“…CYP2B6 is a cytochrome P450 enzyme that is primarily expressed in the liver and metabolizes many different chemicals, including xenobiotics such as various pesticides, plasticizers, and several pharmaceuticals, steroids such as testosterone and estradiol, and polyunsaturated fatty acids such as linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid (DHA) [ 11 , 12 , 13 , 14 , 15 ]. Several PUFA metabolites (oxylipins) are associated with high-fat diet-induced steatosis in hCYP2B6-Tg mice, including 14,15-EET, PGF2a, 9-HODE, and 13-KODE, and to a lesser extent, 11,12-EET, 14,15-DHET, and 9,10-DiHOME.…”