Oxidized proportion of muscle coenzyme Q10 increases with age in healthy children

Niklowitz, Petra; Scherer, Jürgen; Döring, Frank; Paulussen, Michael; Menke, Thomas

doi:10.1038/pr.2015.124

Cited by 6 publications

(6 citation statements)

References 41 publications

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“…For instance, there are significant variations among different laboratories regarding the reference values of CoQ10 in muscle tissues, which may be attributed to differences in specimen types (Table 4). In Petra Niklowitz's study [39], muscle biopsies were obtained from small samples, while other studies used quadriceps samples or did not specify the muscle type. Additionally, these differences may also arise from variations in homogenization or extraction methods and sampling procedures.…”

Section: Levels Of Coq10 In Human Tissuesmentioning

confidence: 99%

“…Additionally, these differences may also arise from variations in homogenization or extraction methods and sampling procedures. In Niklowitz's research [39], frozen specimens were immediately placed on dry ice after biopsy, and to prevent artificial oxidation during tissue processing, internal standards were added directly to the frozen specimens before homogenization.…”

Section: Levels Of Coq10 In Human Tissuesmentioning

confidence: 99%

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Coenzyme Q10: Does it benefit neurological diseases?

Chen

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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Coenzyme Q10 (CoQ10), a redox-active lipid with significant hydrophobic properties, has been found to have lower levels detected in tissues and organs of individuals with certain chronic diseases. This observation has led to the hypothesis that supplementing Coenzyme Q10 can alleviate symptoms of aging and/or delay the onset of these diseases. As a result, there appears to be a positive influence of CoQ10 in certain neurological diseases, including Alzheimer disease, seizures, amyotrophic lateral sclerosis, and multiple sclerosis. This review would discuss the current complementary methods of CoQ10 and explore its therapeutic potential in the treatment of neurological diseases.

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Section: Levels Of Coq10 In Human Tissuesmentioning

confidence: 99%

Section: Levels Of Coq10 In Human Tissuesmentioning

confidence: 99%

Coenzyme Q10: Does it benefit neurological diseases?

Chen

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

View full text Add to dashboard Cite

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“…Therefore, in view of its dependence upon dietary intake, biosynthesis, and lipoprotein concentration, plasma CoQ status may not truly reflect tissue levels. As reported by some authors, there is no correlation between plasma CoQ concentrations and skeletal muscle or mononuclear cells (MNC) [ 112 , 121 ] or platelets [ 122 ]. There is no agreement in the literature as to whether or not gender and race affects plasma CoQ content; some authors report a significant difference [ 105 , 123 ] while others report no difference [ 104 , 124 , 125 ].…”

Section: Coenzyme Q Determination In Biological Samplesmentioning

confidence: 99%

The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions

Pallotti

Bergamini

Lamperti

et al. 2021

IJMS

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Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its function is closely related to mitochondrial respiration, where it acts as an electron transporter. However, the cellular functions of coenzyme Q are multiple: it is present in all cell membranes, limiting the toxic effect of free radicals, it is a component of LDL, it is involved in the aging process, and its deficiency is linked to several diseases. Recently, it has been proposed that coenzyme Q contributes to suppressing ferroptosis, a type of iron-dependent programmed cell death characterized by lipid peroxidation. In this review, we report the latest hypotheses and theories analyzing the multiple functions of coenzyme Q. The complete knowledge of the various cellular CoQ functions is essential to provide a rational basis for its possible therapeutic use, not only in diseases characterized by primary CoQ deficiency, but also in large number of diseases in which its secondary deficiency has been found.

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“…CoQ 10 can be obtained from the diet although the amount obtained seems to be very low from this source. In blood plasma, CoQ 10 levels have been studied in aging to determine whether they can be considered to be aging-related biomarkers [ 9 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly

et al. 2022

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Coenzyme Q10 (CoQ10) is an essential factor for mitochondrial activity and antioxidant protection of cells, tissues and plasma lipoproteins. Its deficiency has been associated with aging progression in animals and humans. To determine if CoQ10 levels in plasma can be associated with frailty in elderly people (aged > 65), we studied the relationship of CoQ10 levels in blood with other parameters in plasma and with the physical activity and capacity in aged people. Our results indicate that high CoQ10 levels are directly associated with lower cardiovascular risk measured by the quotient total cholesterol/HDL cholesterol. Furthermore, high CoQ10 levels were found in people showing higher physical activity, stronger muscle capacity. CoQ10 also showed a strong inverse relationship with sedentarism and the up and go test, which is considered to be a frailty index. Interestingly, we found gender differences, indicating stronger correlations in women than in men. The importance of the maintenance of CoQ10 levels in elderly people to avoid sarcopenia and frailty in elderly people is discussed.

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Oxidized proportion of muscle coenzyme Q10 increases with age in healthy children

Abstract: The age-related redox shift in muscle tissue suggests changes in antioxidative defense during childhood. The reference values established here provide a necessary prerequisite for diagnosing early CoQ10 deficiency.

Cited by 6 publications

References 41 publications

Coenzyme Q10: Does it benefit neurological diseases?

Coenzyme Q10: Does it benefit neurological diseases?

The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions

Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly

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