Intestinalis zsírsavkötő fehérje: az                     enterocytakárosodás markere akut és krónikus gasztroenterológiai                     kórképekben

Kocsis, Dorottya; Papp, Mária; Tornai, Tamás; Tulassay, Zsolt; Herszényi, László; Tóth, Miklós; Juhász, Márk

doi:10.1556/650.2016.30336

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…However, reports on the differences in the fecal metabolites profile between the RD infants and healthy (H) infants are limited. Among many fecal metabolites, the changes in fecal amino acids (AAs) and fatty acids (FAs) contributed to reveal the relationship between intestinal diseases and fecal metabolites profile (7,8). On the one hand, fecal proteins profile has been reported to be affected by intestinal diseases, and the significant differences in composition of fecal proteins have been found in patients suffering from intestinal disease, such as a significant increase of calprotectin and lactoferrin in feces of patients with inflammatory bowel disease (9,10).…”

Section: Introductionmentioning

confidence: 99%

Rotavirus-Induced Diarrhea Changes the Proteins, Amino Acids and Fatty Acids Profiles in Fecal Samples of the Infants

et al. 2021

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Background: Rotavirus-induced diarrhea (RD) could cause disorders in food protein and fat metabolism of infants the changes of which have not been clearly revealed; however, relevant studies are limited. Objectives: The aim was to investigate the changes of proteins, amino acids and fatty acids profiles in fecal samples of the infants caused by RD. Methods: A total of 30 fecal samples were collected from 15 RD infants and 15 healthy infants. The compositions of fecal proteins, amino acids and fatty acids profiles in all fecal samples were analyzed using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), automatic amino acid analyzer and gas chromatography (GC), respectively. Results: Compared to H infants, the feces in RD infants had lower contents of proteins with 50 - 55, 79 - 80, and 84 - 85 KDa, meanwhile higher contents of proteins with 67 - 69 KDa. The levels of aspartic acid, threonine, serine, glutamic acid, glycinc, alanine, valine, methionine, isoleucine, leucine, lysine, phenylalanine, histidine, arginine, and proline in the feces from RD infants were significantly lower than that of H infants (P < 0.05). The relative proportions of butyric acid, elaidic acid, linoleic acid, cis-11, 14-icotenic acid, cis-11, 14, 17- epoxyeicosatrienoic acids, cis-13, 16-docosanoic acid, and cis-7, 10, 13, 16,19 docosapentaenoic acid in feces from RD infants decreased significantly compared to those of H infants (P < 0.05). On the contrary, significant increases in the relative proportions of caprylic acid, decanoic acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, myristoleic acid, palmitic acid, cis-10-heptadecaenoic acid, oleic acid, and γ-linoleic acid were found in the; feces of RD infants (P < .05). Conclusions: RD changed the proteins, amino acids, and fatty acids profiles in infants feces, which improved the understanding of relationship between RD and fecal metabolites profile.

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Section: Introductionmentioning

confidence: 99%

Rotavirus-Induced Diarrhea Changes the Proteins, Amino Acids and Fatty Acids Profiles in Fecal Samples of the Infants

et al. 2021

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Research Status and Progress of Diagnosis and Treatment of Post-Traumatic Injury with Acute Gastrointestinal Injury

程

2024

ACM

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Insights Into Long Non-Coding RNA and mRNA Expression in the Jejunum of Lambs Challenged With Escherichia coli F17

Chen

Zhang

et al. 2022

Front. Vet. Sci.

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It has long been recognized that enterotoxigenic Escherichia coli (ETEC) is the major pathogen responsible for vomiting and diarrhea. E. coli F17, a main subtype of ETEC, is characterized by high morbidity and mortality in young livestock. However, the transcriptomic basis underlying E. coli F17 infection has not been fully understood. In the present study, RNA sequencing was conducted to explore the expression profiles of mRNAs and long non-coding RNAs (lncRNAs) in the jejunum of lambs who were identified as resistant or sensitive to E. coli F17 that was obtained in a challenge experiment. A total of 772 differentially expressed (DE) mRNAs and 190 DE lncRNAs were detected between the E. coli F17—resistance and E. coli F17-sensitive lambs (i.e., TFF2, LOC105606142, OLFM4, LYPD8, REG4, APOA4, TCONS_00223467, and TCONS_00241897). Then, a two-step machine learning approach (RX) combination Random Forest and Extreme Gradient Boosting were performed, which identified 16 mRNAs and 17 lncRNAs as potential biomarkers, within which PPP2R3A and TCONS_00182693 were prioritized as key biomarkers involved in E. coli F17 infection. Furthermore, functional enrichment analysis showed that peroxisome proliferator-activated receptor (PPAR) pathway was significantly enriched in response to E. coli F17 infection. Our finding will help to improve the knowledge of the mechanisms underlying E. coli F17 infection and may provide novel targets for future treatment of E. coli F17 infection.

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Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

Cited by 3 publications

References 39 publications

Rotavirus-Induced Diarrhea Changes the Proteins, Amino Acids and Fatty Acids Profiles in Fecal Samples of the Infants

Rotavirus-Induced Diarrhea Changes the Proteins, Amino Acids and Fatty Acids Profiles in Fecal Samples of the Infants

Research Status and Progress of Diagnosis and Treatment of Post-Traumatic Injury with Acute Gastrointestinal Injury

Insights Into Long Non-Coding RNA and mRNA Expression in the Jejunum of Lambs Challenged With Escherichia coli F17

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