Plasma oxylipin levels associated with preterm birth in preterm labor✰

Svenvik, Maria; Raffetseder, Johanna; Brudin, Lars; Lindberg, Richard H.; Blomberg, Marie; Axelsson, Daniel; Jenmalm, Maria C.; Ernerudh, Jan; Nording, Malin L.

doi:10.1016/j.plefa.2021.102251

Cited by 6 publications

(2 citation statements)

References 29 publications

(43 reference statements)

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“…A proper reference interval may also restrict unnecessary interventions, such as unnecessary frequent maternal controls, prolonged antenatal hospital care or immobilization. A distinct reference interval could discriminate pathological pregnancies where inflammation already is a known important risk factor in an earlier stage than currently used such as preterm onset of labor or premature preterm rupture of membranes ( 43 ). It could also facilitate clinical decisions for managing complicated pregnancies such as preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

et al. 2021

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Although several biomarkers are available to monitor the acute phase response, the short pentraxin C-reactive protein (CRP) is dominating in clinical practice. The long pentraxin 3 (PTX3) is structurally and functionally related to CRP, but not liver-derived. In addition, increased levels of PTX3 have been linked to preeclampsia. Reference intervals are usually based on healthy blood donors. Several physiological and immunological alterations occur during normal pregnancy with subsequent potential effects on blood analytes. Hence, this study aims to determine pregnancy-specific reference intervals for CRP and PTX3. Longitudinal clinical data and blood plasma samples from the 1st, 2nd and 3rd trimester of 100 healthy, non-medicating, females aged 18–40 at the time-point of conception were available to us. High‐sensitivity CRP measurements were performed by turbidimetry and enzyme-linked immunosorbent assay (ELISA) was used to quantify PTX3. CRP and PTX3 levels followed each other during the first two trimesters and both increased during the third trimester. CRP showed a median of 4.12 mg/L in the third trimester, and were significantly higher compared to the first (median 2.39 mg/L, p<0.0001) and the second (median 2.44 mg/L, p=0.0006) trimesters. In the third trimester PTX3 levels reached a median of 7.70 µg/L, and were significantly higher compared to the first (median 3.33 µg/L, p<0.0001) and the second (median 3.70 µg/L, p<0.0001) trimesters. Plasma albumin was inversely correlated with CRP (rho=-0.27, p<0.0001), but not with PTX3. In conclusion, it is important to consider pregnancy-specific reference values as elevations of CRP and PTX3 during the later phase may occur in absence of infection.

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Section: Discussionmentioning

confidence: 99%

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

et al. 2021

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“…Several of these oxylipins have been associated with pregnancy and gestation. 9,10-and 15,16-DiHODE have been found at higher concentrations in the corpus lutea in pregnant cattle [158], and lower levels of 9,10-DiHODE have been associated with an increase in preterm delivery prior to 34 weeks [159], but the implications of this have not been determined.…”

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confidence: 99%

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids

Eccles

Baldwin

2022

Cells

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This manuscript reviews the CYP-mediated production of oxylipins and the current known function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families 1–3. Our knowledge of oxylipin function has greatly increased over the past 3–7 years with new theories on stability and function. This includes a significant amount of new information on oxylipins produced from linoleic acid (LA) and the omega-3 PUFA-derived oxylipins such as α-linolenic acid (ALA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). However, there is still a lack of knowledge regarding the primary CYP responsible for producing specific oxylipins, and a lack of mechanistic insight for some clinical associations between outcomes and oxylipin levels. In addition, the role of CYPs in the production of oxylipins as signaling molecules for obesity, energy utilization, and development have increased greatly with potential interactions between diet, endocrinology, and pharmacology/toxicology due to nuclear receptor mediated CYP induction, CYP inhibition, and receptor interactions/crosstalk. The potential for diet-diet and diet-drug/chemical interactions is high given that these promiscuous CYPs metabolize a plethora of different endogenous and exogenous chemicals.

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Bioactive metabolites of OMEGA-6 and OMEGA-3 fatty acids are associated with inflammatory cytokine concentrations in maternal and infant plasma at the time of delivery

Slotkowski,

VanOrmer,

Akbar

et al. 2024

Clinical Nutrition ESPEN

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Plasma oxylipin levels associated with preterm birth in preterm labor✰

Cited by 6 publications

References 29 publications

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids

Bioactive metabolites of OMEGA-6 and OMEGA-3 fatty acids are associated with inflammatory cytokine concentrations in maternal and infant plasma at the time of delivery

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