Plasma protein abnormalities in nephrotic syndrome: effect on plasma colloid osmotic pressure and viscosity

Joven, Jorge; Clivillé, X; Camps, Jordi; Espinel, Eugènia; Simó, José M; Vilella, Elisabet; Oliver, A

doi:10.1093/clinchem/43.7.1223

Cited by 25 publications

(17 citation statements)

References 32 publications

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“…21 Joven J et al, had also reported similar finding of mean cholesterol 10.83±4.96, HDLc=1.43±0.32, TG= 3.98±1.12 respectively. 22 Francisco AT et al, recognize the strong inverse relationships between proteinuria and serum albumin also between serum albumin and plasma total cholesterol. Such inverse relationships with TC and TG with the serum albumin were also seen in our study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and study of lipid abnormalities in nephrotic syndrome attending a tertiary hospital, Nepal

Baral¹,

Baral

Joshi³

et al. 2018

Int J Res Med Sci

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Background: The nephrotic syndrome is a common presentation of adult or pediatric kidney diseases characterized by proteinuria, dyslipidemia, edema and hypoalbuminemia. Mainly, two types of dyslipidemia are observed: elevated serum cholesterol alone (hypercholesterolemia) and elevation of serum cholesterol along with triglyceride (combined hyperlipidemia). Therefore, majority of patients could predispose for the development of coronary artery disease and other related complications.Methods: This was the prospective hospital-based study conducted in Tribhuvan University Teaching Hospital (TUTH), Nepal. Total sixty patients who meet the inclusive criteria were selected and enrolled from Nephrology outpatient department (OPD) and ward, attending from May 2009 till August 2010.Results: In this study, total sixty patients were enrolled who was diagnosis as primary nephrotic syndrome that was established by clinical parameters supported by renal biopsy. Minimal change glomerulonephritis was common diagnosis by renal biopsy followed by Focal segmental glomerulosclerosis (FSGS). The total serum cholesterol, TG and HDL was normal in 25%, 15%, 83.3% whereas, it is high among 75%,85% and 1.7% of the study populations. Similarly, 24hour urinary protein was >3.5gm/day in all patients. Total serum protein and albumin was normal in 18.3% and 8.3% respectively whereas, rest of the patients had low serum protein and albumin levels. TC/HDLc ratios were and among them, 70% had moderate to high risk value. Similarly, in this study, the serum cholesterol, TG and TC/HDL level was inversely correlated with low protein and albumin.Conclusions: Majority of patients have derangement of lipid profile among nephrotic syndrome patients, which could also predispose for the development of coronary artery disease.

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Section: Discussionmentioning

confidence: 99%

Prevalence and study of lipid abnormalities in nephrotic syndrome attending a tertiary hospital, Nepal

Baral¹,

Baral

Joshi³

et al. 2018

Int J Res Med Sci

View full text Add to dashboard Cite

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“…Patients with nephrotic syndrome (hypoalbuminaemia, <3 g/100 ml; proteinuria, >3 g/day; and oedema formation) also exhibit hypercholesterolaemia, hyperlipidaemia and low serum albumin concentration. [70] In patients with nephrotic syndrome, the plasma concentration of α2-macroglobulin was also higher (by 197%) than that in control subjects. [70] Although hepatic CYP changes in patients with nephrotic syndrome have not been reported, NARs could serve as an animal model for the patients.…”

Section: Discussionmentioning

confidence: 95%

“…[70] In patients with nephrotic syndrome, the plasma concentration of α2-macroglobulin was also higher (by 197%) than that in control subjects. [70] Although hepatic CYP changes in patients with nephrotic syndrome have not been reported, NARs could serve as an animal model for the patients. In NARs and patients with nephrotic syndrome, effects of plasma albumin binding in circulating blood in the diuretic effect of furosemide have been reported.…”

Section: Discussionmentioning

confidence: 95%

Pharmacokinetics of drugs in mutant Nagase analbuminemic rats and responses to select diuretics

Lee

2013

Journal of Pharmacy and Pharmacology

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Objectives To report (1) the pharmacokinetics of drugs that are mainly metabolized via hepatic cytochrome P450s (CYPs) or mainly excreted via the urine and bile, (2) the mechanism for the urinary excretion of drugs (such as glomerular filtration or renal active secretion or re-absorption), and (3) the diuretic effect of some loop diuretics in mutant Nagase analbuminaemic rats (NARs), an animal model for human familial analbuminaemia based on the pharmacokinetics of drugs reported in the literatures. Key findings In NARs, the changes in the time-averaged non-renal clearances (CLNRs) of drugs that are mainly metabolized via CYPs were explained in terms of changes in the hepatic intrinsic clearance (mainly because of changes in CYPs), free (unbound) fractions of drugs in the plasma (fp) and hepatic blood-flow rate (QH) depending on the hepatic excretion ratios of drugs. Summary The CLNR changes of drugs mainly metabolized via hepatic CYPs can be sufficiently explained by the three earlier mentioned factors. The plasma albumin (furosemide) or globulin (azosemide, bumetanide and torasemide) binding affects their diuretic effects.

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“…Kaneko [22] stated that increases solely in the β-globulin fraction are not frequent and may be typical for active hepatitis. Chronic persistent liver disease, liver cirrhosis, as well as nephrotic syndrome may be associated with elevations in the β-region due to the increase of the concentrations of β 2 -microglobulin in these conditions [256]. High β-globulin concentrations may be associated also with hypercholesterolemia, which is caused by increased concentrations of β-lipoproteins in this fraction [257].…”

Section: Changes In the Globulin Fractionsmentioning

confidence: 99%

The Use of Serum Proteins in the Laboratory Diagnosis of Health Disorders in Ruminants

Tóthová¹,

Mihajlovičová²,

Nagy³

2018

Ruminants - The Husbandry, Economic and Health Aspects

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Although hundreds of proteins exist in blood serum, little is known about the precise composition and entire set of serum proteins in different ruminant species. Under physiological conditions, the production of serum proteins is closely regulated, but alterations in the serum protein pattern may occur in a wide range of diseases and health disorders. During the last several years, substantial progress was seen in the application of serum protein analyses for diagnostic purposes. The serum protein profile is mostly evaluated by serum protein electrophoresis, which allows the identification of protein fractions, each being composed of several individual proteins with similar electrophoretic mobility. Many disease processes can cause changes in the concentrations of serum proteins. Therefore, the determination of their concentrations and the evaluation of changes in their concentrations during the disease process may provide important diagnostic information for assessing the health state. Despite this usefulness, the evaluation of serum protein pattern is still relatively a less frequently used laboratory diagnostic technique in ruminant medicine. Thus, the usefulness of serum proteins in the diagnosis of health disorders and the possible clinical application of the results of the electrophoretic separation of serum proteins in ruminants will be reviewed in this chapter.

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Plasma protein abnormalities in nephrotic syndrome: effect on plasma colloid osmotic pressure and viscosity

Cited by 25 publications

References 32 publications

Prevalence and study of lipid abnormalities in nephrotic syndrome attending a tertiary hospital, Nepal

Prevalence and study of lipid abnormalities in nephrotic syndrome attending a tertiary hospital, Nepal

Pharmacokinetics of drugs in mutant Nagase analbuminemic rats and responses to select diuretics

The Use of Serum Proteins in the Laboratory Diagnosis of Health Disorders in Ruminants

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