Plasma Rico en Plaquetas y su utilización en implantología dental

Garcia, VG; Corral, I.; Martínez, Antonio Bascones

doi:10.4321/s1699-65852004000200003

Cited by 4 publications

(3 citation statements)

References 13 publications

(17 reference statements)

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“…Defining the concept of repair as the restoration of a lesion by a tissue that differs from the original in morphology and function, with the existence of a greater presence of fibrous tissue ( 22 ), it was proposed that the BD/H 2 O/PRP and BD/H 2 O/PRGF groups exhibited a healed bone tissue that was a result of regeneration and not reparation. This was due to the fact that, in all the groups, the new-formed tissue was indistinguishable from the original tissue ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…Since the combination of these two platelet preparations and SIMV in drinking water has not been studied previously, it is not possible to perform an appropriate comparison with other studies. However, as the therapeutic actions of the platelet preparations have been demonstrated to be based on processes for modulation and the acceleration of scarring through the growth factors present in platelets ( 23 ), the results obtained in the BD/SIMV/PRP group may be compared with studies using PRP.…”

Section: Discussionmentioning

confidence: 99%

“…It was observed that the fracture healing in rats was dependent on the local expression of growth factors and BMPs, which act on osteoblast differentiation and promote osteogenesis. However, it has been suggested that growth factors only act to promote the proliferation and differentiation of preosteoblasts and osteoblasts, and are unlikely to act on ‘adult’ stem cells present in the bone tissue, whose differentiation is regulated by BMPs ( 23 ). Based on this, the combination of PRP with SIMV has been demonstrated to promote an increase in BMP expression, particularly BMP-2 expression, leading to increased osteoblast activity by inducing the differentiation of stem cells into osteoblast cells ( 7 , 8 ).…”

Section: Discussionmentioning

confidence: 99%

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Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone

Rivera

Monsalve

Salas

et al. 2013

Experimental and Therapeutic Medicine

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Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of treatment with either platelet-rich plasma (PRP) or plasma rich in growth factors (PRGF) in combination with SIMV in the regeneration and repair of alveolar bone. The jaws of Sprague Dawley rats (n=18) were subjected to rotary instrument-induced bone damage (BD). Animals were divided into six groups: BD/H2O (n=3), distilled water without the drug and alveolar bone damage; BD/H2O/PRP (n=3), BD and PRP; BD/H2O/PRGF (n=3), BD and PRGF; BD/SIMV (n=3), BD and water with SIMV; BD/SIMV/PRP (n=3), BD, PRP and SIMV; and BD/SIMV/PRGF (n=3), BD, PRGF and SIMV. Conventional histological analysis (hematoxylin and eosin staining) revealed that the BD/SIMV group showed indicators for mature bone tissue, while the BD/SIMV/PRP and BD/SIMV/PRGF groups showed the coexistence of indicators for mature and immature bone tissue, with no statistical differences between the platelet preparations. Simvastatin did not improve the effect of platelet-rich plasma and plasma rich in growth factors. It was not possible to determine which platelet preparation produced superior effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone

Rivera

Monsalve

Salas

et al. 2013

Experimental and Therapeutic Medicine

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Squamous Carcinoma after Dental Implants: A Clinical Case

Küstner¹,

López‐López²,

Finestres-Zubeldia³

2008

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurg

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PDGF and VEGF Levels in Platelet-Rich Plasma

González¹,

Arteaga-Vizcaíno²,

Ruiz

et al. 2013

J. Dentists

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PDGF and VEGF are two of the most potent mitogen for connective tissue, its secretion appears to be particularly important when the source is Platelet Rich Plasma (PRP), hence the latter leading role in tissue regeneration. ELISA PDGFBB levels in PRP, Platelet Poor Plasma (PPP) and exudates, were determined in 32 healthy subjects before and 24 hours after ingestion of Aspirin (ASA) and Clopidogrel (CLO). Results: PDGFBB baseline levels were 10.6 ± 1.9 ng / ml (PPP), 12.12 ± 2.5 ng / ml (PRP) and 10.84 ± 1.68 ng / ml (exudate) While after treatment with PDGFBB ASA concentrations were at 8.96 ± 1.4 ng / ml (PPP), 11.36 ± 1.48 ng / ml (PRP), 11.11 ± 1.14 ng / ml (exudate) and the Clopidogrel were 8.53 ± 0.59 ng / ml (PPP), 9.65 ± 1.17 ng / ml (PRP) and 8.51 ± 0.75 ng / ml (exudate). VEGF basal values were 973.9 ± 590.3 pg / ml (PPP), 1184.2 ± 288.4 pg / ml (PRP), 1069.3 ± 192.3 pg / ml (exudate). After treatment with ASA VEGF values were at 1439.5 ± 117.4 pg / ml (PPP), 1802.3 ± 123.9 pg / ml (PRP), 1745.6 ± 171.6 pg / ml (exudate) and the Clopidogrel were 577.8 ± 150.6 pg / ml (PPP), 668.7 ± 100.6 pg / ml (PRP), 624.9 ± 106.7 pg / ml (exudate). Conclusions: It was noted that after administration of antiplatelet drugs PDGFBB and VEGF values decreased statistically significantly, especially for the group of Clopidogrel. The ASA lesser extent appear to affect the concentrations of both factors, which may be attributable to the pharmacological action mechanism between the ASA and Clopidogrel.

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Plasma Rico en Plaquetas y su utilización en implantología dental

Abstract: Plasma Rico en Plaquetas y su utilización en implantologia dental

Cited by 4 publications

References 13 publications

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone

Squamous Carcinoma after Dental Implants: A Clinical Case

PDGF and VEGF Levels in Platelet-Rich Plasma

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