Plasma Levels of Free Amino Acids in Normal Subjects Compared with Patients with Rheumatoid Arthritis.

Borden, Alice L.; Wallraff, Evelyn B.; Brodie, Emily C.; Holbrook, W. Paul; Hill, D. F.; Stephens, C. A. L.; Kent, L J; Kemmerer, A. R.

doi:10.3181/00379727-75-18087

Cited by 27 publications

(7 citation statements)

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“…The concentrations of these substances in patients are not too different. Thus the concentration of gamma globulin in normal synovial fluid is approximately 2.4 mg/ml (9) and the concentration of histidine in normal serum is about 0.1 mM (10)(11)(12)(13)(14)(15)(16). The concentration of gold in serum from patients being treated is about 30 pM (17)(18)(19)(20); in synovial fluid from one patient it was 10 pM (20).…”

Section: Discussionmentioning

confidence: 99%

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Gerber

1974

Arthritis & Rheumatism

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Gold thiomalate (40 pM), penicillamine (40 pM), and histidine (20 pM) inhibit the copper-catalyzed (20 pM) thermal aggregation of human gamma globulin (0.8 mg/ml). At these concentrations, inhibition of gamma globulin aggregation was 87%, 96%, and 99% complete. This effect may be related to the reported suppressive effect of these agents in rheumatoid arthritis and adds support to the hypothesis that the hypohistidinemia of rheumatoid arthritis participates in the pathogenesis of the disease. Gold thiomalate (l), D-penicillamine (2),and L-histidine (3,4) have been reported to be effective in the treatment of rheumatoid arthritis. There is good evidence that aggregated gamma globulin is inflammatory, antigenic, and a stimulus to the formation of rheumatoid factors (5). There is also some evidence for the presence of aggregated gamma globulin in the synovial fluid of patients with rheumatoid arthritis (6,7).

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Section: Discussionmentioning

confidence: 99%

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Gerber

1974

Arthritis & Rheumatism

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“…The free blood histidine concentration has been reported to be statistically significantly decreased in patients with rheumatoid arthritis in 10 (1-10) of 11 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) reports. In two reports (3,9), patients with more active rheumatoid arthritis had smaller serum histidine concentrations than patients with less active disease.…”

Section: Introductionmentioning

confidence: 99%

Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activity.

Gerber¹

1975

J. Clin. Invest.

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A B S T R A C T A study of sera from 285 patients with definite or classical rheumatoid arthritis (including 37 patients receiving no anti-inflammatory drugs) and sera from 67 healthy subjects has confirmed 10 published reports of a statistically significant decreased blood histidine concentration in patients with rheumatoid arthritis. Contrastingly, in sera from 231 patients with a variety of acute and chronic illnesses other than rheumatoid arthritis, no statistically significant hypohistidinemia was observed either in the group as a whole or in association with the administration of aspirin, prednisone, indomethacin, phenylbutazone, or dextropropoxyphene.In the patients with rheumatoid arthritis there was a statistically significant correlation between the serum histidine concentration and the following: Westergren sedimentation rate (r = -0.33, P < 10-'), grip strength (r = 0.26, P < 10'), hematocrit (r= 0.23, P < 10-'), duration of morning stiffness (r =-0.14, P = 10-'), walking time (r = -0.13, P = 10"), latex titer of rheumatoid factor (r = -0.11, P = 0.001), and the duration of arthritis (r = -0.06, P = 0.05). There was no statistically significant association between the serum histidine concentration and the duration of rheumatoid arthritis in the 151 patients with disease of 0-10-yr duration (r = 0.02, P = 0.5), the sex of the patient, or the presence of antinuclear antibody (r = 0.007, P = 0.9). The serum histidine concentration was less in rheumatoid patients receiving steroids (P = 0.00001), gold (P = 0.009), and aspirin (P = 0.15) than in rheumatoid patients not receiving these drugs.

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“…No differences were observed between males and females (Borden et al 1950). I n aged persons the plasma valine, tryptophan, lysine and leucines Physiological variations in urine.…”

Section: Earlier Relevant Investigationsmentioning

confidence: 94%

“…Hippuric acid formation was low and glycine depletion severe (de Vries & Alexander 1948 b; Lemon, Chasen 8r Looney 1952;Lemon, Looney & Chasen 1955). No change was observed in alanine(Looney, Lemon & Chasen 1951) Borden et al (1950). made a microbio-…”

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confidence: 94%

Urinary and Blood Amino Acids in Rheumatoid Arthritis

Kulonen¹,

Kulonen²

1960

Scand J Clin Lab Invest

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Plasma Levels of Free Amino Acids in Normal Subjects Compared with Patients with Rheumatoid Arthritis.

Cited by 27 publications

References 0 publications

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activity.

Urinary and Blood Amino Acids in Rheumatoid Arthritis

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