Markers of hypercoagulation and von Willebrand factor in postmenopausal women with unstable coronary artery disease. Discriminatory ability regarding unstable coronary artery disease and coronary atherosclerosis using receiver operating characteristics

Nielsen, Niels Erik; Siegbahn, Agneta; Swahn, Eva

doi:10.1046/j.1365-2796.2000.00715.x

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…High vWF levels have been associated with CAD (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In the present study patients showed higher plasma vWF levels than controls, but this difference was not significant.…”

Section: Discussioncontrasting

confidence: 68%

“…High levels of vWF have been associated with cardiovascular disorders such as ischemic heart disease, peripheral and pulmonary vascular disease, cerebrovascular disease, left ventricular aneurysm, atrial fibrillation, and deep venous thrombosis, as reviewed by Lip and Blann (1). Some studies have shown that high plasma vWF levels are a significant and independent predictor of cardiovascular risk in subjects with coronary artery disease (CAD) (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), but few studies have exam-D. Simon et al ined the relationships between vWF genotypes and coronary heart disease (12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

Simon

Paludo

Ghisleni

et al. 2003

Braz J Med Biol Res

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High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD.

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Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

Simon

Paludo

Ghisleni

et al. 2003

Braz J Med Biol Res

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“…27 It is otherwise reported that SF may be useful for identification of a hypercoagulable state. 28,29 Based on an early diagnosis of the prethrombotic state (hypercoagulable state), we might prevent the onset of thromboses such as DVT, PE, DIC, or CT and thereby improve the outcome in various underlying diseases, which carry a risk for the development of thrombosis.…”

Section: Soluble Fibrinmentioning

confidence: 99%

Are Fibrin-Related Markers Useful for the Diagnosis of Thrombosis?

Wada

Sakuragawa

2008

Semin Thromb Hemost

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Fibrin-related markers (FRMs), such as fibrin and fibrinogen degradation products (FDPs), D-dimer, and soluble fibrin (SF), are considered to be useful for the diagnosis of thrombosis. However, the evidence for the making of a diagnosis of thrombosis based on FRMs is, as yet, not fully established. Levels of FRMs are significantly elevated in patients with thrombosis, such as deep vein thrombosis, disseminated intravascular coagulation, and so on. In Japan, the D-dimer assay test result might be 2-fold higher than results for those assays commonly used in Europe and North America. The levels of SF are significantly elevated in patients before the onset of thrombosis, thus suggesting that the SF assay is useful not only for the diagnosis of thrombosis but also for diagnosing a prethrombotic state. Overall, elevated levels of FRMs indicate a high risk for thrombosis, and they are thus considered to be useful for the diagnosis of thrombosis.

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“…Statins also influence thrombosis/fibrinolysis system through their direct effect on endothelial cells. Endothelial cells injury leads to a release of several markers of thrombosis/fibrinolysis system such as vWF and tPA [2] which significantly affect endothelial function [22]. Therefore, the antithrombotic effect of statins is partly a result of the depressed release of thrombotic markers from vascular endothelium [23], while they can synergize with the antiplatelet aggregating effect of nitric oxide (NO).…”

Section: Statins and Thrombosis/fibrinolysis Systemmentioning

confidence: 99%

Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina

Tousoulis¹,

Kotsopoulou²,

Antoniades³

et al. 2006

International Journal of Cardiology

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Markers of hypercoagulation and von Willebrand factor in postmenopausal women with unstable coronary artery disease. Discriminatory ability regarding unstable coronary artery disease and coronary atherosclerosis using receiver operating characteristics

Abstract: Abstract. Nielsen NE, Siegbahn A, Swahn E

Cited by 9 publications

References 17 publications

Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease

Are Fibrin-Related Markers Useful for the Diagnosis of Thrombosis?

Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina

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