Plasma nitrate and nitrite levels of patients with eating disorders

Suzuki, Emiko; Mizushima, Hiroko; Ono, Yutaka; Yokoyama, Masamoto; Miyaoka, Hiroaki

doi:10.1046/j.1440-1819.2003.01128.x

Cited by 5 publications

(3 citation statements)

References 8 publications

(8 reference statements)

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“…However, little is still known about the relationship between NO and ED. 9 NO is a free radical that is constantly produced/ released throughout the body by diverse tissue. 10 Thereby, it is presumably part of numerous pathophysiologic processes and pathways.…”

Section: Introductionmentioning

confidence: 99%

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Vignini

D'Angelo

Nanetti

et al. 2009

Intl J Eating Disorders

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Section: Introductionmentioning

confidence: 99%

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Vignini

D'Angelo

Nanetti

et al. 2009

Intl J Eating Disorders

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“…In fact, Vannacci et al, demonstrated that plasma nitrite and cGMP levels were significantly higher in ED patients than in controls (Vannacci et al 2006) while, on the contrary, Suzuki et al, failed to find any difference (Suzuki et al 2003). Thus, in the present study AN lipoproteins were incubated, at different times, with human astrocytoma cells, and NO and peroxynitrite production, inducible, and neuronal nitric oxide synthases (iNOS and nNOS) expression by western immunoblot, were evaluated.…”

Section: Introductionmentioning

confidence: 64%

Lipoproteins Obtained from Anorexia Nervosa Patients Induce Higher Oxidative Stress in U373MG Astrocytes Through Nitric Oxide Production

et al. 2007

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Eating disorders (ED) are a group of important psychiatric disorders that affect young men and women, and can have serious consequences. Among all ED, anorexia nervosa (AN) is the most typical but also the most severe. The pathogenesis of AN is multifactorial and a great variety of cognitive deficits may contribute to its pathogenesis. The present study is aimed to measure NO and peroxynitrite production, iNOS and nNOS expression by Western immunoblot after incubation of AN lipoproteins at different times with human astrocytoma cells. The AN-HDL treated cells showed an increased production of NO at 3 h versus control-HDL treated cells and a decreased production at 24 h. Regarding LDL, a significant increase of NO production was obtained both at 3 and 24 h. The AN-HDL and AN-LDL treated cells showed an increased production of peroxynitrite both at 3 and 24 h compared to control lipoproteins. Densitometric analysis of bands indicated that both iNOS and nNOS protein levels were significantly higher in the cells incubated with AN lipoproteins compared to cells incubated with control lipoproteins both at 3 and 24 h. Although the pathogenesis of AN remains uncertain, evidence exists that modifications to the lipoprotein profile and cholesterol, structural alterations of phospholipids and integral constituents of myelin and synaptosomes may be related to psychotic disorders and body image distortion common to AN. Thus, a relevant pathophysiological association between NO and depression is certainly a possibility, as well as a central role played by NO in the pathogenesis.

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“…Although nitric oxide itself is weakly toxic, when NO is produced at higher concentrations or when it forms reactive nitrogen species, nitric oxide may be associated with several pathologies such as cancer, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, cerebral ischemia, stroke, anxiety and epilepsy. [4,9,10] In addition, NO plays an important role in many psychiatric disorders such as schizophrenia, [11,12] bipolar affective disorders, [13] substance abuse, [14] autism [15,16] and disruptive behavioural disorder. [17] As well as being a cellular messenger, NO is also generated in intracellular organelles at high concentrations where it is used to destroy infectious agents.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence of 1,2‐Diaminoanthraquinone and its Nitric Oxide Reaction Product within Macrophage Cells

et al. 2011

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show abstract

Plasma nitrate and nitrite levels of patients with eating disorders

Cited by 5 publications

References 8 publications

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Anorexia nervosa: A role for L‐arginine supplementation in cardiovascular risk factors?

Lipoproteins Obtained from Anorexia Nervosa Patients Induce Higher Oxidative Stress in U373MG Astrocytes Through Nitric Oxide Production

Fluorescence of 1,2‐Diaminoanthraquinone and its Nitric Oxide Reaction Product within Macrophage Cells

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