Plasma levels of 8-methoxypsoralen after topical paint PUVA

Pham, Chantal T.; Koo, John

doi:10.1016/0190-9622(93)70068-5

Cited by 32 publications

(19 citation statements)

References 31 publications

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“…In accordance with Pham and Koo [14], we cannot confirm a correlation between the severity of skin lesions in psoriasis and the plasma level of 8-MOP, notably not between PASI score and AUC (fig. 4).…”

Section: Discussionsupporting

confidence: 57%

“…The most important are drug concentration, surface area, vehicle composition and duration of exposure [13,14]. Hence, percutaneous absorption of 8-MOP into the blood during bath therapy may occur.…”

Section: Discussionmentioning

confidence: 99%

“…However in bath PUVA the concentration of psoralens in the water is much lower than in an oil-in-water emulsion and additionally does not penetrate the lipophilic barrier of the skin as easily. Serum levels are usually extremely low or undetectable which implies minimal systemic absorption of psoralens from the PUVA bath [3,6,7,14].…”

Section: Discussionmentioning

confidence: 99%

“…However, they reported a range of less than 10-360 ng/ml for patients undergoing oral PUVA at a dose of 0.4-0.6 mg/kg of body weight. In another publication giving the results of oral PUVA therapy at the same dose of 8-MOP per kilogram of body weight, the average plasma level of 8-MOP at 1 h after drug ingestion was 101 ng/ml [14].…”

Section: Discussionmentioning

confidence: 99%

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High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients

Kappes¹,

Bárta²,

Merkel

et al. 2003

Skin Pharmacol Physiol

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With respect to the clinical advantages known for bath PUVA therapy, it was of interest to compare the plasma levels of 8-methoxypsoralen (8-MOP) in bath therapy with those after oral administration for a better insight into the pharmacokinetics of 8-MOP following different modes of application. Considerable high plasma levels of 8-MOP were observed after bath therapy with interindividual variability. The half-life of plasma 8-MOP was markedly shorter after bath PUVA than after oral application. The pharmacokinetic profile of 8-MOP differs according to the mode of application.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients

Kappes¹,

Bárta²,

Merkel

et al. 2003

Skin Pharmacol Physiol

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“…However, systemic side effects (nausea, headache and long-term risk of cataract formation) have limited its use in certain patients. PUVA was first used to treat palmoplantar psoriasis in 1974 [1], Plasma levels were comparable during oral and PUVA treatments [2][3][4], In contrast to oral treatment, PUVA may eliminate the side ef fect of nausea and headache [5] and decrease the risk of ocular damage [6]; however, the treatment has a potential risk to the patients.…”

Section: Introductionmentioning

confidence: 99%

Pharmacodynamic Measurements of 8-Methoxypsoralen in Human Skin

Liu¹,

Ademola²,

Amin³

et al. 1997

Skin Pharmacol Physiol

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The efficiency of the epicutaneous microcirculation is important to the elicitation of pharmacological effects and percutaneous absorption of drugs. Laser Doppler flowmeter, chroma-meter and measurement of transepidermal water loss (TEWL) were used to assess the extent of skin blood flow, water loss and light absorption induced after topical administration of 8-methoxypsoralen (8-MOP). TEWL monitors barrier function directly, while the chromameter measures the light reflected by the skin. Irrespective of the concentration of 8-MOP applied, there is a good correlation between chromameter and evaporimeter readings. However, different drug concentrations elicited significant differences between laser Doppler flowmetry (LDF) and TEWL readings. The response measured with LDF was faster and greater when compared with the other measurements, suggesting that 8-MOP caused a rapid and intense response in skin blood flow. Superficial responses, such as those produced by light reflectance (chromameter) and transepidermal perturbations, were weaker following topical application of 8-MOP combined with UV irradiation (PUVA). This information may be important in delineating guidelines for the clinical practice and instrumental monitoring of topical 8-MOP. These observations suggest that LDF provides a useful, noninvasive physical technique to monitor skin after PUVA. However, caution should be exercised in the interpretation of physical measurements for evaluating the degree of the clinical vasoresponse produced by PUVA treatment.

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