Plasma polymerization of sulfur-rich and water-stable coatings on silica particles

Akhavan, Behnam; Jarvis, Karyn L.; Majewski, Peter

doi:10.1016/j.surfcoat.2015.01.017

Cited by 26 publications

(17 citation statements)

References 58 publications

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“…Plasma polymerization is an industry-ready process to deposit nanometer-thin coatings and has many desirable features such as substrate independence, speed, lack of solvents, and scalability. − To date, however, this technique has mainly been used for planar surfaces with little to no translation to three-dimensional (3D) particles. − Building upon this, we recently demonstrated the ability to coat polystyrene particles with a fluorinated plasma polymer . This hydrophobic overcoating led to an increase in the particle’s water contact angle.…”

Section: Introductionmentioning

confidence: 99%

“Thunderstruck”: Plasma-Polymer-Coated Porous Silicon Microparticles As a Controlled Drug Delivery System

McInnes

Michl

Delalat

et al. 2016

ACS Appl. Mater. Interfaces

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Controlling the release kinetics from a drug carrier is crucial to maintain a drug's therapeutic window. We report the use of biodegradable porous silicon microparticles (pSi MPs) loaded with the anticancer drug camphothecin, followed by a plasma polymer overcoating using a loudspeaker plasma reactor. Homogenous "Teflon-like" coatings were achieved by tumbling the particles by playing AC/DC's song "Thunderstruck". The overcoating resulted in a markedly slower release of the cytotoxic drug, and this effect correlated positively with the plasma polymer coating times, ranging from 2-fold up to more than 100-fold. Ultimately, upon characterizing and verifying pSi MP production, loading, and coating with analytical methods such as time-of-flight secondary ion mass spectrometry, scanning electron microscopy, thermal gravimetry, water contact angle measurements, and fluorescence microscopy, human neuroblastoma cells were challenged with pSi MPs in an in vitro assay, revealing a significant time delay in cell death onset.

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Section: Introductionmentioning

confidence: 99%

“Thunderstruck”: Plasma-Polymer-Coated Porous Silicon Microparticles As a Controlled Drug Delivery System

McInnes

Michl

Delalat

et al. 2016

ACS Appl. Mater. Interfaces

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“…Plasma polymers are a convenient method for coating surfaces with thin films of specific chemical functionality . These films have been used to impart functionalities such as carboxylic acids, amines, ethers, alcohols, aldehydes, thiols, and more complex structures such as α butyryl bromoesters . Such coatings allow materials to be used for a variety of applications including for biomaterials, polymer grafting and nanoparticle attachment …”

Section: Introductionmentioning

confidence: 99%

The chemistry of organophosphate thin film coatings from low pressure plasma and the effect of the substrate on adhesion

Paulino

Saboohi

Michelmore

2017

Plasma Process Polym

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Plasma polymers incorporating phosphate ions have been produced using triethyl phosphate as the precursor. Plasma phase analysis showed that the phosphate ion is highly stable in the plasma, while neutral species are more likely to be hydrocarbon precursor fragments. Increasing the RF power input increases the contribution of ions to the deposition. Surface analysis by XPS showed that the plasma polymer surfaces were a mixture of hydrocarbon species, retained PO groups, with only minor loss of PO groups. The stability of the plasma polymers in water on different substrates showed that applied RF power only had a minor effect on film solubility. The nature of the substrate − plasma species interaction is critical in being able to form insoluble structures.

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“…He did not use H 2 S plasma but performed plasma polymerization using propanethiol (CH 3 CH 2 CH 2 SH) as a precursor. Furthermore, other authors reported the formation of sulfur-rich surfaces by plasma polymerization using thiophene as a precursor [ 26 , 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of H2S Plasma Treatment on the Surface Modification of a Polyethylene Terephthalate Surface

et al. 2016

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H2S plasma created by an electrode-less radio-frequency discharge was used to modify the surface properties of the polymer polyethylene terephthalate. X-ray photoelectron spectroscopy, secondary ion mass spectrometry and atomic force microscopy were used to determine the evolution of the surface functionalities and morphology. A very thin film of chemically bonded sulfur formed on the surface within the first 10 s of treatment, whereas treatment for more than 20 s caused deposition of higher quantities of unbonded sulfur. The sulfur concentration reached a maximum of between 40 and 80 s of plasma treatment; at longer treatment times, the unbonded sulfur vanished, indicating instability of the deposited sulfur layer. Large differences in the surface morphology were observed.

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Plasma polymerization of sulfur-rich and water-stable coatings on silica particles

Cited by 26 publications

References 58 publications

“Thunderstruck”: Plasma-Polymer-Coated Porous Silicon Microparticles As a Controlled Drug Delivery System

“Thunderstruck”: Plasma-Polymer-Coated Porous Silicon Microparticles As a Controlled Drug Delivery System

The chemistry of organophosphate thin film coatings from low pressure plasma and the effect of the substrate on adhesion

Effect of H2S Plasma Treatment on the Surface Modification of a Polyethylene Terephthalate Surface

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