Maternal serum IL-6 levels were significantly elevated in subjects with PPROM with infectious morbidity as compared to those without infectious morbidity in the present study. There was a significant rise in maternal serum IL-6 levels with increased duration of rupture of membranes and with evidence of histological chorioamnionitis and funisitis in the placenta.
Psoriasis is chronic autoimmune hyperproliferative skin disease with a population prevalence of 1.5-3%. The cause of psoriasis is still not fully understood. It has been hypothesized to be an immune-mediated disorder in which the excessive reproduction of keratinocytes is due to cytokines such as interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha, secreted by infiltrating CD4(+) and CD8(+) T cells and natural killer cells. The aim of our study was to determine the serum levels of TNF-α, IL-4, IL-6 & IL-10 in psoriasis patients and compare it with healthy controls. 30 clinically diagnosed psoriasis patients and 30 age and sex matched healthy controls were included in the study. The serum cytokine levels were measured by solid phase sandwich ELISA (DIACLONE Research, France). TNF-α and IL-6 levels were significantly raised in patients and the results were statistically significant (P < 0.001). IL-4 levels were higher in patients than in controls (1.91 ± 4.7 pg/ml in cases & 0.9 ± 0.3 pg/ml in controls) but were not statistically significant. Interestingly, IL-10 levels were found to be higher in controls than in patients but again, it was not statistically significant. Pro-inflammatory cytokines play a pivotal role in the pathogenesis of psoriasis and it is the type 1(TH1) cytokine pattern, i.e., IL-6 & TNF-α, which predominate in the psoriatic T cell response. Further studies on IL-10 levels in psoriasis are recommended to establish their exact role in the pathogenesis of the disease.
As pre-eclampsia is a disease of multifactorial aetiopathology, NO, TNF-alpha, SOD activity and NOS2A polymorphism might play an intermingled role in its development.
Introduction: Hepatitis B core (anti-HBc) antibody is an effective marker for occult Hepatitis B virus (HBV) infection and is an integral part of blood donor screening in many countries. This study was aimed to evaluate the prevalence of anti-HBc antibodies among voluntary blood donors in Thailand and its significance to reduce the risk of transfusion transmitted HBV infection. Methods: A total of 3,197 voluntary blood donor samples that were pre-screened non-reactive for HBs-Ag serology and HBV ID-NAT were tested for anti-HBc Total and IgM antibody and anti-HBs titers on ARCHITECT i6000 (Abbott Diagnostics, Illinois) between May 1, 2017 and September 31, 2017 at the National Blood Centre,
Background: Although great effort in standardization has been instituted worldwide, discrepancies among results from different immunoassay analyzers are still reported. Hence the evaluation of new assays has been advised before their implementation in the laboratory. We evaluated the assay performance of the Sysmex HISCL-5000 automated analyzer in measuring four tumor markers i.e. CEA, AFP, CA 125 and CA 19-9 and method comparison with ARCHITECT i2000SR immunoassay analyzer.
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