Plasma leptin and growth hormone levels in the fine flounder (Paralichthys adspersus) increase gradually during fasting and decline rapidly after refeeding

Fuentes, Eduardo N.; Kling, Peter; Einarsdóttir, Ingibjörg Eir; Álvarez, Marco; Valdés, Juan Antonio; Molina, Alfredo; Björnsson, Björn Thrándur

doi:10.1016/j.ygcen.2012.02.019

Cited by 106 publications

(63 citation statements)

References 35 publications

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“…These results are in concordance with the studies in goldfish, flounder, rainbow trout and salmons (Canosa et al, 2005;Fuentes et al, 2012;Gabillard et al, 2006;Pierce et al, 2005;Shimizu et al, 2009). Next, we observed high expression levels of serum GH in both fasted and fed TG common carp, while there is no significant difference between them ( Fig.…”

Section: Gh and Hypothalamic Feeding Regulationsupporting

confidence: 92%

Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP)

Zhong

Song

Wang

et al. 2013

General and Comparative Endocrinology

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Section: Gh and Hypothalamic Feeding Regulationsupporting

confidence: 92%

Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP)

Zhong

Song

Wang

et al. 2013

General and Comparative Endocrinology

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“…While these results are consistent with previous studies, which failed to observe an effect of fasting on lep gene expression in some fish species (Huising et al 2006b, Gorissen et al 2009, Kobayashi et al 2011, Tinoco et al 2012, they also contrast with others where a positive relationship between fasting and hepatic lep mRNA expression has been observed. In rainbow trout (Kling et al 2009), Atlantic salmon (Rønnestad et al 2010, Trombley et al 2012 and fine flounder (Paralichthys adspersus; Fuentes et al 2012), fasting and restricted feeding have been associated with elevated plasma leptin levels. However, in those fish species where feed restriction can cause an increase in plasma leptin levels, the response is only observed after a minimum of 1 week of complete fast or several months of rationed feeding.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, in fish, a clear relationship between energy balance and lep expression has yet to be established. While prolonged fasting has no effect on the expression of liver lep in some species (Huising et al 2006b, Gorissen et al 2009, Kobayashi et al 2011, it decreases (Gorissen et al 2009, Won et al 2012 or increases (Kling et al 2009, Rønnestad et al 2010, Fuentes et al 2012 hepatic lep mRNA levels or leptin plasma levels in others. Thus, while leptin has anorectic actions, the physiological conditions under which it plays a role in the regulation of food intake in fish are still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Hypoxemia-induced leptin secretion: a mechanism for the control of food intake in diseased fish

MacDonald

Alderman

Krämer

et al. 2014

Journal of Endocrinology

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Leptin is a potent anorexigen, but little is known about the physiological conditions under which this cytokine regulates food intake in fish. In this study, we characterized the relationships between food intake, O 2 -carrying capacity, liver leptin-A1 (lep-a1) gene expression, and plasma leptin-A1 in rainbow trout infected with a pathogenic hemoflagellate, Cryptobia salmositica. As lep gene expression is hypoxia-sensitive and Cryptobia-infected fish are anemic, we hypothesized that Cryptobia-induced anorexia is mediated by leptin. A 14-week time course experiment revealed that Cryptobia-infected fish experience a transient 75% reduction in food intake, a sharp initial drop in hematocrit and hemoglobin levels followed by a partial recovery, a transient 17-fold increase in lep-a1 gene expression, and a sustained increase in plasma leptin-A1 levels. In the hypothalamus, peak anorexia was associated with decreases in mRNA levels of neuropeptide Y (npy) and cocaineand amphetamine-regulated transcript (cart), and increases in agouti-related protein (agrp) and pro-opiomelanocortin A2 (pomc). In contrast, in non-infected fish pair-fed to infected animals, lep-a1 gene expression and plasma levels did not differ from those of non-infected satiated fish. Pair-fed fish were also characterized by increases in hypothalamic npy and agrp, no changes in pomc-a2, and a reduction in cart mRNA expression. Finally, peak infection was characterized by a significant positive correlation between O 2 -carrying capacity and food intake. These findings show that hypoxemia, and not feed restriction, stimulates leptin-A1 secretion in Cryptobia-infected rainbow trout and suggest that leptin contributes to anorexia by inhibiting hypothalamic npy and stimulating pomc-a2.

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“…At the onset of refeeding, plasma GH levels decline following a single meal. Thus, plasma GH levels in the fine flounder are strongly linked to nutritional status [106]. In contrast to the direct effects of GH on growing tissues, the systemic effects mediated by hepatic IGFs are influenced by environmental and nutritional status.…”

Section: Balance Between Of Somatic Growth and Metabolismmentioning

confidence: 99%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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Growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle growth. Among the possible growth-regulating pathways in vertebrates, components of the somatotropic axis are thought to have the greatest influence. There is growing body of literature focusing on the somatotropic axis and its role regulating growth in fish. This includes research into growth hormone, upstream hypothalamic hormones, insulin-like growth factors, and downstream signaling molecules. Many of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient metabolism. Signals of other endocrine axes exhibit profound effects on the function of the somatotropic axis in vivo. In this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis, including emerging research using genetic modified models. These studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth. somatic growth, endocrine regulation, fish Citation:

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Plasma leptin and growth hormone levels in the fine flounder (Paralichthys adspersus) increase gradually during fasting and decline rapidly after refeeding

Cited by 106 publications

References 35 publications

Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP)

Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP)

Hypoxemia-induced leptin secretion: a mechanism for the control of food intake in diseased fish

Neuroendocrine regulation of somatic growth in fishes

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