Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men

Chambers, John C.; Obeid, Omar; Refsum, Helga; Ueland, Per Magne; Hackett, D.; Hooper, James; Turner, Rebecca; Thompson, Slmon G; Kooner, Jaspal S.

doi:10.1016/s0140-6736(99)93019-2

Cited by 224 publications

(190 citation statements)

References 18 publications

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“…17 In brief, we investigated 1025 healthy male subjects (518 Indian Asians and 507 European whites), aged 35 to 60 years, who were identified at random from the age-sex registers of 56 local general practitioners. Subjects were contacted by post, and Ͼ50% agreed to take part.…”

Section: Subjectsmentioning

confidence: 99%

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C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites

et al. 2001

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Background-Indian Asians in the United Kingdom have increased coronary heart disease (CHD) mortality compared with European whites, but the causes are not well understood. Increased circulating concentrations of C-reactive protein (CRP) are an independent risk factor for CHD. Therefore, we investigated this marker of inflammation in healthy UK Indian Asian and European white men. Methods and Results-We measured serum CRP concentrations and conventional CHD risk factors in 1025 healthy male subjects (518 Indian Asians and 507 European whites) aged 35 to 60 years who were recruited at random from general practitioner lists. The geometric mean CRP concentration was 17% higher (95% confidence interval, 3% to 33%) in Indian Asians compared with European whites. CRP values were strongly associated with conventional CHD risk factors, measures of obesity, and metabolic disturbances associated with insulin resistance in both racial groups. The difference in CRP concentrations between Indian Asians and European whites remained after adjustment for conventional CHD risk factors but was eliminated by an adjustment for central obesity and insulin resistance score in Asians. On the basis of these results, we estimate that the processes underlying elevated CRP and/or increased CRP production itself are associated with an Ϸ14% increase in population CHD risk among Indian Asians compared with European whites. Conclusions-CRP

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Section: Subjectsmentioning

confidence: 99%

“…Subjects were contacted by post, and Ͼ50% agreed to take part. 17 Indian Asians were classified as those who had all 4 grandparents of North Indian descent; they had resided in the UK for 27Ϯ8 years. European whites were born in the UK.…”

Section: Subjectsmentioning

confidence: 99%

C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites

et al. 2001

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“…The severe hyperhomocysteinemia is seen in 5 -7 % of general population who do not show clinical signs and symptoms of IHD in their early life (4). Much work is done in Indian population on this aspect (5,6), however, there are conflicting reports on the serum Hcy in Indian population (3,5). The molecular mechanism by which Hcy promotes atherosclerosis is unknown.…”

Section: Introductionmentioning

confidence: 99%

Relationship of plasma homocysteine with lipid profile parameters in ischemic heart disease

Yadav

Bhagwat

Rathod

2006

Indian J Clin Biochem

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The present study was undertaken to explore the relationship of plasma homocysteine with other biochemical parameters in ischemic heart disease. Plasma levels of total homocysteine was measured by HPLC -fluorescence detection with internal standard in 60 ischemic heart disease patients and were compared with 30 age matched normal healthy controls. The significant increase of plasma homocysteine was observed in both myocardial infarction and chronic stable ischemic heart disease patients when compared with the controls. The hyperhomocysteinemia appears be to due to increased body demand of vitamins such as folic acid, vitamin B 12 , B 6 , B 2 either alone or in combination to regulate normal homocysteine metabolism.

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“…This led researchers to think of novel risk factors, which might contribute to CAD. Some of the comparative studies on migrant Indians have suggested that the excess risk for CAD seen among Indians could be partly explained by these risk factors [72,73]. Some of the newer risk factors such as lipoprotein (a), homocysteine, coagulation and fibrinolytic factors, inflammatory markers and high-sensitivity C-reactive protein (hs-CRP) are linked with higher risk for CAD.…”

Section: Emerging Risk Factorsmentioning

confidence: 99%

Molecular Studies on Coronary Artery Disease—A Review

Simon

Vijayakumar

2013

Ind J Clin Biochem

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Coronary artery disease (CAD) remains the major cause of mortality and morbidity in the entire world population. The conventional risk factors of CAD include hypertension, hyperlipidemia, diabetes mellitus, family history, smoking etc. These factors contribute only 50 % of the total risk of CAD. For providing a complete risk assessment in CAD, it is mandatory to have well-planned clinical, biochemical and genetic studies in patients with CAD and subjects who are at risk of developing CAD. In this review an attempt is made to critically evaluate the conventional and emerging risk factors which predispose the individual to CAD. Specifically, the molecular basis of CAD including high oxidative stress, low antioxidant status and increased DNA damage are covered. A comprehensive and multifactorial approach to the problem is the better way to reduce the morbidity and mortality of the disease.

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Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men

Cited by 224 publications

References 18 publications

C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites

C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites

Relationship of plasma homocysteine with lipid profile parameters in ischemic heart disease

Molecular Studies on Coronary Artery Disease—A Review

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