Plasma intestinal fatty acid binding protein in neonates with necrotizing entercolitis: A pilot study

Edelson, Mary B.; Sonnino, Roberta; Bagwell, Charles E.; Lieberman, Joshua M.; Marks, William H.; Rozycki, Henry J.

doi:10.1016/s0022-3468(99)90102-1

Cited by 91 publications

(65 citation statements)

References 14 publications

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“…In the present study we obtained samples of plasma and urine in regular intervals of 8 h. This method is in contrast to other publications, in which analyses of single, daily or 24-hour samples of plasma and/or urine are reported [2,4,5,12,13,14,19,20,21], with the one exception being the study of Edelson et al [3]. The obvious advantage is gaining an insight into the clinical course of the disease and associated I-FABP levels.…”

Section: Discussionmentioning

confidence: 93%

“…This gives the clinician the opportunity to select the best possible way to measure I-FABP. Although several studies report on I-FABP measured in plasma [3,4,19] and serum [20], and several others on the use of urinary I-FABP measurements [5,12,13,14], no literature compares both methods. Several positive and negative aspects of both measuring methods can be identified.…”

Section: Discussionmentioning

confidence: 99%

“…Early diagnosis can be difficult, but is essential for immediate start of adequate treatment. Intestinal fatty acid-binding protein (I-FABP) is a promising diagnostic marker for NEC [2,3,4,5]. This cytosolic protein is primarily located in enterocytes of the small intestine and released into the circulation after enterocyte disruption or cell death [2,6,7].…”

Section: Introductionmentioning

confidence: 99%

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Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Schurink¹,

Scholten²,

Kooi

et al. 2014

Neonatology

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Background: Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters. Objectives: To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC. Methods: All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e. IL-6, WBC, platelet count, CRP, pH and lactate). Results: Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms. Conclusion: In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Schurink¹,

Scholten²,

Kooi

et al. 2014

Neonatology

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“…Our results are similar to these findings as we found a higher CK activity in patients with intestinal gangrene as compared to those without, although the difference did not reach statistical significance. Intestinal fatty acid binding protein, an enzyme localized in the villi of jejunum and ileum [30], has been reported to increase early during the clinical course of advanced NEC [31,32], representing a promising marker for advanced NEC. Finally, we did not find previous studies on LDH and GOT activity in infants with advanced NEC and, to the best of our knowledge we are the first to report an increase in LDH activity during NEC associated with bowel necrosis.…”

Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase activity is increased in plasma of infants with advanced necrotizing enterocolitis

et al. 2008

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In infants with necrotizing enterocolitis (NEC), intestinal gangrene defines advanced disease. Since intestinal ischemia is considered a pathogenetic factor for intestinal gangrene, serum activity of mucosal and seromuscular enzymes may be elevated in these patients. Our aim was to evaluate if serum enzymes activity is increased in infants with NEC associated with intestinal gangrene. We performed a retrospective review of the case notes of infants operated on for NEC between 1998 and 2006. Patients with preoperative determination of serum enzymes were included in the study, and were divided into Group A and Group B based on the presence or absence of intestinal gangrene, respectively. Serum activities of alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), and lactate dehydrogenase (LDH) were compared in the two Groups. Values are medians (interquartile range). Thirty-five infants were operated on for NEC in the study period. Eighteen patients fulfilled the inclusion criteria: 12 in Group A and six in Group B. Group A patients had significantly higher LDH activity [1131.0 (1092.0-1300.0) vs. 482.0 (440.0-624.5) IU/L; P < 0.005]. Our findings suggest that LDH activity may be increased in infants with NEC and intestinal gangrene. Its evaluation could be a further tool in the surgical decision making process in infants with NEC.

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“…A mucosasé-rülés hatására felszabaduló I-FABP a vérből és a vizeletből már korai NEC esetén is detektálható, szintje emelkedett az egészséges kontrollszemélyekben mért értékekhez képest. Ezt elsőként Lieberman és mtsai írták le 1997-ben, majd több vizsgálat is igazolta, hogy NECben a nem specifi kus emésztőrendszeri tünetek fellépését követő első nyolc órában mért I-FABP-értékek hasznos diagnosztikus és prognosztikus faktorok lehetnek [12][13][14][15][16]. Schurink és mtsai szignifi kánsan magasabb kezdeti plazma-I-FABP-szintet mértek azoknál a NEC-es csecsemőknél, akiknél később sebészeti beavatkozásra volt szükség, szemben a konzervatív terápiával kezelhető csecsemőkben mért kezdeti plazma-I-FABP-értékekkel [17].…”

Section: Nekrotizáló Enterocolitis Akut Mesenterialis Ischaemiaunclassified

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

et al. 2016

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DebrecenAz intestinalis zsírsavkötő fehérje a zsírsavkötő fehérjék családjába tartozó, a vékony-és vastagbél enterocytáinak citoszoljában termelődő, kis molekulasúlyú fehérje. Az enterocytasejtek membránintegritásának megbomlását köve-tően megjelenik a szisztémás keringésben, és a vesék glomerularis szűrőjén keresztül kiválasztódik a vizeletbe. A szerzők akut és krónikus enterocytakárosodással járó gastrointestinalis kórképekben az intestinalis zsírsavkötő fehérje biomarkerként való használatával kapcsolatos vizsgálatokat tekintik át. Orv. Hetil., 2016, 157(2), 59-64.Kulcsszavak: intestinalis zsírsavkötő fehérje, nekrotizáló enterocolitis, akut mesenterialis ischaemia, coeliakia, gyulladásos bélbetegség, bakteriális transzlokáció Intestinal fatty acid binding protein: marker of enterocyte damage in acute and chronic gastroenterological diseasesIntestinal fatty acid binding protein, a small cytosolic protein abundantly present in mature enterocytes of small and large intestine, has proven to be a sensitive marker for damage to the intestinal epithelium. Upon cellular damage of the enterocyte, intestinal fatty acid binding protein is readily released into the systemic circulation, passes through the glomerular fi lter and can be detected in the urine. In this review, the authors review studies on the application of this protein as a biomarker in acute and chronic gastrointestinal diseases.

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Plasma intestinal fatty acid binding protein in neonates with necrotizing entercolitis: A pilot study

Cited by 91 publications

References 14 publications

Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Intestinal Fatty Acid-Binding Protein in Neonates with Imminent Necrotizing Enterocolitis

Lactate dehydrogenase activity is increased in plasma of infants with advanced necrotizing enterocolitis

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

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