Plasma level of soluble P-selectin in patients with rheumatic mitral stenosis and sinus rhythm undergoing percutaneous mitral balloon valvuloplasty

Topaloğlu, Serkan; Aras, Dursun; Ergün, Kumral; Geyık, Bilal; Ayaz, Selime; Çay, Serkan; Çağırcı, Göksel; Tüfekçioğlu, Omaç; Korkmaz, Şule

doi:10.1007/s11239-006-9039-y

Cited by 4 publications

(6 citation statements)

References 34 publications

(33 reference statements)

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“…15,17,18 Levels of sPsel are also raised in patients with mitral valve disease but no AF, and such levels fall upon valve repair. 19 Oxidized low-density lipoprotein (oxLDL) may be a mediator of endothelial and platelet perturbation and may serve as a potential prognostic marker for future cardiovascular events. 20 Kim and colleagues 21 reported that lipoprotein properties of patients with AF are more oxidized and modified with smaller particles size compared to controls.…”

Section: Introductionmentioning

confidence: 99%

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Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation

et al. 2014

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Hypercoagulability in mitral valve disease (MVD), a cause of atrial fibrillation (AF) and stroke, is potentially due to endothelial damage/dysfunction (marked by circulating endothelial cells [CECs]), platelet activation (soluble P-selectin [sPsel], platelet microparticles [PMPs], and soluble CD40 [sCD40]), and oxidized low-density lipoprotein (oxLDL) cholesterol. We measured these variables in 24 patients with MVD as well as in 21 with MVD + AF and compared them with 20 healthy controls (HCs). The CECs and PMPs were measured by flow cytometry; sPsel, oxLDL, and CD40 by enzyme-linked immunosorbent assay. Compared with HCs, sPsel and PMPs were equally higher in MVD and MVD + AF; sCD40 and oxLDL were higher in MVD + AF than in HCs and MVD; and CECs were higher in MVD than in the HCs, with further increases in MVD + AF (all P < .001). We conclude that excess platelet activation is present in MVD regardless of AF, and that increased endothelial damage in MVD is greater when compounded by AF.

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Section: Introductionmentioning

confidence: 99%

“…15,17,18 Levels of sPsel are also raised in patients with mitral valve disease but no AF, and such levels fall upon valve repair. 19…”

Section: Introductionmentioning

confidence: 99%

Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation

et al. 2014

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“…As in chronic obstructive pulmonary disease, pulmonary hypertension is usually present in MS because of the increased left atrial pressure, pulmonary arteriolar constriction and obliterative changes in the pulmonary vascular bed. Thirdly, Topaloglu et al [16] found high sP-selectin levels in MS patients. Also, it was shown that AVP caused P-selectin release.…”

Section: Discussionmentioning

confidence: 99%

“…In light of these data, Topaloglu et al [16] evaluated soluble P-selectin (sP-selectin), which is one of the platelet activation markers, in MS patients. This molecule, a component of the membrane of the alpha and dense granules of platelets, is responsible for the adhesion of platelets to leukocytes or the endothelium.…”

Section: Discussionmentioning

confidence: 99%

Copeptin Level and Copeptin Response to Percutaneous Balloon Mitral Valvuloplasty in Mitral Stenosis

Günebakmaz

Çelik²,

İnanç³

et al. 2011

Cardiology

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We aimed to investigate copeptin levels in mitral stenosis (MS) patients and the behavior of copeptin after hemodynamic improvement achieved by percutaneous balloon mitral valvuloplasty (PBMV). The study involved 29 consecutive symptomatic patients with moderate to severe rheumatic MS who underwent PBMV. Twenty-eight age- and gender-matched healthy volunteers composed the control group. Blood samples for copeptin were obtained immediately before and 24 h after PBMV, centrifuged, then stored at -70°C until assayed. The copeptin level of the patient group was statistically different from that of the control group (61.8 ± 34.4 and 36.8 ± 15.2 pg/ml, respectively; p = 0.001). PBMV resulted in a significant increase in mitral valve area and a significant decrease in transmitral gradient as well as systolic pulmonary artery pressure. While hemodynamic relief was obtained, we detected a statistically significant decline in copeptin levels 24 h after PBMV compared to the baseline levels (from 61.8 ± 34.4 to 44.1 ± 18.2 pg/ml; p = 0.004).

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“…However, previous studies with a larger sample size have shown significant decrease of left atrial Pselectin level at 24 hour, and 4 weeks after PBMV with no significant difference between peripheral and left atrial P-selectin. 4,5 Hasan-Ali et al showed that P-selectin change correlated with the change in left atrial diameter and pulmonary artery systolic pressure after 2 weeks of PBMV procedure in 65 patients. 5 It may take a longer period of altered hemodynamic to reduce left atrial soluble P-selectin in MS patients following PBMV.…”

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confidence: 99%

Secreted Left Atrial P-Selectin in Mitral Stenosis after PBMV: When to Measure

Rohman¹

2015

IJC

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Plasma level of soluble P-selectin in patients with rheumatic mitral stenosis and sinus rhythm undergoing percutaneous mitral balloon valvuloplasty

Abstract: This study suggests that in patients with MS and sinus rhythm sP-selectin level increases probably due to turbulent flow across the stenotic valve. After PMBV sP-selectin shows a progessive decline, which is directly correlated with the increase in MVA.

Cited by 4 publications

References 34 publications

Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation

Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation

Copeptin Level and Copeptin Response to Percutaneous Balloon Mitral Valvuloplasty in Mitral Stenosis

Secreted Left Atrial P-Selectin in Mitral Stenosis after PBMV: When to Measure

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