Correlation between some parameters of lead absorption and lead intoxication

Waldron, H A

doi:10.1136/oem.28.2.195

“…In addition, both cases had normal haemoglobin concentrations and so would have escaped detection by screening programmes based on the usual haemoglobin or blood lead criteria. Similar cases have been reported (Waldron, 1971;Gibson et al, 1968) and the latter authors recommended that lead concentrations greater than 60 ,ug/100 ml should prompt further investigation. Lead in the blood reflects absorption of the metal.…”

Section: Discussionsupporting

confidence: 68%

Lead poisoning with low blood lead levels

Torkington

¹

,

Bhalla

²

1974

Postgraduate Medical Journal

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“…In addition, both cases had normal haemoglobin concentrations and so would have escaped detection by screening programmes based on the usual haemoglobin or blood lead criteria. Similar cases have been reported (Waldron, 1971;Gibson et al, 1968) and the latter authors recommended that lead concentrations greater than 60 ,ug/100 ml should prompt further investigation.…”

supporting

confidence: 68%

Acute barbiturate poisoning in young epileptics

Hancock¹

1974

Postgraduate Medical Journal

1

0

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Summary Two young epileptic patients presenting in coma with focal neurological signs were found to be suffering from unsuspected acute barbiturate overdose. There had been strenuous denial of any possibility of psychiatric disturbance or of self-poisoning in the history obtained from their parents at the time of admission. The importance of excluding deliberate drug overdose in any young epileptic patient presenting with prolonged or atypical coma is re-emphasized.

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“…The usefulness of biochemical monitoring has been assessed by several investigators and includes the measurement of blood lead (Pb-B), urinary lead, coproporphyrin (CP), and 8-aminolevulinic acid (ALA). In particular, blood lead has been shown to be an indicator of absorption (Haeger-Aronsen, 1971;Waldron, 1971;Davies, 1972), while urinary CP and ALA are reliable indicators of effect (Gibson, Mackenzie, and Goldberg, 1968;Haeger-Aronsen, 1971). The attempts to find correlations among these biochemical parameters and other indices of effect have produced differing results ranging from significant correlation between the parameters of absorp-Requests for reprints to MHL 29 tion and effect (Cramer and Selander, 1965;Williams, King, and Walford, 1969;Wada et al, 1973) to no positive relationship (Gibson et al, 1968).…”

mentioning

confidence: 99%

Biochemical changes during the initial stages of industrial lead exposure.

Benson¹,

George²,

Litchfield³

et al. 1976

Occupational and Environmental Medicine

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. (1976). British Journal of Industrial Medicine, 33,[29][30][31][32][33][34][35]. Biochemical changes during the initial stages of industrial lead exposure. Biochemical measurements were carried out on 20 workers entering employment in a lead industry. Blood lead (Pb-B), urinary 8-aminolevulinic acid (ALA), and coproporphyrin (CP) levels were determined before entry and then at approximately weekly intervals for the first 12 weeks of employment. Levels of blood lead began to increase in all men within one week rising from an average pre-employment figure of about I 1 t,mol/l (22 ,ug/100 ml) to a value of about 2-9 ,umol/l (60 ,ug/100 ml) at three weeks. Subsequently there was only a small increase and Pb-B values levelled for the rest of the period. There was no increase in urinary ALA and CP in most subjects during the first two weeks; thereafter there was a variable pattern of excretion although three main groups of response could be discerned. Urinary ALA and CP changes related well to each other but their correlation with the characteristic increase in Pb-B fell into three categories of relationship. The major finding of the study was the very contrasting response shown by some individuals. This emphasized the need for a reasonably comprehensive biochemical screen during the early stages of employment in the lead industry in order to assess the individual biological response of a new employee to this environment. The measurement of Pb-B and urinary CP or ALA was advocated for this purpose.

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Correlation between some parameters of lead absorption and lead intoxication

Cited by 16 publications

References 16 publications

Lead poisoning with low blood lead levels

Lead poisoning with low blood lead levels

Acute barbiturate poisoning in young epileptics

Biochemical changes during the initial stages of industrial lead exposure.

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