Plasma lysosomal enzyme activity in acute myocardial infarction

Welman, E; Selvvyn, A. P.; Peters, T J; Colbeck, Jill; Fox, Kim

doi:10.1093/cvr/12.2.99

Cited by 32 publications

(11 citation statements)

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“…Our results are in agreement with those reported by Welman et al (1980) and Inoue et al (2000) who have also shown increased levels of NAG in AMI patients and in patients with coronary artery disease. Though, plasma NAG can arise from other tissues as well, due to complications of MI, yet the elevated activity observed in AMI patients is less likely to be due to that because we monitored NAG activity within just few hours after MI.…”

Section: Discussionsupporting

confidence: 94%

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N-Acetyl-β-D-glucosaminidase in acute myocardial infarction

Iqbal

Kazmi²,

Jafri³

et al. 2003

Exp Mol Med

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A bstractThe objective of the study was to investigate whether the lysosom al enzym e, N -Acetyl-β-D-glucosam inidase (NAG ) activity is increased in plasm a of patients with acute m yocardial infarction (AMI) and to determ ine if there is any association betw een plasm a levels of NAG and severity of m yocardial infarction (M I). N A G activity in plasm a w as m onitored in 69 patients with AMI and 135 norm al healthy subjects using a spectrofluorim etric m ethod. A m odified Aldrich ST elevation score w as used to gauge the severity of MI in term s of size of the infarct. Plasm a NAG levels in AMI patients and norm al healthy subjects w ere found to be 10.92±7.5 U /l and 6.8±2.2 U /l, respectively. These tw o m ean value when com pared by Student's t-test were significantly different P = 0.0001. No statistically significant differences in NAG activity w ere observed in patients in term s of gender, age, location of infarct, tim e from onset of chest pain to blood sam pling in the hospital and size of the infarct.

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Section: Discussionsupporting

confidence: 94%

“…The observed increase of NAG activity in plasma of AMI patients appears to be due to its release from cardiac lysosomes. This is supported by the observation that drugs known to stabilize the lysosomes during experimental myocardial anoxia cause reduction in plasma NAG levels (Welman et al, 1980).…”

Section: Discussionmentioning

confidence: 82%

N-Acetyl-β-D-glucosaminidase in acute myocardial infarction

Iqbal

Kazmi²,

Jafri³

et al. 2003

Exp Mol Med

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“…43 NAG is a lysosomal enzyme widely distributed in body tissue; it is released into serum from cells by exocytosis or from the breakdown of cells. 44 The elevated serum NAG activity may be related to atherosclerosis, elevated serum cholesterol, increased uric acid, 45 and increased oxygen free radicals, which lead to destruction of lysosomal membrane with subsequent release of NAG enzyme. 46 Serum NAG activity has gained increased importance as an aid in the diagnosis of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Renoprotective Effect of Grape Seed Extract against Oxidative Stress Induced by Gentamicin and Hypercholesterolemia in Rats

Salem

2011

Renal Failure

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Rationale: Kidneys are dynamic organs and represent one of the major systems maintaining the body homeostasis; they are affected by many chemicals and drugs. Grape seed extract (GSE) has been targeted to prevent drug-induced renal toxicity. Objectives: This study investigates the possible renoprotective effect of GSE against oxidative stress, renal impairment, and hypercholesterolemia (HC) induced by gentamicin (GM) and cholesterol-enriched diet. Seventy adult male Wistar rats (160 ± 10 g) were divided into seven groups: (1) served as control, (2) GSE, (3) GM, (4) GSE + GM, (5) hypercholesterolemic (HC) group, (6) GM + HC group, and (7) GM + HC + GSE. Kidney functions, inflammatory mediators, cytokines, lipid profile, nitric oxide (NO), cyclic guanosine monophosphate (cGMP), and oxidative and antioxidative stress parameters were assessed in all groups. Main findings: GM induced renal dysfunction, which was exacerbated by the presence of HC as confirmed by laboratory determinations. Administration of GSE attenuated the renal toxicity evidenced in significant reduction in elevated kidney function, inflammatory cytokines as well as lipid profile, NO, cGMP, enzymatic, and nonenzymatic antioxidants. Conclusion: Administration of GSE simultaneously with GM attenuated oxidative stress, diminished renal toxicity, and improved lipid profile induced by GM and HC.

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“…Two studies showed that lysozyme activity was increased in AMI patients (32,33). Hickey et al (34) suggested that increased lysozyme activity may be considered as a part of systemic inflammatory response.…”

Section: Discussionmentioning

confidence: 99%