Plasma <i>α</i>‐synuclein levels are increased in patients with obstructive sleep apnea syndrome

Sun, Hao‐Lun; Sun, Baoqing; Chen, Dong-Wan; Chen, Yang; Li, Weiwei; Xu, Manyu; Shen, Yujie; Xu, Zhi‐Qiang; Wang, Yan‐Jiang; Bu, Xian‐Le

doi:10.1002/acn3.756

Cited by 26 publications

(19 citation statements)

References 41 publications

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“… 156 There is evidence that OSAS due to chronic intermittent hypoxia contributes to the pathogenesis of PD increasing the alfa-synuclein levels. 157 Severe and prolonged hypoxia contributes to brain damage, but moderate hypoxia exerts a neuroprotective effect through HIF-1alfa activation in PD model 158 while low level of HIF-1alfa is associated with neuronal dopaminergic cell loss in the substantia nigra pars compacta (SNpc) and contributes to PD pathogenesis. 159 HIF1alfa pathway is proposed as a therapeutic target for PD.…”

Section: Literature and Research Methodsmentioning

confidence: 99%

Recommendations for traveling to altitude with neurological disorders

Falla

Giardini²,

Angelini

2021

J Cent Nerv Syst Dis

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Background Several neurological conditions might worsen with the exposure to high altitude (HA). The aim of this review was to summarize the available knowledge on the neurological HA illnesses and the risk for people with neurological disorders to attend HA locations. Methods A search of literature was conducted for several neurological disorders in PubMed and other databases since 1970. The neurological conditions searched were migraine, different cerebrovascular disease, intracranial space occupying mass, multiple sclerosis, peripheral neuropathies, neuromuscular disorders, epileptic seizures, delirium, dementia, and Parkinson’s disease (PD). Results Attempts were made to classify the risk posed by each condition and to provide recommendations regarding medical evaluation and advice for or against traveling to altitude. Individual cases should be advised after careful examination and risk evaluation performed either in an outpatient mountain medicine service or by a physician with knowledge of HA risks. Preliminary diagnostic methods and anticipation of neurological complications are needed. Conclusions Our recommendations suggest absolute contraindications to HA exposure for the following neurological conditions: (1) Unstable conditions–such as recent strokes, (2) Diabetic neuropathy, (3) Transient ischemic attack in the last month, (4) Brain tumors, and 5. Neuromuscular disorders with a decrease of forced vital capacity >60%. We consider the following relative contraindications where decision has to be made case by case: (1) Epilepsy based on recurrence of seizure and stabilization with the therapy, (2) PD (± obstructive sleep apnea syndrome-OSAS), (3) Mild Cognitive Impairment (± OSAS), and (4) Patent foramen ovale and migraine have to be considered risk factors for acute mountain sickness.

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Section: Literature and Research Methodsmentioning

confidence: 99%

Recommendations for traveling to altitude with neurological disorders

Falla

Giardini²,

Angelini

2021

J Cent Nerv Syst Dis

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“…Acute hypoxia in the mouse brain has been shown to lead to α‐synuclein upregulation, 31 whereas hypoxia conditioning seems to stabilize α‐synuclein levels 31 . Accordingly, in OSA patients, who experience severe hypoxic episodes during their sleep, α‐synuclein levels are elevated as well 32 . Hypoxic insult‐related upregulation of α‐synuclein levels possibly also favors or increases its aggregation, 33 and cellular acidification in response to hypoxia may increase α‐synuclein – mitochondria interactions 23 .…”

Section: Could Enhancing the Adaptive Response To Hypoxia Be Beneficial In Pd?mentioning

confidence: 99%

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

et al. 2021

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Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how neuroprotective effects can be induced by hypoxia conditioning and how related approaches have the potential to be harnessed as therapeutic strategies in Parkinson's disease. © 2021 International Parkinson and Movement Disorder Society

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“…The exact mechanisms at play are still not fully understood, but, similar to AD, OSA, although not causing the disorder, likely plays a role in promoting or enhancing PD-associated pre-clinical pathological processes. Concurrent with this, Sun et al (2019) (N = 88) reported that both OSA severity and hypoxia markers were associated with increased levels of plasma αsynuclein, a key protein involved in PD pathology, in healthy adults [48]. With the onset of PD, the relationship between OSA and PD becomes more complex.…”

Section: Sleep Apnoea and Parkinson's Diseasementioning

confidence: 93%

The Link Between Obstructive Sleep Apnoea and Neurodegeneration and Cognition

Weihs

Frenzel

Grabe

2021

Curr Sleep Medicine Rep

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Purpose of Review Obstructive sleep apnoea (OSA) is increasingly found to have an impact on neurodegeneration. In this review, we summarise recent findings on the association between OSA and brain morphology, cognition, and processes related to Alzheimer’s dementia (AD) and Parkinson’s disease (PD). Recent Findings Associations between OSA and alterations in grey and white matter, brain diffusivity, and deficits in memory, attention, and executive control were reported. Furthermore, OSA was correlated with higher risks of developing AD and PD and associated pathophysiology. Treatment was found to alleviate but not reverse some of the damage. Summary There are strong indications that OSA plays a major role in neurodegenerative processes. The broad picture however remains elusive, likely due to insufficient sample sizes, heterogeneous outcomes, and OSA definitions failing to quantify the disorder’s sub-processes. While studies resolving these issues are required, the available evidence shows OSA to be a promising target to slow neurodegeneration and delay the onset of related disorders.

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Plasma α‐synuclein levels are increased in patients with obstructive sleep apnea syndrome

Cited by 26 publications

References 41 publications

Recommendations for traveling to altitude with neurological disorders

Recommendations for traveling to altitude with neurological disorders

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

The Link Between Obstructive Sleep Apnoea and Neurodegeneration and Cognition

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