Plasma levels and redox status of coenzyme Q10 in infants and children

Menke, Thomas; Niklowitz, Petra; Schlüter, B.; Weber, Michael A.; Buschatz, D.; Trowitzsch, E.; Andler, Werner

doi:10.1002/biof.5520200306

Cited by 13 publications

(13 citation statements)

References 44 publications

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“…In both, the patient and the control groups, a negative correlation between the age of the children and the CoQ 10 plasma concentration was found, thus, confirming previous findings (21) that preschoolers have increased CoQ 10 levels in comparison to school‐aged children. While the age ranges in both groups are comparable, the mean age in the patient group shifts in favour of elder children.…”

Section: Discussionsupporting

confidence: 88%

Antioxidant level and redox status of coenzyme Q₁₀in the plasma and blood cells of children with diabetes mellitus type 1

et al. 2008

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Hyperglycaemia has been reported to cause increased production of oxygen free radicals. Oxidative stress may contribute to the pathogenesis of diabetic complications. Coenzyme Q(10) (CoQ(10)) is known for its key role in mitochondrial bioenergetics and is considered as a potent antioxidant and free radical scavenger. This study was conducted to evaluate plasma and blood cell concentrations of CoQ(10) in accordance to its redox capacity in children with diabetes mellitus type 1. CoQ(10) plasma and blood cell concentrations and redox status were measured using high-performance liquid chromatography with electrochemical detection in 43 children with diabetes mellitus type 1 and compared with 39 healthy children. In addition, the diabetic patients were subdivided according to their haemoglobin A1c (HbA1c) values into two groups, that is, those with good control (<8%) and those with poor control (>8%), and the CoQ(10) status was compared between the two groups. Children with type 1 diabetes showed increased plasma levels of CoQ(10) in comparison to healthy children. While CoQ(10) erythrocyte and platelet concentrations did not differ, in the diabetes group, the platelet redox status differed with a significantly increased part of reduced CoQ(10). This difference in concentration and redox status in comparison to healthy controls may be attributed to the subgroup of patients with poor control, as the subdivision of diabetic patients according to their HbA1c values shows. In diabetic children, especially in those with poor control, an increase in plasma concentration and intracellular redox capacity of the antioxidant CoQ(10) may contribute to the body's self-protection during a state of enhanced oxidative stress.

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Section: Discussionsupporting

confidence: 88%

Antioxidant level and redox status of coenzyme Q₁₀in the plasma and blood cells of children with diabetes mellitus type 1

et al. 2008

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“…In contrast, the portion of UN10 relative to TQ10 (UN10/TQ10 ratio) in cord plasma appeared to decrease with age (except in cases of asphyxia, Table III). The median UN10/TQ10 ratio in our cord plasma samples was 24%, similar to that reported in venous cord plasma (26%) and peripheral plasma of neonates 1 – 5 days old (25 – 31%) [50] compared to UN10/TQ10 ratios in the peripheral plasma of infants 1– to 12 months old (9 – 19%), children and adolescents 0– to 17 years old (3 – 4%), and non-pregnant women 26– to 55 years old (9%) (Table III) [45,51]. …”

Section: Resultsmentioning

confidence: 73%

Coenzyme Q10, carotenoid, tocopherol, and retinol levels in cord plasma from multiethnic subjects in Hawaii

Franke

Lai

Morrison

et al. 2013

Free Radical Research

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Coenzyme Q10 (Q10), carotenoids, tocopherols, and retinol are the major circulating lipid-phase micronutrients (LPM) known to help mitigate oxidative damage and prevent chronic diseases. However, the functions of these compounds in newborns are little understood. This is due, in part, to the paucity of studies reporting their concentrations in this population. We measured Q10, carotenoids, tocopherols, and retinol in cord plasma from 100 multiethnic subjects living in Hawaii using HPLC with diode array and electrochemical detection. Appropriate internal standards were used including, for the first time, custom designed oxidized (UN10) and reduced (UL10) Q10 analogues. These compounds reflected the oxidation of UL10 to UN10 that occurred during sample processing and analysis and thus permitted accurate adjustments of natively circulating Q10 levels. All LPM measured were much lower in cord than in peripheral plasma. Cord plasma levels of total carotenoids, tocopherols, and retinol were approximately 10-fold, 3- to 5-fold and 1.5- to 3-fold lower than those in children or women. Cord plasma levels of total Q10 (TQ10; median, 113 ng/mL) were approximately 2-fold or 7- to 9-fold lower than peripheral plasma levels of neonates or children and adults, respectively. In contrast, the UN10/TQ10 ratio was substantially higher in cord (24%) than in peripheral plasma of children (3 – 4%) or adults (9%). Among the 5 ethnic groups in our cohort, no differences were observed in the levels of UN10, UL10, or TQ10. However, significant differences in many of the LPM were observed between ethnicities. More research is needed to explain these phenomena.

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“…The current results are in line with those of Miles et al (32), who found that the redox statuses and total plasma CoQ10 concentrations were similar in younger (0.2-7.6 y) and older children (10.4-17.4 y), though younger children had higher mean lipid-adjusted total CoQ10 concentrations. Likewise, we previously showed a distinct age-dependent decrease in lipid-adjusted CoQ10 plasma concentrations in infants and children (33). Infants in the first to the fourth months of life had higher oxidized proportions of CoQ10 (median 19 vs. 9% in older infants in the first year of life).…”

Section: Discussionmentioning

confidence: 88%

Oxidized proportion of muscle coenzyme Q10 increases with age in healthy children

et al. 2015

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Plasma levels and redox status of coenzyme Q10 in infants and children

Cited by 13 publications

References 44 publications

Antioxidant level and redox status of coenzyme Q₁₀in the plasma and blood cells of children with diabetes mellitus type 1

Antioxidant level and redox status of coenzyme Q₁₀in the plasma and blood cells of children with diabetes mellitus type 1

Coenzyme Q10, carotenoid, tocopherol, and retinol levels in cord plasma from multiethnic subjects in Hawaii

Oxidized proportion of muscle coenzyme Q10 increases with age in healthy children

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Plasma levels and redox status of coenzyme Q10 in infants and children

Cited by 13 publications

References 44 publications

Antioxidant level and redox status of coenzyme Q10in the plasma and blood cells of children with diabetes mellitus type 1

Antioxidant level and redox status of coenzyme Q10in the plasma and blood cells of children with diabetes mellitus type 1

Coenzyme Q10, carotenoid, tocopherol, and retinol levels in cord plasma from multiethnic subjects in Hawaii

Oxidized proportion of muscle coenzyme Q10 increases with age in healthy children

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Antioxidant level and redox status of coenzyme Q₁₀in the plasma and blood cells of children with diabetes mellitus type 1

Antioxidant level and redox status of coenzyme Q₁₀in the plasma and blood cells of children with diabetes mellitus type 1