Plasma leptin and adiponectin in COPD exacerbations: Associations with inflammatory biomarkers

Krommidas, Georgios; Κostikas, Κonstantinos; Papatheodorou, Georgios; Koutsokera, Angela; Gourgoulianis, Konstantinos; Roussos, Charis; Koulouris, Nikolaos; Loukides, Stelios

doi:10.1016/j.rmed.2009.08.012

Cited by 80 publications

(48 citation statements)

References 35 publications

(38 reference statements)

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“…The design of this study (monthly telephone communication) may not have allowed for objective evaluation of the indications for COPD hospitalisation during follow-up. Our study involved patients with a male:female ratio of ,9:1; however, this was also the case in previous studies by our group with a similar design [39,40], and may reflect the increased prevalence of COPD in males compared with females in Greece [41]. However, the fact that a simple measure of depressive symptoms, such as the BDI, was a significant predictor of clinically important future outcomes in hospitalised COPD patients supports a possible usefulness for this measure in clinical practice.…”

Section: Discussionmentioning

confidence: 87%

The impact of depressive symptoms on recovery and outcome of hospitalised COPD exacerbations

et al. 2012

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The impact of depressive symptoms on outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has not been thoroughly evaluated in prospective studies.We prospectively enrolled 230 consecutive patients hospitalised for AECOPD, without previous diagnosis of depression. Depressive symptoms were evaluated with Beck's depression inventory. Pulmonary function tests, arterial blood gases, COPD assessment test (CAT) and Borg dyspnoea scale were recorded on admission and on days 3, 10 and 40. Patients were evaluated monthly for 1 year.Patients with depressive symptoms required longer hospitalisation (mean¡SD 11.6¡3.7 versus 5.6¡4.1 days, p,0.001). Clinical variables improved during the course of AECOPD, but depressive symptoms on admission had a significant impact on dyspnoea (p,0.001) and CAT score (p50.012) improvement. Patients with depressive symptoms presented more AECOPD (p,0.001) and more hospitalisations for AECOPD (p,0.001) in 1 year. In multivariate analysis, depressive symptoms were an independent predictor of mortality (hazard ratio 3.568, 95% CI 1.302-9.780) and risk for AECOPD (incidence rate ratio (IRR) 2.221, 95% CI 1.573-3.135) and AECOPD hospitalisations (IRR 3.589, 95% CI 2.319-5.556) in 1 year.The presence of depressive symptoms in patients admitted for AECOPD has a significant impact on recovery and is related to worse survival and increased risk for subsequent COPD exacerbations and hospitalisations in 1 year.

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Section: Discussionmentioning

confidence: 87%

The impact of depressive symptoms on recovery and outcome of hospitalised COPD exacerbations

et al. 2012

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“…The serum adiponectin concentration increases during exacerbations, and its elevated levels are observed even 8 weeks after treatment. 35 Behnes et al 36 suggested that adiponectin might play a role in the pathogenesis of systemic inflammatory response during sepsis. 36 An experimental study on cardiomyocytes from neonatal rats showed that hypoxia-reoxygenation-provoked cell death can be attenuated by pretreatment with levels significantly correlated with BMI (R = -0.38; P <0.001), FFM index (R = -0.44; P <0.001) (FIGURE 1AB), total body water (R = -0.49; P <0.001), muscle mass index (R = -0.46; P <0.001), and resting metabolic rate (R = -0.51; P <0.001).…”

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confidence: 99%

Effect of exacerbation frequency on body composition and serum ghrelin and adiponectin concentrations in patients with chronic obstructive pulmonary disease

Rubinsztajn¹,

Przybyłowski²,

Maskey-Warzęchowska³

et al. 2014

Polish Archives of Internal Medicine

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“…Elevation of plasma adiponectin has been found in patients with stable COPD and also during acute exacerbations of COPD (12). Increased plasma adiponectin has been demonstrated in underweight patients with COPD, and adiponectin levels inversely associate with body mass index (BMI), the degree of airflow limitation, and adverse cardiovascular outcomes (13,14).…”

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confidence: 99%

The Association of Adiponectin with Computed Tomography Phenotypes in Chronic Obstructive Pulmonary Disease

Carolan

Kim

Williams

et al. 2013

Am J Respir Crit Care Med

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Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder associated with systemic manifestations that contribute to its morbidity and mortality. Recent work suggests that biomarker signatures in the blood may be useful in evaluating COPD phenotypes and may provide insight into the pathophysiology of systemic manifestations. Adiponectin, primarily produced by fat cells, has been implicated in the pathophysiology of emphysema. Objectives: To investigate the association of adiponectin with clinical and radiologic COPD phenotypes. Methods: Adiponectin levels were determined in 633 individuals, including 432 individuals with COPD from a cohort of former or current smokers enrolled in the COPDGene study. Univariate and multiple regression analysis were used to examine the association of adiponectin with clinical and physiologic data together with quantitative high-resolution computed tomography parameters. Measurements and Main Results: Multiple regression analysis confirmed that higher plasma adiponectin levels were independently associated with emphysema, decreasing body mass index, female sex, older age, and lower percentage change in prebronchodilator/ post-bronchodilator FEV 1 . Conclusions: The association between plasma adiponectin and computed tomography-assessed emphysema suggests a contribution of adiponectin to the development of emphysema and highlights a role for metabolic derangements in the pathophysiology of emphysema.

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Plasma leptin and adiponectin in COPD exacerbations: Associations with inflammatory biomarkers

Abstract: Our data suggest that both leptin and adiponectin are associated with the systemic inflammatory process during exacerbations of COPD. The most significant associations seem to be those with IL-6 and TNF-alpha.

Cited by 80 publications

References 35 publications

The impact of depressive symptoms on recovery and outcome of hospitalised COPD exacerbations

The impact of depressive symptoms on recovery and outcome of hospitalised COPD exacerbations

Effect of exacerbation frequency on body composition and serum ghrelin and adiponectin concentrations in patients with chronic obstructive pulmonary disease

The Association of Adiponectin with Computed Tomography Phenotypes in Chronic Obstructive Pulmonary Disease

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