Plasma Renin Activity in Acute Renal Insufficiency

Kokot, F; Kuska, J

doi:10.1159/000179720

Cited by 78 publications

(28 citation statements)

References 10 publications

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“…First, reninangiotensin and thromboxane activity are known to be increased after ischemic injury to the kidney. Several investigators have measured increases in plasma and renal renin activity in clinical and experimental ARF (13,14,(23)(24)(25). Others have provided evidence that renal thromboxane activity is elevated after ischemia (15, 26).…”

Section: Discussionmentioning

confidence: 99%

“…The rats were returned to metabolic cages receiving water ad lib and a low-potassium diet (ICN Pharmaceuticals, Cleveland, OH) for 72 h and a standard rat chow diet (Wayne Feed, Longmont, CO) thereafter. Peak azotemia occurred between 24 and 48 h after NE infusion. Renal blood flow returned to 70% ofcontrol levels by 24 …”

Section: Methodsmentioning

confidence: 99%

“…Peak azotemia occurred between 24 and 48 h after NE infusion. Renal blood flow returned to 70% ofcontrol levels by 24 …”

Section: Methodsmentioning

confidence: 99%

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Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Robinette¹,

Conger²

1990

J. Clin. Invest.

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The roles of intrarenal angiotensin (A) and thromboxane (TX) in the vascular hypersensitivity to renal nerve stimulation (RNS) and paradoxical vasoconstriction to renal perfusion pressure (RPP) reduction in the autoregulatory range in 1 wk norepinephrine (NE)-induced acute renal failure (ARF) in rats were investigated. Renal blood flow (RBF) responses were determined before and during intrarenal infusion of an AII and TXA2 antagonist. Saralasin or SQ29548 alone partially corrected the slopes of RBF to RNS and RPP reduction in NE-ARF rats (P < 0.02). Saralasin + SQ29548 normalized the RBF response to RNS. While combined saralasin + SQ29548 eliminated the vasoconstriction to RPP reduction, similar to the effect of renal denervation, appropriate vasodilatation was not restored. Renal vein norepinephrine efflux during RNS was disproportionately increased in NE-ARF (P < 0.001) and was suppressed by saralasin + SQ29548 infusion (P < 0.005).It is concluded that the enhanced sensitivity to RNS and paradoxical vasoconstriction to RPP reduction in 1 wk NE-ARF kidneys are the result of intrarenal TX and AII acceleration of neurotransmitter release to adrenergic nerve activity. (J. Clin. Invest. 1990Invest. . 86:1532Invest. -1539

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Robinette¹,

Conger²

1990

J. Clin. Invest.

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“…It is possible that renin activation is due to prostaglandin stimulation from kinins; however, there is no direct evidence to support such a process. Angiotensin blockade may reduce the effect of the renin-angiotensin, since the latter has been shown to be stimulated by ischemia (40). However, the protective effect of angiotensin blockade would not explain the initiation of ischemia following endotoxin.…”

Section: Discussionmentioning

confidence: 99%

Glomerular dynamics and morphologic changes in the generalized Shwartzman reaction in postpartum rats.

Conger¹,

Falk²,

Guggenheim³

1981

J. Clin. Invest.

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A B S T R A C T The roles of glomerular functional and morphologic changes were examined in the acute renal failure associated with generalized Shwartzman reaction in postpartum Munich Wistar rats. The susceptibility of postpartum rats to acute deterioration in renal function after a 2-h endotoxin infusion was found to be greater than in virgin litter mates: glomerular filtration rate fell by 93% in the former vs. 24% in the latter group (P < 0.001). In postpartum rats there were marked changes in platelet count and fibrinogen level (P <0.025) compatible with consumption coagulopathy. Renal blood flow and glomerular filtration rate fell from 5.5+0.9 and 0.74+0.12 to 2.0+0.7 and 0.12±0.01 ml/min, respectively (both P < 0.001). Blood pressure did not change. Results ofglomerular dynamics studies showed decreases in single nephron filtration rate from 28±7 to 6±4 nl/min and in glomerular plasma flow rate from 77± 26 to 23± 12 nl/min (both P < 0.001). Afferent net ultrafiltration pressure fell from 20±3 to 5±4 mm Hg due to a fall in glomerular capillary hydraulic pressure from 47±1 to 29±5 mm Hg (P < 0.001). There were four-and twofold increases in afferent and efferent arteriolar resistances, respectively. Less

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“…These include: (1) 50% stenosis of the left renal artery which probably wor sened in the 3 years prior to occlusion, thereby providing a constant stimulus for development of collaterals: (2) the demonstration of significant renal blood flow by techne tium studies in the face of total renal artery occlusion, and (3) a hydrostatic pressure of 36 mm Hg in the renal artery distal to the occlusion. The extremely high periph eral vein renin could not be used in differential diagnosis, as renin can be elevated in acute tubular necrosis [13]. It is well documented that the latter can be precipitated by radiocontrast material [3], In retrospect, however, the high renin was due to the decreased hydrostatic pressure on the JGA.…”

Section: Discussionmentioning

confidence: 99%

Renal Functional Recovery 47 Days after Renal Artery Occlusion

Ramsay¹,

D’Agati²,

Dietz³

et al. 1983

Am J Nephrol

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A patient with a single kidney and oliguric renal failure for 47 days experienced dramatic restoration of glomerular filtration and renal function following graft bypass of an occluded renal artery. There was very little evidence of acute tubular necrosis. The case emphasizes the importance of the renal collateral circulation in the maintenance of tissue viability, even when the hydrostatic pressure of collateral flow is inadequate for glomerular ultrafiltrate formation. The differentiation of oliguric renal failure due to renal arterial occlusion from that due to acute tubular necrosis following arterial injection of radiocontrast material is imperative because of the dramatic response to reconstructive vascular surgery.

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Plasma Renin Activity in Acute Renal Insufficiency

Cited by 78 publications

References 10 publications

Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.

Glomerular dynamics and morphologic changes in the generalized Shwartzman reaction in postpartum rats.

Renal Functional Recovery 47 Days after Renal Artery Occlusion

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