Plasma mannose level, a putative indicator of glycogenolysis, and glucose tolerance in Japanese individuals

Yoshimura, K.; Hirano, Seiki; Takata, Hiroshi; Funakoshi, Shogo; Ohmi, Satoko; Amano, Eri; Nishi, Yuichi; Inoue, Mari; Fukuda, Yoshiharu; Hayashi, Hikari; Taguchi, Tadao; Yamada, Shuhei; Miwa, Ichitomo; Terada, Yoshio; Fujimoto, Shimpei

doi:10.1111/jdi.12622

Cited by 13 publications

(24 citation statements)

References 26 publications

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“…We analyzed data derived from 75-g oral glucose tolerance test (OGTT) involving 75 Japanese individuals without diabetic medication as described previously [sex (M/F): 34/41; age: 65 ± 11 (mean ± SD); BMI: 24.9 ± 3.8 kg/m 2 ] [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…In each group, 25 participants were consecutively recruited. Plasma glucose, immunoreactive insulin (IRI), and mannose were measured using the glucose oxidase method, ELISA, and HPLC, as previously described [ 7 ]. Serum leptin, a biomarker for body fat mass [ 9 ], was measured using ELISA (Quantikine ® ELISA, R&D Systems, Minneapolis, MN, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Serum leptin, a biomarker for body fat mass [ 9 ], was measured using ELISA (Quantikine ® ELISA, R&D Systems, Minneapolis, MN, USA). Although fasting plasma glucose (G 0 ), plasma glucose and mannose 120 min after glucose load (G 120 and M 120 , respectively), fasting plasma mannose (M 0 )-M 120 , and HbA1c were significantly different among the 3 groups, age, sex, BMI, and M 0 were not significantly different [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…Mannose, an epimer of glucose, is a monosaccharide constituent of glycoproteins and glycolipids. In humans, the mean concentrations of plasma mannose are approximately between 40 and 50 μM [ 5 – 7 ]. Interestingly, fasting plasma mannose levels (M 0 ) are higher in the obese subjects compared to those in the lean subjects and are associated with insulin resistance independent of BMI.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, downregulation of mannose phosphorylation occurs in the liver of obese individuals, which may lead to decreased plasma mannose utilization and increase in M 0 [ 4 ]. However, the association between mannose and insulin sensitivity in those with diabetes remains unknown, although insulin resistance plays an important role in the pathogenesis of type 2 diabetes [ 1 ] and dysregulation of plasma mannose levels has been reported in type 2 diabetes [ 6 , 7 ]. This study aimed to investigate the association between mannose and insulin sensitivity in individuals with varying degrees of glucose tolerance.…”

Section: Introductionmentioning

confidence: 99%

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Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Amano

Funakoshi

Yoshimura

et al. 2018

Diabetol Metab Syndr

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BackgroundRecently, an integrated network analysis has revealed dysregulation in the metabolism of mannose, a glucose epimer, in severely obese individuals without diabetes. In addition, fasting plasma mannose levels (M0) are associated with insulin resistance independent of BMI. Since the association between mannose and insulin sensitivity (IS) in those with impaired glucose tolerance remains unknown, we aimed to investigate this association in individuals without severe obesity but with varying degrees of glucose tolerance.MethodsBased on 75 g OGTT data in Japanese individuals without diabetic medication, individuals were classified as having normal glucose tolerance (NGT), impaired glucose metabolism (IGM), or diabetes (DM). In each group, 25 individuals were consecutively recruited [total 75 individuals, age: 65 ± 11 (mean ± SD); BMI: 24.9 ± 3.8 kg/m2]. QUICKI and Matsuda index (MI) were calculated as IS indices. M0 was assayed using HPLC. Normally-distributed loge-transformed (ln-) values were used for MI and leptin.ResultsIn the simple regression analysis, ln-MI was negatively correlated with BMI (NGT: r = − 0.639, IGM: r = − 0.466, DM: r = − 0.613) and ln-leptin (NGT: r = − 0.480, IGT: r = − 0.447, DM: r = − 0.593) in all 3 groups. Ln-MI was not significantly correlated with M0 in NGT (r = 0.241, P = 0.245) and IGT (r = − 0.296, P = 0.152) groups, it was moderately and negatively correlated in the DM group (r = − 0.626, P < 0.001). Similar results were obtained, when QUICKI was used instead of MI as an index of IS. In multiple regression analysis in the DM group, QUICKI (Q) and ln-MI (M) were independently predicted by BMI (Q: β = − 0.413; M: β = − 0.400) and M0 (Q: β = − 0.413, M: β = − 0.426), accounting for 51.2% (P = 0.0004) and 51.2% (P = 0.0004) of the variability, respectively, which was larger than the prediction for BMI alone (Q: 38.4%, M: 37.6%).ConclusionFasting plasma mannose was associated with IS independent of BMI in Japanese individuals with DM.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Amano

Funakoshi

Yoshimura

et al. 2018

Diabetol Metab Syndr

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Monose-modified organic electrochemical transistors for cell surface glycan analysis via competitive recognition to enzyme-labeled lectin

Chen

Yan

et al. 2021

Microchim Acta

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A competitive strategy for glycan determination on cell surface with organic electrochemical transistors (OECTs) has been developed. The carboxylic multi-wall carbon nanotubes were firstly immobilized on the gate interface to cross-link the specific monose with adipic dihydrazide as the linker, which could then competitively recognize horseradish peroxidase (HRP)-labeled lectin with the target monose on the cell surface. The HRP captured on the gate interface through the affinity of lectin to monose finally catalyzed the reduction of hydrogen peroxide to produce the output current signal for detection of cell surface monose under the optimal gate voltage of 0.9 V. Using mannose and galactose groups as the target models, HRP-labeled concanavalin A and peanut agglutinin were used to competitively recognize these groups on both cell surface and gate interface, respectively. The amounts of mannose and galactose on HeLa cells were measured to be 3.41 × 10 8 and 2.92 × 10 8 molecules per cell, respectively. The changes of the mannose and galactose expressions upon external stimulation were also observed with the proposed biosensors, which showed consistent results with flow cytometric analysis, indicating that the OECT-based biosensor is suitable for analysis of different glycan expressions on cell surface.

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Quantification of d-mannose in plasma: Development and validation of a reliable and accurate HPLC-MS-MS method

Campi

Codini

Bisoli

et al. 2019

Clinica Chimica Acta

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Plasma mannose level, a putative indicator of glycogenolysis, and glucose tolerance in Japanese individuals

Cited by 13 publications

References 26 publications

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Monose-modified organic electrochemical transistors for cell surface glycan analysis via competitive recognition to enzyme-labeled lectin

Quantification of d-mannose in plasma: Development and validation of a reliable and accurate HPLC-MS-MS method

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