Plasma myostatin measured by a competitive ELISA using a highly specific antiserum

Wintgens, Karl Florian; Dschietzig, Thomas; Stoeva, Stanka; Paulsson, Mats; Armbruster, Franz Paul

doi:10.1016/j.cca.2012.04.023

Cited by 27 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…developed (Wintgens et al, 2012). Additionally, differences in study populations could have affected the outcome; especially, the presence of obesity and comorbidities such as diabetes may alter myostatin levels (Brandt et al, 2012;Hittel et al, 2009).…”

Section: Discussionmentioning

confidence: 97%

Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

Hofmann

Halper

Oesen

et al. 2015

Experimental Gerontology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

Hofmann

Halper

Oesen

et al. 2015

Experimental Gerontology

View full text Add to dashboard Cite

“…It measured full-length myostatin peptide with high specificity. The test sensitivity was 270 pg/ml, and the intra- and inter-assay variabilities were less than 10% and 15%, respectively [16]. Briefly, the serum samples was thawed and diluted for 5 folds with provided dilution buffer.…”

Section: Methodsmentioning

confidence: 99%

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

et al. 2014

View full text Add to dashboard Cite

AimsMyostatin is a negative regulator of skeletal muscle mass and may also modulate energy metabolism secondarily. We aim to investigate the relationship between serum myostatin and the metabolic variables in diabetic (DM) and non-diabetic subjects.Materials and MethodsA cross-sectional study recruiting 246 consecutive DM patients and 82 age- and gender-matched non-diabetic individuals at a medical center was conducted. The variables of anthropometry and blood chemistry were obtained. Serum myostatin level was measured with enzyme immunoassay.ResultsDM group had lower serum myostatin compared with non-diabetics (7.82 versus 9.28 ng/ml, p<0.01). Sixty-two percent of the recruited individuals had metabolic syndrome (MetS). The patients with MetS had significantly lower serum myostatin than those without (7.39 versus 9.49 ng/ml, p<0.001). The serum myostatin level decreased with increasing numbers of the MetS components (p for trend<0.001). The patients with higher body mass index, larger abdominal girth, lower high-density lipoprotein cholesterol (HDL-C), and higher triglycerides had lower serum myostatin than those without. The serum myostatin level was independently negatively related to larger abdominal girth, higher triglycerides, and lower HDL-C after adjustment. The odds ratios for MetS, central obesity, low HDL-C, high triglycerides, and DM were 0.85, 0.88, 0.89, 0.85, and 0.92, respectively, when serum myostatin increased per 1 ng/mL, in the binary logistic regression models.ConclusionsLower serum myostatin independently associated with MetS, central obesity, low HDL-C, and high triglycerides after adjustment. Higher serum myostatin is associated with favorable metabolic profiles.

show abstract

“…Our results have been supported by previous reports that serum myostatin levels were decreased in HF patients with compensatory status, cachexia, or with treatment of exercise training. [9,24,25] Previous animal study reported that myostatin levels were increased in muscle atrophy due to denervation (a model of disuse), and stretching and electrical stimulation to muscle, which mimic exercise training, decreased myostatin levels. [26] Therefore, serum myostatin levels depend on the various conditions including severity of HF and treatment including exercise therapy.…”

Section: Discussionmentioning

confidence: 99%

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Furihata

Kinugawa

Fukushima

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

show abstract

Plasma myostatin measured by a competitive ELISA using a highly specific antiserum

Cited by 27 publications

References 26 publications

Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Contact Info

Product

Resources

About