Plasma renin activity and plasma catecholamines in intact and splenectomized running and swimming beagle dogs

Joles, Jaap A.; Hertog, J. M. Den; Huisman, G. H.; Kraan, Willem; Schaik, F. W. Van; Schrikker, A. C. M.

doi:10.1007/bf00428969

Cited by 14 publications

(12 citation statements)

References 33 publications

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“…Splenectomized dogs demonstrate a decrease of renal blood flow during free running (26), treadmill running, and swimming (16). In addition, splenectomized dogs have an enhanced release of catecholamines and of renin as compared to intact dogs (15). In intact dogs running was reported to cause a mild proteinuria (7), and in a previous study we found an increase in total protein excretion after swimming (14) but neither study differentiates between a glomerular or tubular effect.…”

Section: Introductionmentioning

confidence: 60%

Proteinuria in Intact and Splenectomized Dogs after Running and Swimming

Joles¹,

Sanders²,

Velthuizen³

et al. 1984

Int J Sports Med

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The occurrence of post-exercise proteinuria was investigated in intact and splenectomized dogs after treadmill running and swimming and compared to control experiments. Albumin and lysozyme were measured by radial diffusion. Urinary protein was analyzed by SDS-polyacrylamide gel electrophoresis. Swimming in the splenectomized dogs increased the albumin excretion in the first 30 min after exercise from 0.03 to 0.22 mg X min-1 and the lysozyme excretion in the same period from 0.11 to 0.75 micrograms X min-1. Swimming in intact dogs caused smaller increase in the lysozyme and albumin excretions during the exercise period itself as well as in the albumin excretion in the first 30 min after exercise. Running had no effect on urinary albumin or lysozyme but increased the low molecular weight protein fraction in the splenectomized dogs. Plasma lactate concentrations were higher during swimming in the splenectomized dogs than in the intact dogs. Possible mechanisms of post-exercise proteinuria are discussed.

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Section: Introductionmentioning

confidence: 60%

Proteinuria in Intact and Splenectomized Dogs after Running and Swimming

Joles¹,

Sanders²,

Velthuizen³

et al. 1984

Int J Sports Med

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“…11 Additionally, catecholamine concentrations were greater in splenectomized than in intact dogs after swimming. 18 Hypertensive hormones (eg, catecholamines, angiotensin II) are increased during exercise in people and have been proposed as factors inducing proteinuria and albuminuria. 7,16,19 Strenuous exercise in people causes a reversible increase in urinary albumin excretion of short duration.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Exercise on Urinary Albumin Excretion in Dogs

Gary¹,

Cohn²,

Kerl³

et al. 2004

J Vet Int Med

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Persistent microalbuminuria has been shown to be an indicator of glomerular damage associated with early progressive renal disease in people and dogs. In people, transient or reversible microalbuminuria has been shown to occur with exercise. A semi-quantitative test to measure microalbuminuria in the dog recently has become available. The purpose of this study was to determine if mild-to-moderate exercise induced microalbuminuria in the dog. Twenty-six dogs were included in the study after undergoing tests to rule out hyperglycemia, urinary tract infection, azotemia, and a urine protein:creatinine ratio >1. Exercise consisted of 20 minutes of flat treadmill running. Urine samples were collected on 2 separate days before exercise, the morning of exercise, 3 hours postexercise, 7-9 hours postexercise, and each of the 2 mornings after exercise. For 24 of 26 dogs, this procedure was repeated after a minimum 7-day interval between exercise sessions. The canine E.R.D. (early renal disease)-Screen Urine Test (E.R.D.-Screen test) was used to determine semiquantitative urine albumin concentrations. Microalbuminuria-positive samples, as determined by the E.R.D.-Screen test, were further analyzed to determine quantitative albumin concentrations. Four (15%) dogs were microalbuminuria positive. In each of these dogs, microalbuminuria was present both before and after exercise with no quantitative increase in urine albumin concentration postexercise. Twenty-two (85%) dogs were microalbuminuria negative throughout the study and did not develop microalbuminuria at any time after exercise. On a 95% confidence interval, the proportion of dogs that might be expected to develop microalbuminuria after exercise is between 0 and 15%.

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“…Swimming was used as the exercise modus, as running in our dogs did not consistently provoke an increased protein excretion (10). Splenectomized dogs were used as the proteinuria (10) in these dogs and other exercise responses, such as increments in plasma renin activity and plasma catecholamines (8) and renal vascular resistance (9), are more pronounced than in intact dogs.…”

Section: Methodsmentioning

confidence: 99%

“…Albuminuria in dogs occurs after swimming, in particular after splenectomy (10). Responses to swimming that possibly contribute to the occurrence of post-exercise albuminuria are acidosis (7), increased activity of the reninangiotensin system (8), and decreased renal vascular conductance (9). An increased glomerular filtration of albumm in conjunction with acidosis can be explained by a decrease of the anionic charge on the albumin molecule (4).…”

Section: Introductionmentioning

confidence: 99%

Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

Ja¹,

Nicaise²,

Sanders³

et al. 1984

Int J Sports Med

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The albuminuria occurring after swimming in splenectomized dogs was investigated. Swimming in splenectomized dogs induces metabolic acidosis, a decrease in renal vascular conductance, and an increase in plasma renin activity, all three factors possibly implicated in the occurrence of albuminuria. The administration of sodium bicarbonate prior to swimming reduced the magnitude of the acidosis and eliminated the increase in albuminuria after swimming. Phenoxybenzamine, an alpha-adrenergic blocking agent that maintains the renal blood flow during exercise also blocked the increase in albuminuria despite a decrease of blood pH during swimming. However, after metoprolol, a beta 1-adrenergic blocking agent that blocks the rise in plasma renin activity during exercise, swimming causes a threefold increase in albuminuria (P less than 0.01). The albuminuric response to swimming preceded by saline was also significant (P less than 0.05). It is likely that post-swimming albuminuria in splenectomized dogs is linked to the decrease of renal vascular conductance or to the decrease in blood pH rather than to the rise in plasma renin activity.

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Plasma renin activity and plasma catecholamines in intact and splenectomized running and swimming beagle dogs

Cited by 14 publications

References 33 publications

Proteinuria in Intact and Splenectomized Dogs after Running and Swimming

Proteinuria in Intact and Splenectomized Dogs after Running and Swimming

The Effects of Exercise on Urinary Albumin Excretion in Dogs

Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

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Plasma renin activity and plasma catecholamines in intact and splenectomized running and swimming beagle dogs

Cited by 14 publications

References 33 publications

Proteinuria in Intact and Splenectomized Dogs after Running and Swimming

Proteinuria in Intact and Splenectomized Dogs after Running and Swimming

The Effects of Exercise on Urinary Albumin Excretion in Dogs

Effects of NaHCO3, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

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Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs