Plasma testosterone and serum lipids in male survivors of myocardial infarction

Poggi, U.L.; Argüelles, A.E.; Rosner, Jorge M.; Laborde, Nilsa Patritti; Cassini, J.H.; Volmer, Marcel

doi:10.1016/0022-4731(76)90206-5

Cited by 33 publications

(7 citation statements)

References 13 publications

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“…It has been demonstrated, that patients with myocardial infarction had significantly lower testosterone levels (Mendoza et al, 1983). The low testosterone levels reported here are in accord with the findings of others who have studied men with premature myocardinal infarction (Poggi et al, 1976). Elevated estradiol levels in men with acute myocardial infarction in a case-control study has also been shown (Klaiber et al, 1982).…”

Section: Discussionsupporting

confidence: 93%

Effect of padma 28 on experimental hyperlipidaemia and atherosclerosis induced by high‐fat diet in rabbits

Wójcicki

Samochowiec

Ceglecka

et al. 1988

Phytotherapy Research

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New Zealand rabbits were divided into three epual groups: (1) controls, (2) animals receiving high-fat diet (HFD) containing cholesterol and coconut oil, and (3) HFD + Padma 28. A pronounced reduction in lipid metabolism disturbancs and in severity of plaqu s formation occurred after Padma 28 had been administered. Lipid content in serum, liver homogenate and liver microsomes was depressed. An increase in the microsomal phosphatidylcholine content was ol )served. The cytochrome P-450 content in liver microsomes was significantly elevated, and the concentration of malondialdehyde in the blood serum of rabbits was decreased whilst insulin levels were normalit d and testosterone content was increased. Atherosclerotic plaque intensity at 12 weeks measured planime trically averaged 67.3% in HFD-fed animals but only 15.5% in Padma 28-treated rabbits. These findings suggest that Padma 28, in addition to lowering serum lipid level in rabbits on an experimental diet also affect metabolic processes in the liver and may modify lipid deposition in major arteries.

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Section: Discussionsupporting

confidence: 93%

Effect of padma 28 on experimental hyperlipidaemia and atherosclerosis induced by high‐fat diet in rabbits

Wójcicki

Samochowiec

Ceglecka

et al. 1988

Phytotherapy Research

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“…A large number of epidemiological and clinical studies have suggested that hyperestrogenemia predisposes to atherosclerosis in men [6, 7, 8, 9, 11, 17, 18, 19, 20]; however, there are also several studies which failed to detect alterations of sex hormone concentrations, mainly of estradiol, in CAD [2, 3, 14, 15]. Studies suggest that estradiol levels rise within 72 h of the onset of stress, but subsequently decline rapidly.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Endogenous Sex Hormone Levels, Lipoproteins and Coronary Atherosclerosis in Men Undergoing Coronary Angiography

et al. 1999

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This study was carried out in order to investigate the relationship between endogenous sex steroid hormones and coronary artery disease (CAD). Three hundred and thirty-seven men undergoing coronary angiography were enrolled in the study. Total testosterone, estradiol, free testosterone levels in men with CAD (n = 213) were compared to those of men without CAD (n = 124). No significant differences were found in the serum concentrations of estradiol, total and free testosterone and serum lipid profile between the two groups. Total and free testosterone were negatively (p < 0.05 to p < 0.001) and estradiol was positively (p < 0.05) correlated with age in both groups. Total cholesterol and low-density-lipoprotein levels were positively correlated with the level of free testosterone (r = 0.221, p < 0.01; r = 0.173, p < 0.05, respectively), and high-density-lipoprotein levels were negatively correlated with total testosterone in patients with CAD (r = –0.166, p < 0.05). The results of this study do not support the role of sex steroid hormones in CAD. However, the relationship between sex steroids and serum lipids needs further clarification.

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“…This association Several studies indicate that endogenous hormones play a role in the etiology of coronary arterỹ L-disease, either as independent risk factors or indirectly, via an effect on lipids, lipoproteins, or other heart disease risk factors. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] In general, these studies suggest that coronary artery disease is inversely related to serum androgen levels and positively related to serum estrogen levels. The existence of a causal relation between either estradiol or testosterone and coronary artery disease has not been supported by prospective investigations.17-20 A statistically significant, inverse relation between serum dehydroepiandrosterone sulfate (DHEAS) and coronary artery disease in males has, however, been documented in at least one prospective investigation .12 This retrospective, matched case-control study investigates the association between endogenous hormones, including DHEAS, and premature myocardial infarction in males.…”

mentioning

confidence: 99%

Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males.

et al. 1994

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Plasma testosterone and serum lipids in male survivors of myocardial infarction

Cited by 33 publications

References 13 publications

Effect of padma 28 on experimental hyperlipidaemia and atherosclerosis induced by high‐fat diet in rabbits

Effect of padma 28 on experimental hyperlipidaemia and atherosclerosis induced by high‐fat diet in rabbits

Relationship between Endogenous Sex Hormone Levels, Lipoproteins and Coronary Atherosclerosis in Men Undergoing Coronary Angiography

Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males.

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