Relationship of plasma homocysteine with lipid profile parameters in ischemic heart disease

Abstract

The present study was undertaken to explore the relationship of plasma homocysteine with other biochemical parameters in ischemic heart disease. Plasma levels of total homocysteine was measured by HPLC -fluorescence detection with internal standard in 60 ischemic heart disease patients and were compared with 30 age matched normal healthy controls. The significant increase of plasma homocysteine was observed in both myocardial infarction and chronic stable ischemic heart disease patients when compared with the controls. The hyperhomocysteinemia appears be to due to increased body demand of vitamins such as folic acid, vitamin B 12 , B 6 , B 2 either alone or in combination to regulate normal homocysteine metabolism.

Link between Hyperhomocysteinemia, Glycemic and Lipid Profiles, in Type 2 Diabetes in Côte d'Ivoire

“…We have therefore concluded that there was no correlation between the hyperhomocysteinemia and the lipids. Our study is in agreement with those of De-Luis et al, [20] and Yadav et al, [21] who also had found no correlative link between the lipids and the hyperhomocysteinemia. Corroborating our study, Momin et al, [7] also have found that the total and…”

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

“…In fact, increasing synthesis of Hcy may have an effect on the progression of atherogenesis [23,24]. Yadav et al, however, did not find a significant correlation between plasma Hcy and total cholesterol, HDL cholesterol or triglycerides [25]. Holven et al suggested that hyperhomocysteinaemic individuals have dysfunctional HDL particles with attenuated antiatherogenic activity and that this may represent a novel explanation for the increased risk of cardiovascular events in these individuals [26].…”

Cardiovascular Risk Factors in Elderly Normolipidaemic Acute Myocardial Infarct Patients

“…Earlier studies in lipid profile analysis conducted on acute myocardial infarction patients (Mishra et al, 2001;Das et al, 2002;Goswami et al, 2003;Kharb et al, 2003;Malhotra et al, 2003;Burman et al, 2004;Rajashekhar et al, 2004;Sivaraman et al, 2004;Rani et al, 2005;Shindhe, et al, 2005;Yadhav et al, 2006;Patil et al, 2007) observed higher total cholesterol, triglyceride, low-density lipoprotein -cholesterol and lower levels of high-density lipoprotein-cholesterol in patients compared to controls.…”