of psoriasis and it is the type 1(TH1) cytokine pattern, i.e., IL-6 & TNF-α, which predominate in the psoriatic T cell response. Further studies on IL-10 levels in psoriasis are recommended to establish their exact role in the pathogenesis of the disease.

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“…In contrast to the inhibitory effect of IL-6 on regulatory T-cell function [28], Th17 cell development requires IL-6 in addition to TGF-β [25]. Interestingly, increased levels of TGF-β1 and IL-6 have been found in the epidermis and the serum of psoriasis patients [28,29] and the TGF-β1 serum level correlated with disease severity [30,31], elucidating the increased level of Th17 effector cells in patients with psoriasis.…”

Section: Foxp3mentioning

confidence: 99%