Plasma lipoprotein particle concentrations in postmenopausal women with unstable coronary artery disease. Analysis of diagnostic accuracy using receiver operating characteristics

Abstract

Abstract. Nielsen NE, Olsson AG, Swahn E (University Hospital, Linko Èping, Sweden). Plasma lipoprotein particle concentrations in postmenopausal women with unstable coronary artery disease. Analysis of diagnostic accuracy using receiver operating characteristics. J Intern Med 2000; 247: 43±52.Background. The contribution of plasma lipids to cardiovascular risk is usually evaluated by measuring plasma concentrations of total cholesterol, triglycerides and HDL cholesterol, and calculating LDL cholesterol concentration. We investigated plasma concentrations of apolipoproteins and lipoprotein particles in women with unstable coronary artery disease (CAD) to evaluate whether these, better than the routine lipid status, could differentiate women with and without coronary atherosclerosis. Methods. Blood samples for lipid analyses were collected from 119 angiographically examined postmenopausal 49±79-year-old women with unstable CAD, and from 101 age-matched controls. Mean plasma concentrations were compared and the discriminatory ability of the different variables were tested using receiver operating characteristics (ROC). Results. At coronary angiography 19% had normal vessels and 81% had coronary atherosclerosis. A disturbed triglyceride metabolism was the most pronounced lipid abnormality in women with unstable CAD and coronary atherosclerosis. ROC showed that none of the evaluated variables had a

Triglycerides + high‐density‐lipoprotein‐cholesterol dyslipidaemia, a coronary risk factor in elderly women: the CArdiovascular STudy in the ELderly

“…Menopause could be one reason. Nielsen et al 28 . suggest that lipoprotein changes reflecting disturbed TG metabolism could be more pronounced in postmenopausal women.…”

Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention

“…Similarly, in the cohort of 28,263 postmenopausal women undergoing a three-year follow-up in the Women's Health Study, 32 among lipid variables, various inflammation markers and homocysteine, the only independent predictors of risk for a cardiovascular event were C-reactive protein and the total cholesterol/HDL cholesterol ratio. Other studies 33,34 have shown the total cholesterol/HDL cholesterol ratio to be the lipid parameter with the greatest predictive power with regard to the presence, severity and extension of coronary atherosclerosis in women.…”

Markers of hypercoagulation and von Willebrand factor in postmenopausal women with unstable coronary artery disease. Discriminatory ability regarding unstable coronary artery disease and coronary atherosclerosis using receiver operating characteristics

“…the utility in clinical practice, regarding unstable CAD or not, as well as coronary atherosclerosis or not, using receiver operating characteristics (ROC). This mode of data representation has been used, for instance, when analysing lipids [10–13], homocysteine [14] and tests for peripheral artery disease [15], but to our knowledge ROC have not been used in previous studies on coagulation variables for the analysis of the results.…”