Plasma levels of VLDL- + LDL-cholesterol, HDL-cholesterol, triglycerides and apoproteins B and A-I in a healthy population Influence of Several Risk Factors

Dedonder-Decoopman, E.; Fievet-Desreumaux, C.; Campos, Elisa; Moulin, Solène; Dewailly, P; Sezille, G; Jaillard, J

doi:10.1016/0021-9150(80)90063-5

Cited by 52 publications

(21 citation statements)

References 14 publications

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“…The differences in HDL apolipoprotein A-I values observed in our study between smokers and non-smokers were, however, in terms of percent, smaller than the differences observed in HDL cholesterol values. This finding is consistent with the results reported by other authors (12,14,18). According to studies by Dedonder-Decoopman et al (12) the drop in apolipoprotein A-I values also appears to be dependent on the nümber of cigarettes smoked per day.…”

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1supporting

confidence: 93%

“…This finding is consistent with the results reported by other authors (12,14,18). According to studies by Dedonder-Decoopman et al (12) the drop in apolipoprotein A-I values also appears to be dependent on the nümber of cigarettes smoked per day. Our studies, however, were not able to establish any significant differences between moderate (<20/day) and heavy (>20/day) smokers.…”

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1supporting

confidence: 93%

“…The female smokers with no additional or only one additional risk factor, and the male smokers exhibiting exactly one risk factor, showed HDL apolipoprotein A-I values lower than those of non-smokers and smokers. No statistical difference was evident, however, between male non-smokers and smokers in the subgroup exhibiting no additional risk factors, or between non-smokers and smokers of both sexes with (5,6,(9)(10)(11)(12)(13)(14). However, our study was not able to establish any significant differences between the HDL cholesterol values for moderate (<20/day) and heavy (>20/ day) smokers, among either men or women.…”

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1contrasting

confidence: 85%

“…However, our study was not able to establish any significant differences between the HDL cholesterol values for moderate (<20/day) and heavy (>20/ day) smokers, among either men or women. The negative effect of cigarette smoking becomes more apparent when considered in conjunction with other factors influencing HDL cholesterol level, such äs alcohol consumption (8,12,14), use of oral contraceptives (9,11,14), or physical exercise (7,17).…”

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1mentioning

confidence: 99%

“…It has been demonstrated in various epidemiological studies that cigarette smokers have lower HDL cholesterol levels than non-smokers or ex-smokers (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). On the other hand, there has been little research to date on the potential effects of other components of HDL (e. g. apolipoprotein A-I, apolipoprotein A-II, phosphatidyl choline, sphingomyelin).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

Assmann¹,

Schulte²,

Schriewer³

1984

Clinical Chemistry and Laboratory Medicine

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Summary:In preventive studies of Company employees in Westphalia, HDL cholesterol was measured in the sera of 4933 men and 2365 women, äs well äs HDL apolipoprotein A-I in the sera of 3509 men and 1648 women. Three subgroups were compared: non-smokers = persons who have never smoked; ex-smokers = persons who do not smoke ät present but did in the past; smokers = persons who sinoke cigarettes at present. Mean values for HDL cholesterol and for HDL apolipoprotein A-I were significantly lower in smokers than in non-smokers or in ex-smokers, while there were no differences between the last two groups. These differences appeared in both sexes but were more pronounced in women than in men. To answer the question whether the observed differences are caused by the consumption of cigarettes by itself or whether they are caused by the presence of othef risk factors, further subgroups were compared to assess the influence of the risk factors obesity, hypertension, hypercholesterolaemia, hyperglycaemia and hyperuricaemia. It was found that -regardless of the presence of no, one, two or more risk factors -the frequency of probands with low HDL cholesterpl values (<0.907 mmöl/1 (men); < 1.166 mmol/1 (women)) was about 10% higher in smokers than in non-smokers or ex-smokers. Subgroups based on the number of risk factors did not exhibit the same clear distribution for apolipoprotein A-I values äs were seen for HDL cholesterol. The results are interpreted in the light of the existing literature. Einfluß des Zigarettenrauchens auf die Konzentration von HDL-Cholesterin und HDL-Apolipoprotein A-I im Blutserum -Ergebnisse der prospektiven epidemiologischen Studie bei Betriebsangehörigen in Westfalen

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Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1supporting

confidence: 93%

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1supporting

confidence: 93%

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1contrasting

confidence: 85%

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

Assmann¹,

Schulte²,

Schriewer³

1984

Clinical Chemistry and Laboratory Medicine

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Moderate and Heavy Alcohol Consumption Have No Favorable Effect on Lipid Values

Seppä¹,

Sillanaukee²,

Pitkäjärvi³

et al. 1992

Arch Intern Med

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The Effect of Moderate Alcohol Intake on Serum Apolipoproteins A-I and A-II

Camargo¹

1985

JAMA

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High serum concentrations of apolipoprotein (apo) A-I are associated with a decreased risk of coronary heart disease. To study the effect of alcohol intake on serum apo A-I and A-II concentrations, 24 healthy male drinkers (37.8 +/- 13.9 mL [1.3 +/- 0.5 oz] of ethanol per day, mean +/- SD) were randomized into treatment and control groups after a three-week baseline period. The treatment group abstained from all intake of alcohol for the six weeks following randomization and then reverted to its usual level of intake for a five-week period. The control group continued its usual level of drinking throughout the trial. The concentrations of apo A-I and apo A-II of abstainers decreased significantly compared with the corresponding changes in controls. After drinking was resumed, apo A-I and apo A-II concentrations were significantly increased in the treatment group compared with the corresponding changes in the control group. These results suggest that the association between moderate alcohol intake and reduced risk of coronary heart disease may be mediated in part by increased levels of serum apo A-I or apo A-II, or both.

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Plasma levels of VLDL- + LDL-cholesterol, HDL-cholesterol, triglycerides and apoproteins B and A-I in a healthy population Influence of Several Risk Factors

Cited by 52 publications

References 14 publications

The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

Moderate and Heavy Alcohol Consumption Have No Favorable Effect on Lipid Values

The Effect of Moderate Alcohol Intake on Serum Apolipoproteins A-I and A-II

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