Plasma parathyroid hormone and divalent cation response to induction of acute metabolic acidosis

Oster, James R.; Pérez, Guido O.; Canterbury, Janet M.; Alpert, Helen; Vaamonde, Carlos A.

doi:10.1139/y82-222

Cited by 7 publications

(9 citation statements)

References 2 publications

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“…We showed that the acute induction of both Met Acid and Resp Acid stimulated PTH secretion. Although our results in acute Met Acid are similar to those in previous studies, those studies did not control for acidosis‐induced changes in the plasma calcium concentration (1,2,5) . In a study that reversed the sequence and corrected Met Acid while controlling for changes in ionized calcium, the rapid correction of Met Acid reduced PTH values (31) .…”

Section: Discussionsupporting

confidence: 73%

“…A confounding factor is that these studies did not control for acidosis‐induced increases in the ionized calcium concentration. In previous studies of acute Met Acid and Resp Acid, it has been reported that (1) Met Acid increases PTH levels although ionized calcium values increase (2,5) and (2) Resp Acid does not affect PTH levels. But this latter observation was in a setting in which the effect of an increased ionized calcium value was not determined (6) …”

Section: Introductionmentioning

confidence: 94%

“…D espite considerable effort during the past several decades, it has been difficult to establish with certainty whether acidosis directly affects parathyroid hormone (PTH) secretion. The major problem has been that both metabolic acidosis (Met Acid) and respiratory acidosis (Resp Acid) have diverse effects on mineral metabolism, which among others include changes in serum calcium and phosphate values, (1–7) urinary excretion of calcium and phosphate, (1,6–11) calcitriol metabolism, (7,12–15) the renal and skeletal response to PTH, (16–18) urinary buffering of acid, (11) and the flux of calcium to and from bone (19,20) . These confounding factors have made it difficult to separate whether Met Acid and Resp Acid have direct or indirect effects on PTH secretion.…”

Section: Introductionmentioning

confidence: 99%

“…It would seem that to evaluate a direct effect of acidosis on PTH secretion, it is better to study PTH secretion during acute acidosis before compensatory mechanisms predominate. But only limited information is available on how the acute induction of Met Acid and Resp Acid affects PTH secretion (2,5,6) . A confounding factor is that these studies did not control for acidosis‐induced increases in the ionized calcium concentration.…”

Section: Introductionmentioning

confidence: 99%

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Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

López

Aguilera–Tejero

Felsenfeld

et al. 2002

J of Bone & Mineral Res

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Because both metabolic (Met Acid) and respiratory acidosis (Resp Acid) have diverse effects on mineral metabolism, it has been difficult to establish whether acidosis directly affects parathyroid hormone (PTH) secretion. Our goal was to determine whether acute Met Acid and Resp Acid directly affected PTH secretion. Three groups of dogs were studied: control, acute Met Acid induced by HCl infusion, and acute Resp Acid induced by hypoventilation. EDTA was infused to prevent acidosis-induced increases in ionized calcium, but more EDTA was needed in Met Acid than in Resp Acid. The PTH response to EDTA-induced hypocalcemia was evaluated also. Magnesium needed to be infused in groups receiving EDTA to prevent hypomagnesemia. The half-life of intact PTH (iPTH) was determined during hypocalcemia when PTH was measured after parathyroidectomy. During normocalcemia, PTH values were greater (p < 0.05) in Met Acid (92 ؎ 19 pg/ml) and Resp Acid (77 ؎ 22 pg/ml) than in controls (27 ؎ 5 pg/ml); the respective pH values were 7.23 ؎ 0.01, 7.24 ؎ 0.01, and 7.39 ؎ 0.02. The maximal PTH response to hypocalcemia was greater (p < 0.05) in Met Acid (443 ؎ 54 pg/ml) than in Resp Acid (267 ؎ 37 pg/ml) and controls (262 ؎ 48 pg/ml). The half-life of PTH was greater (p < 0.05) in Met Acid than in controls, but the PTH secretion rate also was greater (p < 0.05) in Met Acid than in the other two groups. In conclusion, (

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

López

Aguilera–Tejero

Felsenfeld

et al. 2002

J of Bone & Mineral Res

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“…Acidosis can also increase serum PTH concentration, but results are quite conflicting (Oster et al 1982).…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone concentrations during and after two periods of high intensity exercise with and without an intervening recovery period

et al. 2003

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The purpose of this study was to examine the effect of a recovery period between two periods of exercise on bone metabolism and related hormones. Concentrations of serum parathyroid hormone ([PTH]), plasma ionized calcium ([Ca(2+)]) and total calcium were measured. A group of 12 healthy men aged 20-27 years participated in this study. They took part in two exercise protocols (P(1) and P(2)) on two separate weeks. The exercise in P(1) comprised two successive periods of 21 min each at 70% and 85% of maximal oxygen uptake; P(2) comprised two periods of exercise at the same intensities but separated by 40 min of recovery. Venous blood samples were collected 1 day before the sessions (control), before each protocol, during (7th and 21st min), at the end (42nd min in P(1) and 82nd min in P(2)) and after 24 h of recovery. The [PTH] was significantly elevated during the two protocols ( P<0.01), remained raised in P(1) after 24 h of recovery ( P<0.05) and was significantly lower ( P<0.01) at the end of P(2) when compared to P(1). The [Ca(2+)] decreased significantly during and at the end of the two protocols ( P<0.01) and had returned to control values after 24 h of recovery. Plasma lactate concentration increased during the two protocols ( P<0.01) and returned to control values after recovery. These results indicate firstly that [Ca(2+)] decreases during continuous exercise as [PTH] increases and remains raised after 24 h of recovery, secondly that a recovery period between two periods of exercise attenuates the variations in [Ca(2+)] and [PTH], and thirdly that recovery may have anabolic effects on bone. However, the small physiological changes observed prevent us from forming any firm conclusion about this.

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Effect of acute reversal of experimentally-induced ketoacidosis with sodium bicarbonate on the plasma concentrations of phosphorus and potassium

et al. 1988

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Plasma parathyroid hormone and divalent cation response to induction of acute metabolic acidosis

Cited by 7 publications

References 2 publications

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

Parathyroid hormone concentrations during and after two periods of high intensity exercise with and without an intervening recovery period

Effect of acute reversal of experimentally-induced ketoacidosis with sodium bicarbonate on the plasma concentrations of phosphorus and potassium

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