Plasma steroids in benign prostatic hypertrophy and carcinoma of the prostate

Drafta, Demise; Proca, E; Zamfir, V; Schindler, A. E.; Neacşu, Elena; Stroe, E

doi:10.1016/0022-4731(82)90572-6

Cited by 36 publications

(11 citation statements)

References 24 publications

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“…Epidemiological studies on serum estrogens and androgens and prostate cancer risk have yielded varying results (41)(42)(43)(44)(45). The possibility that soy product intake may influence prostate cancer risk mediated by altered hormone metabolism needs to be investigated.…”

Section: Discussionmentioning

confidence: 98%

Inverse Association of Soy Product Intake With Serum Androgen and Estrogen Concentrations in Japanese Men

Nagata¹,

Inaba²,

Kawakami³

et al. 2000

Nutrition and Cancer

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The cross-sectional relationships of soy product intake and serum testosterone, estrone, estradiol, sex hormone-binding globulin, and dihydrotestosterone were examined in 69 Japanese men. Soy product intake was estimated from a semiquantitative food frequency questionnaire. Serum estradiol concentration was significantly inversely correlated with soy product intake (r = -0.32, p = 0.009), and serum estrone concentration was nonsignificantly inversely correlated with soy product intake (r = -0.24, p = 0.05) after controlling for age, body mass index, smoking status, and ethanol intake. Total and free testosterone concentrations were inversely correlated with soy product intake after controlling for the covariates, but these correlations were of border line significance (r = -0.25, p = 0.05 and r = -0.25, p = 0.06, respectively). Similar correlations were observed for these hormones with isoflavone intake from soy products. The data suggest that soy product intake may be associated with the endogenous hormone levels in Japanese men.

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Section: Discussionmentioning

confidence: 98%

Inverse Association of Soy Product Intake With Serum Androgen and Estrogen Concentrations in Japanese Men

Nagata¹,

Inaba²,

Kawakami³

et al. 2000

Nutrition and Cancer

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“…The growth and development of the prostate is under the control of testosterone and its metabolite dihydrotestosterone, and there is considerable evidence supporting a hormonal etiology for prostate cancer (Noble, 1982;Ghanadian et al, 1978;Ahluwalia et al, 1981;Drafta et al, 1982;Ross et al, 1986). Our data on hormone levels in vasectomized and non-vasectomized men provide limited support that the observed effect of vasectomy may have a hormonal basis.…”

Section: Resultsmentioning

confidence: 99%

Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men

Honda

Bernstein²,

Ross³

et al. 1988

Br J Cancer

144

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To determine whether the association with vasectomy might have a hormonal basis, we compared levels of testosterone (T) and testosterone binding globulin-binding capacity (TeBG-bc) in 33 of the vasectomized control men with levels in 33 non-vasectomized controls of the same age, weight and height. T levels were higher in vasectomized than in non-vasectomized controls (1-sided P=0.06). The ratio of T to TeBG-bc (an index of bioavailable T) was 13.5% higher in vasectomized men (1-sided P=0.03).

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“…However, more interesting would have been to instead study sexual activity during the marriage. In studies by Jackson et al [58], Zumoff et al [59]and Drafta et al [60], it was found that testosterone values were higher in males suffering from prostate cancer than controls, even though the literature varies on this point [61, 62]. It is possible that sexually active men do enjoy a different hormonal milieu, which unfortunately also may increase their risk of getting prostate cancer.…”

Section: Sexual Activitymentioning

confidence: 99%

Genetic and Environmental Factors in Prostate Cancer Genesis:Identifying High-Risk Cohorts

Ekman

1999

European Urology

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Plasma steroids in benign prostatic hypertrophy and carcinoma of the prostate

Cited by 36 publications

References 24 publications

Inverse Association of Soy Product Intake With Serum Androgen and Estrogen Concentrations in Japanese Men

Inverse Association of Soy Product Intake With Serum Androgen and Estrogen Concentrations in Japanese Men

Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men

Genetic and Environmental Factors in Prostate Cancer Genesis:Identifying High-Risk Cohorts

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