Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males.

Mitchell, Laura E.; Sprecher, Dennis L.; Borecki, Ingrid B.; Rice, Treva; Laskarzewski, Peter M.; Rao, D. C.

doi:10.1161/01.cir.89.1.89

Cited by 109 publications

(53 citation statements)

References 27 publications

(18 reference statements)

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“…On the other hand, other groups did not confirm these findings using coronary angiography in two male samples (119,120). Retrospective studies have examined whether myocardial infarction survivors were characterized by reduced DHEA-S levels compared with healthy controls (115,116,118). Two of these studies demonstrated that DHEA-S levels were lower in myocardial infarction survivors compared with healthy controls (115,116), while the third one found the opposite (116).…”

Section: Cardiovascular Diseasementioning

confidence: 97%

“…Several studies have identified plasma DHEA or DHEA-S as being cardioprotective (113)(114)(115)(116)(117)(118). In both men and women, elevated DHEA-S levels were associated with retarded progression of atherosclerosis measured by coronary artery angiography (113), ultrasound carotid wall thickness (117) and pulse wave velocity aorta calcification (114).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…Retrospective studies have examined whether myocardial infarction survivors were characterized by reduced DHEA-S levels compared with healthy controls (115,116,118). Two of these studies demonstrated that DHEA-S levels were lower in myocardial infarction survivors compared with healthy controls (115,116), while the third one found the opposite (116). A study by Jansson et al (121) examined male and female myocardial infarction survivors over a 10-year follow-up period and found that although a low DHEA-S level was a predictor of cardiovascular mortality, the association was not independent of age (121).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…The reasons for the numerous discrepancies among studies are unclear at the present time. It has been suggested that they may be due to the possible confounding effect of smoking on both DHEA-S and cardiovascular disease, or to differences in the analytical methods used or to the cardiovascular endpoint selected (115,124), although some studies cited above have already avoided these caveats. It has also been hypothesized that differences may be attributable to population variability.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

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Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

Tchernof

Labrie

2004

European Journal of Endocrinology

153

100

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The age-related decline in serum dehydroepiandrosterone (DHEA) and its sulfated ester (DHEA-S) has suggested that a relative deficiency of these steroids may be causally related to the development of chronic diseases generally associated with aging, including insulin resistance, obesity, cardiovascular disease, cancer, reductions of the immune defense, depression and a general deterioration in the sensation of well-being. The numerous studies which have focused on the link between DHEA and cardiovascular disease have generally been inconsistent, generating much debate and controversy on this issue. The present article is an analysis of studies on the relationship between endogenous DHEA or DHEA-S, obesity and cardiovascular disease risk, as well as DHEA treatment studies. Elevated plasma levels of free DHEA are associated with reduced obesity in both men and women, and with smaller abdominal body fat accumulations in men. However, contradictory results have been reported regarding the relationships between the sulfate ester DHEA-S and adiposity. Age differences in the populations studied may have been a confounding factor in these associations. On the other hand, DHEA-S level is not a predictor of cardiovascular disease endpoints in women, and appears to be a relatively weak one in men. DHEA intervention studies suggest that the effects of DHEA on serum lipids are, at best, modest or non-significant. The uncertainty as to whether endogenous and exogenous DHEA should be considered cardioprotective is related to discrepancies in the literature on this topic. Several studies may have been plagued by methodological problems such as low power, unreliable analytical methods, confounding factors or other differences in the populations studied. As a consequence, the original reports demonstrating dramatic effects of either endogenous or exogenous DHEA on cardiovascular disease risk have never been replicated. We propose that the effects of DHEA on cardiovascular disease risk (either favorable or unfavorable) should be considered to be much more modest than previously believed.

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Section: Cardiovascular Diseasementioning

confidence: 97%

Section: Cardiovascular Diseasementioning

confidence: 99%

Section: Cardiovascular Diseasementioning

confidence: 99%

Section: Cardiovascular Diseasementioning

confidence: 99%

See 2 more Smart Citations

Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

Tchernof

Labrie

2004

European Journal of Endocrinology

153

100

View full text Add to dashboard Cite

show abstract

“…3±5 Male survivors of myocardial infarction have also been shown to have reduced serum DHEAS in comparison with healthy matched controls. 6,7 In women, however, a prospective study failed to ®nd any relationship between DHEAS concentrations and ischaemic heart disease (IHD). 8 Experimentally induced hyperinsulinaemia lowers DHEAS concentrations 5 and weight loss decreases plasma insulin concentrations.…”

Section: Introductionmentioning

confidence: 99%