The profiles of soluble adhesion molecules in the “great obstetrical syndromes”*

Docheva, Nikolina; Romero, Roberto; Chaemsaithong, Piya; Tarca, Adi L.; Bhatti, Gaurav; Pacora, Percy; Panaitescu, Bogdan; Chaiyasit, Noppadol; Chaiworapongsa, Tinnakorn; Maymon, Eli; Hassan, Sonia S.; Erez, Offer

doi:10.1080/14767058.2018.1427058

Cited by 38 publications

(32 citation statements)

References 328 publications

(230 reference statements)

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“…We did not identify any differences in maternal sP-selectin between groups, which is in contrast to a previous study, which reported increased levels in pre-eclampsia (23,26). A potential explanation for this difference lies in the later gestation age at sampling in our study when compared to the previous study.…”

Section: Discussioncontrasting

confidence: 99%

“…The increased maternal sE-selectin in pre-eclampsia is in accordance with previous reports (22,23,25,26). We have now shown that there is also increased placental E-selectin, reflecting the overall endothelial dysfunction associated with preeclampsia.…”

Section: Discussionsupporting

confidence: 92%

“…Concentrations of both soluble (s) E-and P-selectins have been reported to be increased in patients with chronic hypertension with the most severe endothelial dysfunction (21). Previous studies have reported elevated maternal plasma sEselectin concentrations in women with pre-eclampsia, both at the time of delivery (22)(23)(24)(25)(26) and also prior to clinical diagnosis (22). However, the available data concerning both sP-and sL-selectins (22,23,26,27) are conflicting.…”

Section: Introductionmentioning

confidence: 99%

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Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

et al. 2020

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Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that circulating maternal and fetal concentrations and placental expression of selectins would be increased in women with pre-eclampsia and would be associated with the angiotensin receptors (AT1R and AT2R). Maternal and fetal blood and placental tissue was collected at delivery from White European normotensive controls (n = 17) and women with pre-eclampsia (n = 17). Soluble (s) E-, P-and L-selectin protein concentrations were measured by ELISA and placental protein expression was examined by immunohistochemistry. Maternal sE-selectin concentrations were increased in pre-eclampsia (P < 0.001); conversely fetal sE-and sP-selectin levels were lower in pre-eclampsia (P < 0.05 for both). Staining was mainly localized to the syncytiotrophoblast for all selectins. E-selectin expression was increased, while P-selectin was decreased in placental from pre-eclampsia (P < 0.05 for both); no differences were observed for L-selectin expression. Both E-and L-selectin were positively correlated (P < 0.008; P < 0.02) with AT2R placental expression, whilst P-selectin was negatively associated with AT1R (P < 0.005), all only in the pre-eclampsia group. This novel study reports maternal, fetal and placental expression of selectins in pre-eclampsia. The increased E-selectins reflect the endothelial dysfunction, characteristic of pre-eclampsia. In contrast, the reduced P-selectins and the positive association of placental AT2Rs with both E-and L-selectin in pre-eclampsia could be a protective mechanism to limit the endothelial dysfunction.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

et al. 2020

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“…In 1997, Austgulen et al found higher endothelial activation in patients with PE than in healthy pregnant women, indicated by the serum level of sVCAM-1 [ 18 ]. This finding was later confirmed by other studies [ 8 , 9 , 10 ], including the recent one by Docheva et al [ 7 ].…”

Section: Discussionsupporting

confidence: 79%

“…Earlier, the degree of endothelial injury and dysfunction, was expressed by other markers, such as soluble cell adhesion molecules (sCAMs) [ 7 , 8 , 9 ]. Among them, serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) was higher in patients with PE than in healthy pregnant women [ 7 , 8 , 9 ]. In one of the studies it was significantly associated with patients with EOP compared to women with LOP [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia

Kornacki

Wirstlein

Wender-Ożegowska

2020

Life

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With regard to differences in the clinical symptoms of preeclampsia (PE), the degree of endothelial dysfunction may differ between early and late-onset preeclampsia (EOP and LOP). The authors of this study examined it by assessing the endothelial injury level in women with EOP (20 patients) and LOP (20 patients) and in normotensive pregnant women (20 patients) in their late second and third trimesters of pregnancy, using the two markers—the serum concentration of hyaluronan (HA) and the serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1). The serum concentrations of HA and sVCAM-1 did not differ significantly between the EOP and LOP patients. However, these were statistically higher than that of the control group participants (p < 0.05; p < 0.001). A significant correlation between the levels of HA and sVCAM-1 was found both in the entire group of patients with preeclampsia (p = 0.0277) and in women with late-onset disease (p = 0.0364), but not in the patients with early-onset preeclampsia (p = 0.331). The obtained results indicated a comparable level of endothelial injury in the two types of PE. The presence of a similar degree of endothelial injury in patients with EOP and LOP should create awareness among all clinicians about the possible fatal complications in both groups of patients with PE.

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Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the Effects of Aspirin in Gestation and Reproduction trial

Theilen

Campbell

Mumford

et al. 2020

American Journal of Obstetrics and Gynecology

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The profiles of soluble adhesion molecules in the “great obstetrical syndromes”*

Cited by 38 publications

References 328 publications

Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia

Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the Effects of Aspirin in Gestation and Reproduction trial

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