Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activity.

Abstract

A B S T R A C T A study of sera from 285 patients with definite or classical rheumatoid arthritis (including 37 patients receiving no anti-inflammatory drugs) and sera from 67 healthy subjects has confirmed 10 published reports of a statistically significant decreased blood histidine concentration in patients with rheumatoid arthritis. Contrastingly, in sera from 231 patients with a variety of acute and chronic illnesses other than rheumatoid arthritis, no statistically significant hypohistidinemia was observed either in the group as a whole or in association with the administration of aspirin, prednisone, indomethacin, phenylbutazone, or dextropropoxyphene.In the patients with rheumatoid arthritis there was a statistically significant correlation between the serum histidine concentration and the following: Westergren sedimentation rate (r = -0.33, P < 10-'), grip strength (r = 0.26, P < 10'), hematocrit (r= 0.23, P < 10-'), duration of morning stiffness (r =-0.14, P = 10-'), walking time (r = -0.13, P = 10"), latex titer of rheumatoid factor (r = -0.11, P = 0.001), and the duration of arthritis (r = -0.06, P = 0.05). There was no statistically significant association between the serum histidine concentration and the duration of rheumatoid arthritis in the 151 patients with disease of 0-10-yr duration (r = 0.02, P = 0.5), the sex of the patient, or the presence of antinuclear antibody (r = 0.007, P = 0.9). The serum histidine concentration was less in rheumatoid patients receiving steroids (P = 0.00001), gold (P = 0.009), and aspirin (P = 0.15) than in rheumatoid patients not receiving these drugs.

Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne

“…The PS group had weighed value for inflammatory lesion, pustule, cyst, nodule, and pigmentation (see S1 Table). Consistent with our observations, decreases in serum AAs have been described for several chronic inflammatory disorders, including rheumatoid arthritis, inflammatory bowel disease, and chronic kidney disease [45][46][47]. Concerning dermatology, AAs chelate calcium ions and stimulate exfoliation of the stratum corneum, accelerating the turnover of the stratum corneum [48].…”

Association of Rare Loss-Of-Function Alleles in HAL , Serum Histidine

“…6 Studies have shown that people under oxidative stress or having inflammatory diseases, such as CKD or rheumatoid arthritis, tend to have low histidine levels. 7, 26 Inflammation plays a critical role in atherosclerosis and cardiovascular disease, 27 and pro-inflammatory cytokines are related to the early stages of atherosclerosis, a primary cause of CHD. 28 In the present study, we show that high histidine levels were associated with reduced risk of developing CHD in two independent populations.…”

DanHong injection dose-dependently varies amino acid metabolites and metabolic pathways in the treatment of rats with cerebral ischemia

“…Glycine levels are effectively measured in plasma in both normal patients and individuals with inborn errors of glycine metabolism [26] . A wide range of symptoms, from mental and physical retardation to poor intellectual functioning, emotional instability, tremor, ataxia and psychosis, hallmark elevated blood histidine [27,28] . Based on the analysis of the available data, the occurrence and development of cerebral ischemia involves several abnormal structures and malfunctions [29] , indicating that cerebral www.nature.com/aps Guo ZL et al Acta Pharmacologica Sinica npg ischemia is a typical multi-pathway and multi-system complex disease, which is not induced via a single abnormal pathway or the abnormal expression of a single system [30] .…”