Plasma insulin, growth hormone, cortisol, and central obesity among young Chinese type 2 diabetic patients.

Lee, Z. S. K.; Chan, Juliana C.N.; Yeung, V. T. F.; Chow, Chun‐Chung; Lau, Michael; Ko, G. T. C.; Li, J. K. Y.; Cockram, Clive S.; Critchley, J. A. J. H.

doi:10.2337/diacare.22.9.1450

Cited by 82 publications

(76 citation statements)

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“…This result was in parallel with previous preliminary data which suggested that circulating cortisol concentrations were higher in patients with MS compared with healthy subjects, both in basal conditions and during dynamic stimulation [36,37]. In studies that included subjects with type 2diabetes alone, elevated basal plasma cortisol levels [38] have been also reported. In contrast, some studies have reported no association between cortisol and MS [39,40].…”

Section: Discussionsupporting

confidence: 81%

Relationship Between IGF-1 and Cortisol/ DHEA-S Ratio in Adult Men With Diabetic Metabolic Syndrome Versus Non-Diabetic Metabolic Syndrome

El-Eshmawy

2011

J Endocrinol Metab

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Background: Metabolic syndrome (MS) is a strong risk factor for cardiovascular disease and type 2 diabetes mellitus. Previous studies have suggested that low insulin like growth factor-1 (IGF-1), low dehydroepiandrosterone sulfate (DHEA-S) and high cortisol are signifi cant correlates of MS. The aim of the present study was to examine the relationships between serum IGF-1, cortisol, DHEA-S and cortisol/ DHEA-S ratio in adult men with MS either diabetic or non-diabetic.

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Section: Discussionsupporting

confidence: 81%

Relationship Between IGF-1 and Cortisol/ DHEA-S Ratio in Adult Men With Diabetic Metabolic Syndrome Versus Non-Diabetic Metabolic Syndrome

El-Eshmawy

2011

J Endocrinol Metab

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“…Therefore, the chronic consumption of high-GI foods, which would result in recurring, large postprandial fluctuations in blood glucose and insulin levels, could worsen insulin resistance in susceptible populations . The insulin resistance syndrome is already prevalent in young adults in diabetic-prone populations, including Chinese and other Asian populations (Lee et al, 1999). In Australia, Vietnamese women have one of the highest rates of gestational diabetes (Beischer et al, 1991;Shelly-Jones et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

The glycaemic index values of Vietnamese foods

et al. 2001

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Objective: To determine and compare the glycaemic index (GI) values of a range of Vietnamese foods in two racial groups. Design and subjects: Twelve healthy subjects (six Asian and six Caucasian) consumed 50 g carbohydrate portions of a reference food (glucose sugar) and nine Vietnamese foods (three rices, three noodle products and three sweet foods) in random order after an overnight fast. The reference food was tested on two separate occasions, and the Vietnamese foods were each tested once. Capillary blood samples were taken at time 0 (fasting), 15, 30, 45, 60, 90 and 120 min from the start of each meal. Samples were analysed for plasma glucose and the incremental areas under the plasma glucose curves (AUC) were used to calculate the GI values of the test foods, using glucose as the reference food (ie GI value of glucose ¼ 100). The mean GI value of each food was calculated for the entire group of subjects (n ¼ 12) and for both racial groups (n ¼ 6). Results: The three rices had surprisingly high GI values (86 -109), whereas the noodle products had relatively low GI values (39 -61). The sugar-rich foods produced intermediate GI values (54 -79). The GI values for the nine foods calculated separately for the two racial groups were not significantly different from each other (P ¼ 0.26). Conclusions:The GI values derived from Caucasian subjects are likely to be applicable to Asian populations. Varieties of imported rice from Thailand were found to have high GI values. Alternative low-GI staples, such as rice noodles, may be preferable for Asian=Vietnamese people with diabetes. Sponsorship: This study was funded by the University of Sydney.

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“…The activity of the HPA axis shows a clear circadian rhythm exhibiting a rapid rise during the latter half of the sleep cycle, with the highest levels occurring in the early morning (18) in parallel with the timecourse change of BP (19), suggesting the involvement of a diurnal change in HPA axis in the generation of MBPS. It was reported that T2DM patients exhibit higher baseline levels of serum cortisol (20). Although we did not monitor the diurnal change of serum cortisol in the current study, its serum level at 8:00 A.M. was significantly higher in those with insulin resistance than in those without.…”

Section: Discussionmentioning

confidence: 48%

Association Between Glycemic Control and Morning Blood Pressure Surge With Vascular Endothelial Dysfunction in Type 2 Diabetic Patients

et al. 2014

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OBJECTIVEMorning blood pressure surge (MBPS) is an independent predictor of cardiovascular events. However, little is known about the association between glycemic control and MBPS, and its effect on vascular injury in patients with type 2 diabetes mellitus (T2DM). The current study examined the association between glycemic control and MBPS, and the involvement of MBPS in the development of vascular dysfunction in T2DM patients. RESEARCH DESIGN AND METHODSWe examined MBPS in T2DM patients (25 male patients/25 female patients; mean age, 60.1 6 13.2 years; n = 50) using 24-h ambulatory blood pressure monitoring, and assessed vascular function by brachial artery flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD). RESULTSHbA 1c (r = 0.373, P = 0.009) and triglyceride (TG) (r = 0.375, P = 0.009) levels correlated significantly and positively with MBPS. In multiple regression analysis, including TG and HbA 1c levels in addition to age and 24-h systolic blood pressure (SBP) as independent variables, HbA 1c (b = 0.328, P = 0.016) and TG (b = 0.358, P = 0.014) were associated significantly in a positive manner with MBPS. In a noninsulin user, when homeostasis model assessment ratio (HOMA-R) was included in place of TG, HOMA-R emerged as a significant factor. MBPS (r = 20.289, P = 0.043) and HbA 1c (r = 20.301, P = 0.035) correlated significantly and negatively with FMD, whereas 24-h SBP correlated with both FMD (r = 20.359, P = 0.012) and NMD (r = 20.478, P = 0.004). In multiple regression analysis, including age, gender, 24-h SBP, MBPS, LDL cholesterol, and HbA 1c , MBPS (b = 20.284, P = 0.044) alone associated significantly in a negative manner with FMD, but not with NMD. CONCLUSIONSThe current study demonstrated that poor glycemic control and insulin resistance are independently associated with the occurrence of MBPS in T2DM patients, which might be significantly associated with endothelial dysfunction.

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Plasma insulin, growth hormone, cortisol, and central obesity among young Chinese type 2 diabetic patients.

Cited by 82 publications

References 0 publications

Relationship Between IGF-1 and Cortisol/ DHEA-S Ratio in Adult Men With Diabetic Metabolic Syndrome Versus Non-Diabetic Metabolic Syndrome

Relationship Between IGF-1 and Cortisol/ DHEA-S Ratio in Adult Men With Diabetic Metabolic Syndrome Versus Non-Diabetic Metabolic Syndrome

The glycaemic index values of Vietnamese foods

Association Between Glycemic Control and Morning Blood Pressure Surge With Vascular Endothelial Dysfunction in Type 2 Diabetic Patients

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