Relationship Between IGF-1 and Cortisol/ DHEA-S Ratio in Adult Men With Diabetic Metabolic Syndrome Versus Non-Diabetic Metabolic Syndrome

El-Eshmawy,

doi:10.4021/jem43w

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…84,85 Increased HPA axis activity is higher in type II diabetes, compared with controls, 86 especially in those with diabetic complications/metabolic syndrome. 86,87 However, reduction in circulating insulin with benfluorex does not alter plasma cortisol levels. 88…”

Section: The Hypothesis and Its Backgroundmentioning

confidence: 99%

Modulation of Tryptophan and Serotonin Metabolism as a Biochemical Basis of the Behavioral Effects of Use and Withdrawal of Androgenic-Anabolic Steroids and Other Image- and Performance-Enhancing Agents

Badawy

2018

Int J�Tryptophan�Res

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Modulation of tryptophan (Trp) metabolism may underpin the behavioral effects of androgenic-anabolic steroids (AAS) and associated image and performance enhancers. Euphoria, arousal, and decreased anxiety observed with moderate use and exercise may involve enhanced cerebral serotonin synthesis and function by increased release of albumin-bound Trp and estrogen-mediated liver Trp 2,3-dioxygenase (TDO) inhibition and enhancement of serotonin function. Aggression, anxiety, depression, personality disorders, and psychosis, observed on withdrawal of AAS or with use of large doses, can be caused by decreased serotonin synthesis due to TDO induction on withdrawal, excess Trp inhibiting the 2 enzymes of serotonin synthesis, and increased cerebral levels of neuroactive kynurenines. Exercise and excessive protein and branched-chain amino acid intakes may aggravate the effects of large AAS dosage. The hypothesis is testable in humans and experimental animals by measuring parameters of Trp metabolism and disposition and related metabolic processes.

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Section: The Hypothesis and Its Backgroundmentioning

confidence: 99%

Modulation of Tryptophan and Serotonin Metabolism as a Biochemical Basis of the Behavioral Effects of Use and Withdrawal of Androgenic-Anabolic Steroids and Other Image- and Performance-Enhancing Agents

Badawy

2018

Int J�Tryptophan�Res

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“…Although cortisol has been largely used as a biomarker of chronic stress both for humans and animals, the additional evaluation of DHEA, and the estimation of their ratio [ 7 , 8 ], is advisable to complete the study of the HPA axis activity. In actual fact, DHEA is indeed reported as a useful marker of HPA axis activity in humans and animals [ 6 , 9 ] with its anti-glucocorticoid properties, as shown in the blood of men with metabolic syndrome [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Hair and Claw Dehydroepiandrosterone Concentrations in Newborn Puppies Spontaneously Dead within 30 Days of Age

Fusi

Veronesi

Prandi

et al. 2022

Animals

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The latest intrauterine fetal developmental stage and the neonatal period represent the most challenging phases for mammalian offspring. Toward the term of pregnancy, during parturition, and after birth, the hypothalamic–pituitary–adrenal axis (HPA) is a key system regulating several physiologic processes, through the production of cortisol and dehydroepiandrosterone (DHEA). This study was aimed to assess DHEA concentrations in hair and claws of 126 spontaneously dead newborn puppies, classified as premature puppies (PRE-P), stillborn puppies (STILL-P) and puppies that died from the 1st to the 30th day of life (NEON-P). The possible influence of newborn sex, breed body size, and timing of death on DHEA concentrations in both matrices was evaluated. Claw DHEA concentrations were higher in the PRE-P group when compared to STILL-P and NEON-P puppies (p < 0.05), whilst no significant differences were found in hair for all the studied factors. The results confirm the hypothesis that higher amounts of DHEA are produced during the intrauterine life in dogs, also in puppies that will die soon after birth.

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The Mechanisms Linking Relative Hypercortisolism - The Common Feature Across COVID-19 Risks - To ARDS, Septic Shock, and Cytokine Dysregulation

Cordell

2020

SSRN Journal

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Relationship Between IGF-1 and Cortisol/ DHEA-S Ratio in Adult Men With Diabetic Metabolic Syndrome Versus Non-Diabetic Metabolic Syndrome

Cited by 3 publications

References 53 publications

Modulation of Tryptophan and Serotonin Metabolism as a Biochemical Basis of the Behavioral Effects of Use and Withdrawal of Androgenic-Anabolic Steroids and Other Image- and Performance-Enhancing Agents

Modulation of Tryptophan and Serotonin Metabolism as a Biochemical Basis of the Behavioral Effects of Use and Withdrawal of Androgenic-Anabolic Steroids and Other Image- and Performance-Enhancing Agents

Hair and Claw Dehydroepiandrosterone Concentrations in Newborn Puppies Spontaneously Dead within 30 Days of Age

The Mechanisms Linking Relative Hypercortisolism - The Common Feature Across COVID-19 Risks - To ARDS, Septic Shock, and Cytokine Dysregulation

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