Plasma Pharmacokinetics and Tissue Biodistribution of Boron Following Administration of a Boronated Porphyrin in Dogs

Tibbitts, Jay; Sambol, Nancy C.; Fike, John R.; Bauer, William F.; Kahl, Stephen B.

doi:10.1002/(sici)1520-6017(200004)89:4<469::aid-jps4>3.0.co;2-6

Cited by 24 publications

(8 citation statements)

References 20 publications

(22 reference statements)

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“…Humans absorb boron primarily through inhaled air, food, and water and minimally through intact skin [ 239 , 240 ]. Physiology studies demonstrated that boron tends to reach higher levels in bone tissue (mineral portion), liver, lymph nodes, adrenals, and kidneys [ 241 , 242 ], and it is excreted mainly through urine [ 243 ].…”

Section: Discussionmentioning

confidence: 99%

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

et al. 2021

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Bone is a nutritionally modulated tissue. Given this background, aim of this review is to evaluate the latest data regarding ideal dietary approach in order to reduce bone mineral density loss and to construct a food pyramid that allows osteopenia/osteoporosis patients to easily figure out what to eat. The pyramid shows that carbohydrates should be consumed every day (3 portions of whole grains), together with fruits and vegetables (5 portions; orange-colored fruits and vegetables and green leafy vegetables are to be preferred), light yogurt (125 mL), skim milk (200 mL,) extra virgin olive oil (almost 20 mg/day), and calcium water (almost 1 l/day); weekly portions should include fish (4 portions), white meat (3 portions), legumes (2 portions), eggs (2 portions), cheeses (2 portions), and red or processed meats (once/week). At the top of the pyramid, there are two pennants: one green means that osteopenia/osteoporosis subjects need some personalized supplementation (if daily requirements cannot be satisfied through diet, calcium, vitamin D, boron, omega 3, and isoflavones supplementation could be an effective strategy with a great benefit/cost ratio), and one red means that there are some foods that are banned (salt, sugar, inorganic phosphate additives). Finally, three to four times per week of 30–40 min of aerobic and resistance exercises must be performed.

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Section: Discussionmentioning

confidence: 99%

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

et al. 2021

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“…Boronated porphyrins bearing polyhedral carboranes or borane anions have been reported by us and others to have significant potential for binary therapies such as BNCT and photodynamic therapy (PDT). [6][7][8][13][14][15] In particular, the carborane-bearing protoporphyrin derivative BOPP has been shown to have strong tumor localizing and retention properties in other solid tumors, and a significantly different pharmacokinetic and pharmacodynamic profile from BPA. In mice with intracerebrally implanted brain tumors, ip or iv treatment with BOPP produced maximal tumor boron uptake at ∼24 h with very high selectivity for tumor over normal brain (up to 400:1) and good tumor/blood ratios.…”

Section: Discussionmentioning

confidence: 99%

“…8 In the biodistribution studies of BOPP performed in a variety of small and large animals, a high concentration of boron was always found in the liver. [6][7][8] It was proposed that this organ might accumulate the compound at early times, acting as a reservoir, and releasing it or a metabolite into the circulation at later times (5-7 days). This proposition is at least consistent with our present results.…”

Section: Discussionmentioning

confidence: 99%

Biodistribution of Boron Compounds in an Animal Model of Human Undifferentiated Thyroid Cancer for Boron Neutron Capture Therapy

et al. 2005

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Undifferentiated thyroid carcinoma (UTC) is a rapidly growing, highly invasive malignant tumor that currently lacks any effective treatment. Boron neutron capture therapy (BNCT) has been investigated recently for some types of tumors including glioblastoma multiforme and malignant melanoma. In previous studies we have shown the selective uptake of p-boronophenylalanine (BPA) by undifferentiated thyroid cancer cells in vitro and in vivo, as well as the histologic cure of 50% of the nude mice transplanted with human UTC cells when treated with BPA and an appropriate neutron beam. The present studies were performed to further optimize this treatment through the investigation of a boronated porphyrin, both alone and in combination with BPA. In vitro studies with cells in culture showed that BOPP (tetrakis-carborane carboxylate ester of 2,4-bis-(alpha,beta-dihydroxyethyl)-deutero-porphyrin IX) is localized intracellularly, with a highest concentration in the 11500g (mitochondrial-enriched pellet) fraction. When BOPP was administered alone to NIH nude mice transplanted with UTC human cells, no significant tumor uptake or selectivity in our in vivo model was observed. In contrast, when BOPP was injected 5-7 days before BPA and the animals were sacrificed 60 min after administration of BPA, a significant increase in boron uptake by the tumor was found (38-45 ppm with both compounds vs 20 ppm with BPA alone). On day 5 the tissue boron selectivity ratios were tumor/blood approximately 3.8 and tumor/distal skin approximately 1.8. Other important ratios were tumor/thyroid approximately 6.6 and tumor/lung approximately 2.9. These results open the possibility of improving the efficacy of BNCT for the treatment of this so far "orphan" tumor.

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“…23 Um dos destaques de aplicação destes compostos tem sido no tratamento de tumores intracranianos, onde a necessidade de precisão para tratamentos é muito elevada. 24 As BOPPs apresentam boa viabilidade sintética e são facilmente purificadas, apresentam baixa toxicidade e alta seletividade tumoral, acumulando-se preferencialmente nas mitocôndrias das células cancerígenas. [20][21][22][23][24] Outra abordagem para tratamentos por PDT que vem se destacando é a produção de protoporfirina IX promovida pelas próprias células.…”

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“…24 As BOPPs apresentam boa viabilidade sintética e são facilmente purificadas, apresentam baixa toxicidade e alta seletividade tumoral, acumulando-se preferencialmente nas mitocôndrias das células cancerígenas. [20][21][22][23][24] Outra abordagem para tratamentos por PDT que vem se destacando é a produção de protoporfirina IX promovida pelas próprias células. Fundamentalmente, quando se administra o cloridrato do ácido 5aminolevuliníco (5-ALA -Levulan ® , DUSA Pharmaceuticals, Inc.) de forma tópica, após algumas horas é observado um acúmulo de protoporfirina IX, sendo possível a irradiação local com luz (630 nmluz vermelha) e efetuar os tratamentos por PDT.…”

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Basic Concepts and Applications of Porphyrins, Chlorins and Phthalocyanines as Photosensitizers in Photonic Therapies

Oliveira¹,

Souza²,

Gobo³

et al. 2015

Revista Virtual De Química

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This review describes applications of light in photonic therapies, especially photodynamic therapy (PDT) which involves the combination of light, photosensitizer and oxygen. Relevant examples of porphyrins, chlorins and phthalocyanines were chosen and are presented, among the commercially available and presently under study photosensitizers of interest at the moment. Our objective is not to be exhaustive, but discuss the general ideas on PDT and photosensitizers as they demonstrate interaction with light and the human body.

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Plasma Pharmacokinetics and Tissue Biodistribution of Boron Following Administration of a Boronated Porphyrin in Dogs

Cited by 24 publications

References 20 publications

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

Biodistribution of Boron Compounds in an Animal Model of Human Undifferentiated Thyroid Cancer for Boron Neutron Capture Therapy

Basic Concepts and Applications of Porphyrins, Chlorins and Phthalocyanines as Photosensitizers in Photonic Therapies

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