Plasma lipids and lipoproteins during pregnancy and related pregnancy outcomes

Emet, Turgay; Üstüner, İşık; Güven, Seda Güvendağ; Balık, Gülşah; Ural, Ülkü Mete; Tekın, Yeşim Bayoğlu; Şentürk, Senem; Şahin, Figen Kır; Avşar, Ayşe Filiz

doi:10.1007/s00404-013-2750-y

Cited by 111 publications

(129 citation statements)

References 41 publications

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“…However, factors that infl uence preeclampsia, such as chronic hypertension, obesity, and insulin resistance, share common features with dyslipidemia related to oxidative stress and altered vascular function. Our data showed no signifi cant differences in maternal and fetal lipoprotein concentrations between preeclampsia and normotensive controls, which is in line with previous data on maternal levels ( 26 ). In addition, in the current study the mean BMI was 26 kg/m 2 in both groups ( Table 1 ), suggesting that the abnormal lipid profi le could be associated with obesity ( 27 ), and not necessarily with preeclampsia.…”

Section: Discussionsupporting

confidence: 91%

Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype

Hentschke

Poli-de-Figueiredo

Costa

et al. 2013

Journal of Lipid Research

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Gestational hyperlipidemia is a common factor in pregnancy in which the maternal circulating lipid profile changes from an anabolic to a catabolic state, increasing lipids, especially triglycerides (TGs) and lipoproteins ( 1 ). From the 12th week of gestation, phospholipids, total cholesterol (TC), LDL, HDL, and TGs increase in response to estrogen stimulation and insulin resistance ( 2 ). Thus, during the fi rst two trimesters, it is common to see maternal fat accumulation; however, in the third trimester there is enhanced lipolytic activity and decreased lipoprotein lipase (LPL) activity in the adipose tissue, consequently, fat storage declines or ceases ( 3 ). Early in gestation, the lipids are required to develop the fetal brain and central nervous system ( 4 ), to build cell membranes, and as a precursor of bile acids and steroid hormones ( 2 ). However, a maternal source of lipids is still required until term, but in lower amounts, possibly due to some fetal-derived lipids Abstract Atherosis of spiral arteries in uteroplacental beds from preeclamptic women resemble those of atherosclerosis, characterized by increased plasma lipids and lipoproteins. We hypothesized that: 1 ) lipoprotein receptors/ transporters in the placenta would be upregulated in preeclampsia, associated with increased maternal and fetal lipoprotein concentrations; and 2 ) expression of these would be reduced in preeclamptic placentae from women delivering small-for-gestational-age (SGA) infants. Placental biopsies and maternal and umbilical serum samples were taken from 27 normotensive and 24 preeclamptic women. Maternal/ umbilical cord serum LDL, HDL, total cholesterol, and triglycerides were measured. Placental mRNA expression of lipoprotein receptors/transporters were quantifi ed using quantitative RT-PCR. Protein localization/expression of LDL receptor-related protein 1 (LRP-1) in the preeclamptic placentae with/without SGA was measured by immunohistochemistry. Placental mRNA expression of all genes except paraoxonase-1 ( PON-1 ), microsomal triglyceride transfer protein ( MTTP ), and protein disulfi de isomerase family A member 2 ( PDIA2 ) were observed. No differences for any lipoprotein receptors/transporters were found between groups; however, in the preeclamptic group placental LRP-1 expression was lower in SGA delivering mothers (n = 7; P = 0.036). LRP-1 protein was localized around fetal vessels and Hofbauer cells. This is the fi rst detailed study of maternal/fetal lipoprotein concentrations and placental lipoprotein receptor mRNA expression in normotensive and preeclamptic pregnancies. These fi ndings do not support a role of altered lipid metabolism in preeclampsia, but may be involved in fetal growth. -Hentschke, M. R., C. E. Abbreviations: AGA, adequate-for-gestational-age; BMI, body mass index; FGR, fetal growth restriction; FGR-M, fetal growth restriction without hemodynamic changes; FGR-S, fetal growth restriction with hemodynamic changes; IQR, interquartile range; LDL-R , LDL receptor; LRP-1, LDL receptor-related pro...

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Section: Discussionsupporting

confidence: 91%

Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype

Hentschke

Poli-de-Figueiredo

Costa

et al. 2013

Journal of Lipid Research

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“…This is also related to the finding of Emet and colleagues who found changes in lipid profile in patients who were positive for the 50 g glucose challenge test, with the most significant change in the serum triglyceride level [11]. In contrast to the reported hyperlipidemia, Koukkou et al…”

Section: Toescu Et Al Reported Elevated Serum Triglycerides and Ldl-mentioning

confidence: 71%

Maternal Plasma Lipid Profile in Women Screened for Gestational Diabetes Mellitus (GDM)

Atiba¹,

Olofinbiyi²,

Akintunde³

et al. 2017

OJOG

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Objective: This is to determine the plasma lipid profile status of patients diagnosed with gestational diabetes mellitus. Methodology: Seventy-nine pregnant women between gestational age of 24 and 28 weeks out of which 23 and 16 were diagnosed of having GDM using IADAPSG and WHO guidelines respectively were recruited into the study. Plasma lipid profile was determined among the study groups using standard laboratory techniques. Results: Higher numbers of women were diagnosed with GDM using IASDAPG criteria than when WHO criteria were used. Plasma lipid profile showed no significant difference between women with GDM and Non-GDM irrespective of guidelines used in the diagnosis of GDM. Conclusion: Pregnancy and Gestational Diabetes Mellitus may have influence on lipid metabolism but not likely in the second trimester of pregnancy as observed in our study.

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“…[7,11]. Vitamin D may be an important modifiable risk factor and thus should be considered as a potential target for interventions.…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence shown that an abnormal lipid profile during gestation may increase the risk of cardiovascular disease and result in undesirable outcomes for the mother and the fetus, including preeclampsia [7,8], gestational diabetes mellitus [9,10], intrauterine growth restriction and premature birth [11,12].…”

Section: Introductionmentioning

confidence: 99%

Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy

et al. 2017

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Plasma lipids and lipoproteins during pregnancy and related pregnancy outcomes

Cited by 111 publications

References 41 publications

Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype

Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype

Maternal Plasma Lipid Profile in Women Screened for Gestational Diabetes Mellitus (GDM)

Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy

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