Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

Hofmann, Marlene; Halper, Barbara; Oesen, Stefan; Franzke, Bernhard; Stuparits, Petra; Tschan, Harald; Bachl, Norbert; Strasser, Eva-Maria; Quittan, Michael; Ploder, Martin; Wagner, Karl‐Heinz; Wessner, Barbara

doi:10.1016/j.exger.2015.02.008

Cited by 56 publications

(65 citation statements)

References 50 publications

(63 reference statements)

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“…Yet, data for the relationship between circulating myostatin and agerelated muscle loss have been scarce and conflicting. While an earlier study reported significant elevations in serum myostatin levels with advancing age and declining lean mass (Yarasheski et al 2002), more recent studies had failed to support these findings (Hofmann et al 2015;Ratkevicius et al 2011). Intriguingly, we have observed myostatin to confer deleterious effects for sarcopenia only in older male adults that, if corroborated, has important clinical significance in selection of individuals most likely to benefit from myostatin blocking therapy.…”

Section: Discussionsupporting

confidence: 47%

“…However, subgroup analysis by gender revealed that IGF-1 was associated with sarcopenia only in women, with similar levels being observed in sarcopenic and non-sarcopenic male subjects, although subsequent multiple regression models suggested that the observed influence of IGF-1 in women was largely driven by the effect of age. The gender-specific association between body composition and IGF-1 has been contradictory (Payette et al 2003;Hofmann et al 2015; Goodman-Gruen and Barrett-Connor 1997; Harris et al 1997) . Contrary to the earlier studies that had defined sarcopenia based simply on muscle mass measurements, we had incorporated performance-based measures in defining sarcopenia, and our observed sex-specific influence of IGF-1, albeit not fulfilling statistical significance in the multiple regression models, is in line with an earlier study demonstrating correlation between muscle power and IGF-1 in older women but not in men (Kostka et al 2000).…”

Section: Discussionmentioning

confidence: 99%

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Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

127

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With considerable variation including potential sex-specific differential rate of skeletal muscle loss, identifying modifiable factors for sarcopenia will be pivotal to guide targeted interventions. This study seeks to identify clinical and biological correlates of sarcopenia in community-dwelling older adults, with emphasis on the role of anabolic and catabolic stimuli, and special reference to gender specificity. In this crosssectional study involving 200 community-dwelling and functionally independent older adults aged ≥50 years, sarcopenia was defined using the Asian Working Group for Sarcopenia criteria. Comorbidities, cognitive and functional performance, physical activity and nutritional status were routinely assessed. Biochemical parameters included haematological indices, lipid panel, vitamin D level, anabolic hormones [insulin-like growth factor-1 (IGF-1), free testosterone (males only)] and catabolic markers [inflammatory markers (interleukin-6, Creactive protein) and myostatin]. Multiple logistic regression was performed to identify independent predictors for sarcopenia. Age was associated with sarcopenia in both genders. Malnutrition conferred significantly higher odds for sarcopenia in women (OR=5.71, 95 % CI 1.13-28.84.44, p=0.035) while higher but acceptable range serum triglyceride was protective in men (OR=0.05, 95 % CI 0.00-0.52, p=0.012). Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR=1.11, 95 % CI 1.00-1.24, p=0.041). Serum IGF-1 was significantly lower amongst female sarcopenic subjects, with demonstrable trend for protective effect against sarcopenia in multiple regression models, such that each 1 ng/ml increase in IGF-1 was associated with 1 % decline in odds of sarcopenia in women (p=0.095). Our findings support differential pathophysiological mechanisms for sarcopenia that, if corroborated, may have clinical utility in guiding sex-specific targeted interventions for community-dwelling older adults.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

127

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“…Those efforts included the search for the circulating blood factors that could be identified as biomarkers of aging [1]. Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as such factors that could potentially modify biological age [2, 3]. …”

Section: Introductionmentioning

confidence: 99%

Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

et al. 2018

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BackgroundMyostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological aging. The study aimed to test whether there is a relationship between these plasma circulating proteins and muscle strength, power and optimal shortening velocity (υopt) of older adults.MethodsThe cross-sectional study included 56 women and 45 men aged 60 years and older. Every participant underwent examination which included anthropometric and bioimpedance analysis measurements, functional and cognitive performance tests, muscle strength of upper and lower extremities, muscle power testing with two different methods and blood analyses.ResultsWomen had higher plasma levels of myostatin and GDF11 than men. Men had higher plasma level of follistatin than women. In women, plasma level of myostatin was negatively correlated with left handgrip strength and υopt. Follistatin was negatively correlated with maximum power output (Pmax), power relative to kg of body mass (Pmax∙kg− 1) (friction-loaded cycle ergometer) and power at 70% of the 1-repetition maximum (1RM) strength value (P70%) of leg press (Keiser pneumatic resistance training equipment), and positively correlated with the Timed Up & Go (TUG) test. GDF11 was negatively correlated with body mass, body mass index, waist circumference, fat mass and the percentage of body fat. In men, there were no significant correlations observed between circulating plasma proteins and muscle function measures.ConclusionsThe circulating plasma myostatin and follistatin are negatively associated with muscle function in older women. There is stronger relationship between these proteins and muscle power than muscle strength. GDF11 has a higher association with the body mass and composition than muscle function in older women.

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“…Currently, the National Institute of health (NIH) classifies older women as dynapenic if absolute grip strength (aGS) is < 19.9 kg [11]. A lower aGS has been associated with decreased mobility measured by different clinical and laboratory functional capacity tests such as gait speed [11,12], chair rise test [13,14], six minute walking test [13], step test [14] and one leg stance test [14]. Some authors have suggested the use of body weigth-adjusted grip strenght as a better predictor of fuctional impairments [15,16].…”

Section: Introductionmentioning

confidence: 99%

Is a decrease of grip strength associated with community mobility restriction in dynapenic older women?

Blamoutier¹,

Boissy

Brière³

et al. 2018

JCSM Clinical Reports

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Aims Absolute grip strength (aGS) measures are not only used to detect dynapenia, but can also provide a robust indicator of functional impairments such as mobility limitations. Mobility limitations can impact community mobility. The main objective of this study was to investigate whether dynapenia status measured with aGS can be used as a predictor of the level of community mobility measured by Global Positioning System (GPS) and the Life-Space Assessment questionnaire (LSA) in healthy older adults. It has been shown that body weight related grip strength (GS/BW) is also a clinical predictor of functional limitation. The secondary objective of the study was to assess the relationship between the community mobility and the GS/BW. Method and resultsThe population studied (n=62) was composed of a dynapenic group of women (aged 66.4 ± 4.8) according to an aGS threshold of ≤ 19.9kg and an age-matched group of women (aged 66.1 ± 5.2) with no detectable dynapenia. Clinical and laboratory evaluations were conducted to measure functional capacity tests, body composition and respiratory capacity. Body weigth related to grip strength (GS/BW) was computed. During 12 days, each participant wore a GPS receiver unit with a data logging =-.67) compared system during waking hours. Transit distance in vehicle per day, Transit distance on foot per day and Ellipse area were extracted from the time series of GPS data (longitude, latitude) collected at 1 Hz. The Life space was assessed using a questionnaire. A Wilcoxon test was used to compare the 2 groups for the community mobility measures. Then, data of the 2 groups were pooled to assess the relationship between GS/BW and community mobility measures. A Spearman correlation was used. The dynapenic group had indeed lower aGS (z=-5.3, p≤.05, r=-.67) and GS/BW (z=-5.3, p≤.05, r=-.67)compared to the non-dynapenic group. Furthermore, we found a lower performance to the step test (z=-2.5, p=.011, r=-.32) and lower walking speed (z=-2.1, p=033, r=-.27) for the dynapenic group. However, no significant differences (Wilcoxon signed-ranks test) were found for community mobility measures with the GPS and the LSA between the two groups. There were significant positive relationships between the GS/BW and one leg stand test (r=.353, p=0.005), step test (r=.409, p=0.001) and walking speed (r=.428, p=0.001). No significant relationship (Spearman correlation test) was found for the GS/BW and community mobility measures with the GPS and the LSA. ConclusionsThis study confirms that aGS and GS/BW are good indicators of mobility limitations measured with clinical and laboratory evaluations. However, grip strength alone should not be considered as an indicator of community mobility restriction in an older adult dynapenic population.

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Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women

Cited by 56 publications

References 50 publications

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

Is a decrease of grip strength associated with community mobility restriction in dynapenic older women?

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