Plasma markers of endothelial dysfunction in patients with hypertensive disorders of pregnancy: a pilot study in a South Indian population

Vinayagam, Vickneshwaran; Bobby, Zachariah; Habeebullah, Syed; Chaturvedula, Latha; Bharadwaj, Shruti

doi:10.3109/14767058.2015.1075200

Cited by 10 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, it is reported that the levels of vWF are increased in HIV ( 189 ). Similar findings have been reported in HDP ( 190 , 191 ). Therefore, more research on vWF in HIV associated HDP is needed in order to provide possible association between the role of HIV infection in HDP.…”

Section: The Role Of Hiv Infection On Haemostatic Profile and Hypertensive Disorders Of Pregnancysupporting

confidence: 91%

The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

Phoswa

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Purpose of the Review: The main objective of this study is to investigate mechanisms associated with gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) in HIV infected pregnant women by looking how placental hormones such as (progesterone and prolactin) and basic haemostatic parameters are regulated in HIV infected pregnancies.Recent Findings: HIV/AIDS are a major global obstetric health burden that lead to increased rate of morbidity and mortality. HIV/AIDS has been associated with the pathophysiology of GDM and HDP. Increased risk of GDM due to highly active antiretroviral therapy (HAART) usage has been reported in HIV infected pregnancies, which causes insulin resistance in both pregnant and non-pregnant individuals. HAART is a medication used for lowering maternal antepartum viral load and pre-exposure and post-exposure prophylaxis of the infant. In pregnant women, HAART induces diabetogenic effect by causing dysregulation of placental hormones such as (progesterone and prolactin) and predispose HIV infected women to GDM. In addition to HIV/AIDS and GDM, Studies have indicated that HIV infection causes haemostatic abnormalities such as hematological disorder, deregulated haematopoiesis process and the coagulation process which results in HDP.Summary: This study will help on improving therapeutic management and understanding of the pathophysiology of GDM and HDP in the absence as well as in the presence of HIV infection by reviewing studies reporting on these mechanism.

show abstract

Section: The Role Of Hiv Infection On Haemostatic Profile and Hypertensive Disorders Of Pregnancysupporting

confidence: 91%

The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

Phoswa

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Platelet-derived EVs were analysed by ELISA in cohorts of pregnant women developing preeclampsia during gestation. The results showed an increase, not only in vWF and endothelin-1, but also in platelet-derived EVs in these women, which suggests EVs represent a valid alternative to already established endothelial biomarkers (Vinayagam et al, 2016). Another study investigating the interconnection between EVs and arterial hypertension, was performed by Preston et al (2003).…”

Section: Platelet-derived Extracellular Vesicles As Biomarkers Of Endmentioning

confidence: 87%

The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair

2019

View full text Add to dashboard Cite

Extracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space. Composed of a lipid bilayer encompassing both soluble cytosolic material and nuclear components, these organelles have been recently described as novel regulators of intercellular communication between adjacent and remote cells. Due to their diversified composition and biological content, they portray specific signatures of cellular activation and pathological processes, their potential as diagnostic and prognostic biomarkers has raised significant interest in cardiovascular diseases. Circulating vesicles, especially those released from platelets, leukocytes, and endothelial cells are found to play a critical role in activating several fundamental cells within the vasculature, including endothelial cells and vascular smooth muscle cells. Their intrinsic activity and immunomodulatory properties lends them to not only promote vascular inflammation, but also enhance tissue regeneration, vascular repair, and indeed resolution. In this review we aim to recapitulate the recent findings concerning the roles played by EVs that originate from different circulating cells, with particular reference to their action on the endothelium. We focus herein, on the interaction of platelet and leukocyte EVs with the endothelium. In addition, their potential biological function in promoting tissue resolution and vascular repair will also be discussed.

show abstract

“…Preeclampsia is one of the great obstetrical syndromes (142–152) and is characterized by utero-placental insufficiency (151, 153–175), an imbalance between angiogenic and anti-angiogenic factors in the maternal plasma (37, 38, 46, 47, 151, 176–211), increased thrombin generation (212–221), platelet aggregation (214, 221–226), endothelial cell dysfunction (51, 110, 156, 161, 227–236), and exaggerated intravascular inflammation (1, 33–39).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the expression of adhesion molecules on cultured endothelial cells is stimulated by factors in the maternal circulation, e.g., pro-inflammatory cytokines that could be detected in patients with preeclampsia (29, 250). Due to the systemic inflammatory response (1, 33–39), endothelial activation/dysfunction (51, 110, 156, 161, 227–236), and the hypercoagulable state in preeclampsia (212–226), adhesion molecules are shed from the surface of cells, and their soluble forms can be detected in the peripheral circulation (16, 22, 25, 28).…”

Section: Discussionmentioning

confidence: 99%

The profiles of soluble adhesion molecules in the “great obstetrical syndromes”*

Docheva

Romero

Chaemsaithong

et al. 2018

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

The results of this study show that endothelial cell activation/dysfunction reflected by the plasma concentration of sE-selectin is not specific to preeclampsia but is present in pregnancies complicated by SGA fetuses, acute pyelonephritis, and fetal death. Collectively, we report that each obstetrical syndrome appears to have a stereotypical profile of soluble adhesion molecules in the peripheral circulation.

show abstract

Plasma markers of endothelial dysfunction in patients with hypertensive disorders of pregnancy: a pilot study in a South Indian population

Abstract: A generalized endothelial dysfunction and poor birth outcomes were observed in hypertensive disorders of pregnancy. There is a spectrum of biochemical derangements related to endothelial dysfunction in GH, EOPE, LOPE and E in that order.

Cited by 10 publications

References 27 publications

The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair

The profiles of soluble adhesion molecules in the “great obstetrical syndromes”*

Contact Info

Product

Resources

About