Plasma Porphyrins in Lead Workers

Waldron, H A

doi:10.1136/oem.21.4.315

Cited by 1 publication

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“…It has been shown that the mean haemoglobin level of a group of lead workers may not differ from that of a control group despite the excretion of considerable amounts of coproporphyrin in the urine of the lead workers (Waldron, 1964), and in the present study the mean haemoglobin levels of those groups of workers in whom haemoglobin was correlated with coproporphyrin, or with ALA and PBG, were 96-1% (SD 5-4) and 959% (SD 53) respectively, that is, normal values. On the other hand, the mean coproporphyrin and ALA values were considerably raised above normal (coproporphyrinmean = 282 ,ug/l, SD 393, ALAmean = 1 46 mg/100 ml, SD 2-01) although PBG was not raised (PBGmean = 0 11 mg/100 ml, SD 0-10).…”

Section: Relationship Between Tests Indicating Intoxicationmentioning

confidence: 98%

Correlation between some parameters of lead absorption and lead intoxication

Waldron

1971

Occupational and Environmental Medicine

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Waldron, H. A. (1971).Brit. J. industr. Med.,28, 195-199. Correlation between some parameters of lead absorption and lead intoxication. Use has been made of data collected over a number of years from workers exposed to a lead hazard in a motor-car factory. The correlations between various parameters of lead absorption and lead intoxication were computed, including blood and urine lead concentrations, urinary coproporphyrin, ALA and PBG concentrations, and haemoglobin concentration. In all, 15 correlation coefficients were calculated, of which only six showed a statistically significant result (i.e., P<0·05). These six were blood lead and urine lead (r = 0·38, P<0·001), urine lead and coproporphyrin (r = 0·42, P<0·001), urine lead and ALA (r = 0·43, P<0·001), coproporphyrin and ALA (r = 0·75, P<0·001), ALA and PBG (r = 0·49, P<0·001), and urine lead and PBG (r = 0·19, P<0·05).

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Section: Relationship Between Tests Indicating Intoxicationmentioning

confidence: 98%